{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:58:45Z","timestamp":1772780325666,"version":"3.50.1"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003807","name":"People's Government of Jilin Province","doi-asserted-by":"publisher","award":["20190103098JH"],"award-info":[{"award-number":["20190103098JH"]}],"id":[{"id":"10.13039\/501100003807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["2015219"],"award-info":[{"award-number":["2015219"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20180109KJ"],"award-info":[{"award-number":["JJKH20180109KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20180179KJ"],"award-info":[{"award-number":["JJKH20180179KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2019,10,28]]},"DOI":"10.1021\/acs.jcim.9b00642","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T18:05:38Z","timestamp":1570471538000},"page":"4402-4412","source":"Crossref","is-referenced-by-count":16,"title":["Molecular Mechanism of S1P Binding and Activation of the S1P<sub>1<\/sub> Receptor"],"prefix":"10.1021","volume":"59","author":[{"given":"Zhenyan","family":"Jiang","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-5468","authenticated-orcid":true,"given":"Hansi","family":"Zhang","sequence":"additional","affiliation":[]}],"member":"316","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2006.04.001"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2518"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.09.003"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.1.0390"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.02.006"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nature11896"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2174\/092986712799320556"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.05.002"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2014.12.002"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63380-4.00001-9"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.08.003"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5480.739"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1126\/science.1150577"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nature10361"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nature09789"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110499108"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ja404391q"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/nature10136"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1821"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003261"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00645.x"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3165"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02104-5"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.041590"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/srep22639"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2007.11.001"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1104614108"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-062411-130916"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-9471(05)80049-7"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007680200"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2007.03.004"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609648200"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215904"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.06.002"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2013.01.009"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.46.120604.141218"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003160"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/nature07330"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/nature09795"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000574"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2010.10.007"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901074106"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201409679"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5733"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/srep30655"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/ci200227u"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1042\/bj2830001"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.5.9141501"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.60.070191.003253"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-032112-135923"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00030-8"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01453"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.01.002"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.38.23631"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1042\/bj3320781"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.4.726"},{"key":"ref57\/cit57","first-page":"14","volume":"17","author":"Kent R. S.","year":"1980","journal-title":"Mol. Pharmacol."},{"key":"ref58\/cit58","unstructured":"DeLano, W. L. PyMOL Molecular Graphics System; Schr\u00f6dinger, LLC, 2002; http:\/\/www.pymol.org."},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/ct300646g"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00209"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000810"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1063\/1.448118"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/ct400617g"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/ct700301q"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22711"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/ct300342n"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1063\/1.447334"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.31.1695"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1063\/1.328693"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.9b00642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T06:21:41Z","timestamp":1681626101000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.9b00642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,7]]},"references-count":71,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10,28]]}},"alternative-id":["10.1021\/acs.jcim.9b00642"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.9b00642","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,7]]}}}