{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:33:40Z","timestamp":1771670020872,"version":"3.50.1"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Comput. Sci."],"published-print":{"date-parts":[[2002,3,1]]},"DOI":"10.1021\/ci010375j","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:50:07Z","timestamp":1027659007000},"page":"375-385","source":"Crossref","is-referenced-by-count":127,"title":["Combinatorial Library Design Using a Multiobjective Genetic Algorithm"],"prefix":"10.1021","volume":"42","author":[{"given":"Valerie J.","family":"Gillet","sequence":"first","affiliation":[{"name":"Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, Department of Automatic Control and Systems Engineering, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, and GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Khatib","sequence":"additional","affiliation":[{"name":"Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, Department of Automatic Control and Systems Engineering, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, and GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Willett","sequence":"additional","affiliation":[{"name":"Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, Department of Automatic Control and Systems Engineering, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, and GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, Department of Automatic Control and Systems Engineering, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, and GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren V. S.","family":"Green","sequence":"additional","affiliation":[{"name":"Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, Department of Automatic Control and Systems Engineering, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, and GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2002,1,31]]},"reference":[{"key":"ci010375jb00001\/ci010375jb00001_1","doi-asserted-by":"crossref","DOI":"10.1002\/9783527613083","volume-title":"Virtual Screening for Bioactive Molecules","author":"Bohm H.-J.","year":"2000"},{"key":"ci010375jb00002\/ci010375jb00002_1","volume-title":"Molecular Diversity in Drug Design","author":"Dean P. M.","year":"1999"},{"key":"ci010375jb00003\/ci010375jb00003_1","volume-title":"Computational Methods for the Analysis of Molecular Diversity. Perspect. Drug Discovery Des","author":"Willett P.","year":"1997"},{"key":"ci010375jb00004\/ci010375jb00004_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1021\/cc9800024","volume":"1","author":"Martin E. J.","year":"1999","journal-title":"J. Comb. Chem."},{"key":"ci010375jb00005\/ci010375jb00005_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1359-6446(00)01517-8","volume":"5","author":"Valler M. J.","year":"2000","journal-title":"Drug Discovery Today"},{"key":"ci010375jb00006\/ci010375jb00006_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski C. A.","year":"1997","journal-title":"Adv. Drug Delivery Rev."},{"key":"ci010375jb00007\/ci010375jb00007_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/ci980332b","volume":"39","author":"Gillet V. J.","year":"1999","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci010375jb00008\/ci010375jb00008_1","doi-asserted-by":"crossref","unstructured":"Zheng, W.; Hung, S. T.; Saunders:\u2009 J. T.; Seibel, G. L. PICCOLO:\u2009 A tool for combinatorial library design via multicriterion optimization. InPacificSymposium on Biocomputing2000; Atlman, R. B., Dunkar, A. K., Hunter, L., Lauderdale K., Klein, T. E., Eds.; World Scientific:\u2009 Singapore, 2000; pp 588\u2212599.","DOI":"10.1142\/9789814447331_0056"},{"key":"ci010375jb00009\/ci010375jb00009_1","first-page":"437","volume":"18","author":"Brown J. D.","year":"2000","journal-title":"J. Mol. Graph. Model."},{"key":"ci010375jb00010\/ci010375jb00010_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S1093-3263(00)00063-2","volume":"18","author":"Rassokhin D. N.","year":"2000","journal-title":"J. Mol. Graph. Model."},{"key":"ci010375jb00011\/ci010375jb00011_1","first-page":"1436","volume":"38","author":"Martin E. J.","year":"1995","journal-title":"J. Med. Chem."},{"key":"ci010375jb00012\/ci010375jb00012_1","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1021\/ci970420g","volume":"37","author":"Gillet V. J.","year":"1997","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci010375jb00013\/ci010375jb00013_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1023\/A:1008797526431","volume":"20","author":"Gillet V. J.","year":"2000","journal-title":"Perspect. Drug Discov. Des."},{"key":"ci010375jb00014\/ci010375jb00014_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1021\/ci990015k","volume":"40","author":"Jamois E. A.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci010375jb00015\/ci010375jb00015_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1021\/ci00024a021","volume":"35","author":"Sheridan R. P.","year":"1995","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci010375jb00016\/ci010375jb00016_1","first-page":"334","volume":"18","author":"Sheridan R. P.","year":"2000","journal-title":"J. Mol. Graph. Model."},{"key":"ci010375jb00017\/ci010375jb00017_1","first-page":"2313","volume":"40","author":"Brown R. D.","year":"1997","journal-title":"J. Med. Chem."},{"key":"ci010375jb00018\/ci010375jb00018_1","first-page":"851","volume":"37","author":"Agrafiotis D. K","year":"1997","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci010375jb00019\/ci010375jb00019_1","first-page":"3936","volume":"40","author":"Good A. C.","year":"1997","journal-title":"J. Med. Chem."},{"key":"ci010375jb00021\/ci010375jb00021_1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1006\/jmbi.1996.0897","volume":"267","author":"Jones G.","year":"1997","journal-title":"J. Mol. Biol."},{"key":"ci010375jb00022\/ci010375jb00022_1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1021\/ci000389+","volume":"40","author":"Bravi G.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci010375jb00023\/ci010375jb00023_1","volume-title":"Evolutionary Computation","volume":"3","author":"Fonseca C. M.","year":"1995"},{"key":"ci010375jb00024\/ci010375jb00024_1","first-page":"423","volume-title":"Genetic Algorithms:\u2009 Proceedings of the Fifth International Conference","author":"Fonseca C. M.","year":"1993"},{"key":"ci010375jb00025\/ci010375jb00025_1","first-page":"143","volume":"32","author":"Coello Coello C. A","year":"2000","journal-title":"ACM Comput. Surveys"},{"key":"ci010375jb00026\/ci010375jb00026_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/ci970438r","volume":"38","author":"Handschuh S.","year":"1998","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci010375jb00027\/ci010375jb00027_1","volume-title":"National Meeting of the American Chemical Society","author":"Gillet V. J."},{"key":"ci010375jb00031\/ci010375jb00031_1","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1021\/ci9904259","volume":"39","author":"Leach A. R.","year":"1999","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci010375jb00032\/ci010375jb00032_1","first-page":"114","volume":"7","author":"Mason J. S.","year":"1997","journal-title":"Perspect. Drug DiscoveryDes."},{"key":"ci010375jb00034\/ci010375jb00034_1","volume-title":"Designing focused libraries using MoSELECT. J. Mol. Graph. Model","author":"Gillet V. J."}],"container-title":["Journal of Chemical Information and Computer Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci010375j","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T01:39:47Z","timestamp":1633484387000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci010375j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,31]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,3,1]]}},"alternative-id":["10.1021\/ci010375j"],"URL":"https:\/\/doi.org\/10.1021\/ci010375j","relation":{},"ISSN":["0095-2338"],"issn-type":[{"value":"0095-2338","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1,31]]}}}