{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:05:38Z","timestamp":1774076738925,"version":"3.50.1"},"reference-count":24,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Comput. Sci."],"published-print":{"date-parts":[[2003,1,1]]},"DOI":"10.1021\/ci020378b","type":"journal-article","created":{"date-parts":[[2003,1,27]],"date-time":"2003-01-27T13:55:30Z","timestamp":1043675730000},"page":"120-125","source":"Crossref","is-referenced-by-count":89,"title":["On the Role of Polarizability in Chemical\u2212Biological Interactions"],"prefix":"10.1021","volume":"43","author":[{"given":"Corwin","family":"Hansch","sequence":"first","affiliation":[{"name":"Department of Chemistry, Pomona College, Claremont, California 91711, BioByte Corp., Claremont, California 91711, and David Hoekman Consulting, Seattle, Washington 98117"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne E.","family":"Steinmetz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Pomona College, Claremont, California 91711, BioByte Corp., Claremont, California 91711, and David Hoekman Consulting, Seattle, Washington 98117"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert J.","family":"Leo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Pomona College, Claremont, California 91711, BioByte Corp., Claremont, California 91711, and David Hoekman Consulting, Seattle, Washington 98117"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh B.","family":"Mekapati","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Pomona College, Claremont, California 91711, BioByte Corp., Claremont, California 91711, and David Hoekman Consulting, Seattle, Washington 98117"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alka","family":"Kurup","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Pomona College, Claremont, California 91711, BioByte Corp., Claremont, California 91711, and David Hoekman Consulting, Seattle, Washington 98117"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hoekman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Pomona College, Claremont, California 91711, BioByte Corp., Claremont, California 91711, and David Hoekman Consulting, Seattle, Washington 98117"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2002,12,13]]},"reference":[{"key":"ci020378bb00001\/ci020378bb00001_1","first-page":"2733","volume":"2729","author":"Selassie C. D.","year":"1999","journal-title":"Perkin Trans. 2"},{"key":"ci020378bb00002\/ci020378bb00002_1","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1021\/cr9601021","volume":"97","author":"Hansch C.","year":"1997","journal-title":"Chem. Rev."},{"key":"ci020378bb00003\/ci020378bb00003_1","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1021\/cr940024m","volume":"102","author":"Selassie C. D.","year":"2002","journal-title":"Chem. Rev."},{"key":"ci020378bb00004\/ci020378bb00004_1","volume-title":"On the Parametrization of the Toxicity of Organic Chemicals to Tetrahymena Pyriformis. The Problem of Establishing a Uniform Activity. J. Chem. Inf. Comput. Sci","author":"Mekapati S. B.","year":"2002"},{"key":"ci020378bb00005\/ci020378bb00005_1","unstructured":"Pauling, L.The Nature of the Chemical Bond; Cornell University Press:\u2009 3rd Edition, 1960; p 607."},{"key":"ci020378bb00006\/ci020378bb00006_1","unstructured":"Hansch, C.; Leo, A.Exploring QSAR. Fundamentals and Applications inChemistry and Biology; American Chemical Society, 1995; p 78."},{"key":"ci020378bb00007\/ci020378bb00007_1","first-page":"246","volume":"23","author":"Biobyte Corporation","year":"1987","journal-title":"Chromatographia"},{"key":"ci020378bb00008\/ci020378bb00008_1","first-page":"1855","volume":"1833","author":"Vogel A. I","year":"1948","journal-title":"J. Chem. Soc."},{"key":"ci020378bb00009\/ci020378bb00009_1","first-page":"575","volume":"570","author":"Jeffery G. H.","year":"1961","journal-title":"J. Chem. Soc."},{"key":"ci020378bb00010\/ci020378bb00010_1","first-page":"358","author":"Vogel W. T.","year":"1950","journal-title":"Chem. Ind."},{"key":"ci020378bb00011\/ci020378bb00011_1","unstructured":"Karplus, I. M.; Porter, R. H.Atoms and Molecules; W. A. Benjamin, Inc.\u2009 Menlo Park, CA, 1971; pp 250\u2212262."},{"key":"ci020378bb00012\/ci020378bb00012_1","unstructured":"Flygare, W. H.Molecular Structure and Dynamics; Prentice Hall Inc.\u2009 Englewood Cliffs, NJ, 1978; pp 402\u2212412."},{"key":"ci020378bb00013\/ci020378bb00013_1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1039\/TF9403600936","volume":"36","author":"Denbigh K. G","year":"1940","journal-title":"Trans. Faraday Soc."},{"key":"ci020378bb00014\/ci020378bb00014_1","first-page":"2689","volume":"2686","author":"Clementi E.","year":"1963","journal-title":"J. Chem. Phys."},{"key":"ci020378bb00015\/ci020378bb00015_1","volume-title":"National Institute of Standards and Technology","author":"Computational Chemistry Comparative"},{"key":"ci020378bb00016\/ci020378bb00016_1","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1021\/ja01222a034","volume":"67","author":"Pauling L.","year":"1945","journal-title":"J. Am. Chem. Soc."},{"key":"ci020378bb00017\/ci020378bb00017_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0003-9861(69)90523-2","volume":"135","author":"Kutter E.","year":"1969","journal-title":"Arch. Biochem. Biophys."},{"key":"ci020378bb00018\/ci020378bb00018_1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1073\/pnas.53.5.952","volume":"53","author":"Agin D.","year":"1965","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ci020378bb00019\/ci020378bb00019_1","volume-title":"Electronic and Steric Constants","author":"Hansch C.","year":"1995"},{"key":"ci020378bb00020\/ci020378bb00020_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/qsar.19880070204","volume":"7","author":"Kamlet J.","year":"1988","journal-title":"Quant. Struct.-Act. Relat."},{"key":"ci020378bb00021\/ci020378bb00021_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s002320010065","volume":"180","author":"Hahin R.","year":"2001","journal-title":"J. Membrane Biol."},{"key":"ci020378bb00022\/ci020378bb00022_1","first-page":"314","volume":"8","author":"Wien R.","year":"1953","journal-title":"Brit. J. Pharmacol."},{"key":"ci020378bb00023\/ci020378bb00023_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0048-3575(87)90024-1","volume":"28","author":"Nishimura K.","year":"1987","journal-title":"Pest. Biochem. Physiol"},{"key":"ci020378bb00024\/ci020378bb00024_1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1021\/cr0102009","volume":"102","author":"Hansch C.","year":"2002","journal-title":"Chem. Rev."}],"container-title":["Journal of Chemical Information and Computer Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci020378b","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T02:21:57Z","timestamp":1680834117000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci020378b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,13]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1,1]]}},"alternative-id":["10.1021\/ci020378b"],"URL":"https:\/\/doi.org\/10.1021\/ci020378b","relation":{},"ISSN":["0095-2338","1520-5142"],"issn-type":[{"value":"0095-2338","type":"print"},{"value":"1520-5142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,13]]}}}