{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:20:58Z","timestamp":1780942858116,"version":"3.54.1"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFA0502301"],"award-info":[{"award-number":["2016YFA0502301"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573350"],"award-info":[{"award-number":["81573350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872797"],"award-info":[{"award-number":["81872797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NSFC-Guangdong Joint Fund (the second phase)","award":["nsfc2015_447"],"award-info":[{"award-number":["nsfc2015_447"]}]},{"name":"National Science & Technology Major Project ?Key New Drug Creation and Manufacturing Program?, China","award":["2018ZX09711002"],"award-info":[{"award-number":["2018ZX09711002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2019,8,26]]},"DOI":"10.1021\/acs.jcim.9b00332","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T18:44:45Z","timestamp":1562093085000},"page":"3353-3358","source":"Crossref","is-referenced-by-count":76,"title":["D3Pockets: A Method and Web Server for Systematic Analysis of Protein Pocket Dynamics"],"prefix":"10.1021","volume":"59","author":[{"given":"Zhaoqiang","family":"Chen","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinben","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinan","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-8473","authenticated-orcid":true,"given":"Zhijian","family":"Xu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixian","family":"Chen","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"},{"name":"Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiye","family":"Shi","sequence":"additional","affiliation":[{"name":"UCB Biopharma SPRL, Chemin du Foriest, Braine-l\u2019 Alleud B-1420, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-5299","authenticated-orcid":true,"given":"Weiliang","family":"Zhu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"},{"name":"Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2011.12.005"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150825142002"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.2147\/AABC.S105289"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1059816"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500346"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161226202"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(92)80074-N"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/S1093-3263(98)00002-3"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1186\/1752-153X-1-7"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22608"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(95)00073-9"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008124202956"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21283"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp599"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq672"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560070905"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-168"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-197"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00572"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20897"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ci200613b"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ci200454v"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9426-6"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/ci5006004"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/ci500624s"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/ci800324m"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/ci200266d"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ci400219z"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-015-0059-5"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ci300184x"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2016.1146250"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00516"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.15.4995"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2007.09.017"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/2\/4\/S07"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.6b00101"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jm070095g"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu822"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr550"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/ci4000294"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.7b00500"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.7b00211"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.6b00039"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00014"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA09691G"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/med.1012"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112419"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00315"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01690"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.9b00332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T06:59:32Z","timestamp":1682492372000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.9b00332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8,26]]}},"alternative-id":["10.1021\/acs.jcim.9b00332"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.9b00332","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]}}}