{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:51:28Z","timestamp":1780584688866,"version":"3.54.1"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Comput. Sci."],"published-print":{"date-parts":[[2003,3,1]]},"DOI":"10.1021\/ci0255836","type":"journal-article","created":{"date-parts":[[2003,3,24]],"date-time":"2003-03-24T14:54:26Z","timestamp":1048517666000},"page":"381-390","source":"Crossref","is-referenced-by-count":36,"title":["Optimizing the Size and Configuration of Combinatorial Libraries"],"prefix":"10.1021","volume":"43","author":[{"given":"Trudi","family":"Wright","sequence":"first","affiliation":[{"name":"Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, and GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie J.","family":"Gillet","sequence":"additional","affiliation":[{"name":"Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, and GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren V. S.","family":"Green","sequence":"additional","affiliation":[{"name":"Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, and GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Pickett","sequence":"additional","affiliation":[{"name":"Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom, and GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2002,12,21]]},"reference":[{"key":"ci0255836b00001\/ci0255836b00001_1","volume-title":"Software Tools and Applications in Drug Discovery","author":"Combinatorial Library Design","year":"2001"},{"key":"ci0255836b00002\/ci0255836b00002_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1359-6446(00)01517-8","volume":"5","author":"Valler M. J.","year":"2000","journal-title":"Drug Discovery Today"},{"key":"ci0255836b00003\/ci0255836b00003_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski C. A.","year":"1997","journal-title":"Adv. Drug Delivery Rev."},{"key":"ci0255836b00004\/ci0255836b00004_1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1021\/ci010366a","volume":"41","author":"Oprea T. I.","year":"2001","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci0255836b00005\/ci0255836b00005_1","first-page":"864","volume":"41","author":"Hann M. M.","year":"2001","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci0255836b00006\/ci0255836b00006_1","first-page":"3936","volume":"40","author":"Good A. C.","year":"1997","journal-title":"J. Med. Chem."},{"key":"ci0255836b00007\/ci0255836b00007_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1021\/cc9800024","volume":"1","author":"Martin E. J.","year":"1999","journal-title":"J. Comb. Chem."},{"key":"ci0255836b00008\/ci0255836b00008_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/ci980332b","volume":"39","author":"Gillet V. J.","year":"1999","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci0255836b00009\/ci0255836b00009_1","doi-asserted-by":"crossref","unstructured":"Zheng, W.; Hung, S. T.; Saunders, J. T.; Seibel, G. L. PICCOLO:\u2009 A Tool for Combinatorial Library Design via Multicriterion Optimization. InPacific Symposium on Biocomputing2000; Atlman, R. B., Dunkar, A. K., Hunter, L., Lauderdale K., Klein, T. E., Eds.; World Scientific:\u2009 Singapore, 2000; pp 588\u2212599.","DOI":"10.1142\/9789814447331_0056"},{"key":"ci0255836b00010\/ci0255836b00010_1","first-page":"437","volume":"18","author":"Brown J. D.","year":"2000","journal-title":"J. Mol Graph. Model."},{"key":"ci0255836b00011\/ci0255836b00011_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1021\/ci010375j","volume":"42","author":"Gillet V. J.","year":"2002","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci0255836b00012\/ci0255836b00012_1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S1093-3263(01)00150-4","volume":"20","author":"Gillet V. J.","year":"2002","journal-title":"J. Mol Graph. Model."},{"key":"ci0255836b00014\/ci0255836b00014_1","first-page":"566","volume":"45","author":"Agrafiotis D. K","year":"2001","journal-title":"IBM R. Res., Dev."},{"key":"ci0255836b00015\/ci0255836b00015_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1162\/evco.1995.3.1.1","volume":"3","author":"Fonseca C. M.","year":"1995","journal-title":"Evolutionary Comput."},{"key":"ci0255836b00016\/ci0255836b00016_1","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1021\/jm020919o","volume":"45","author":"Nicolotti O.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ci0255836b00017\/ci0255836b00017_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/ci970438r","volume":"38","author":"Handschuh S.","year":"1998","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci0255836b00018\/ci0255836b00018_1","volume-title":"Genetic Algorithms in Search, Optimization and Machine Learning","author":"Goldberg D. E.","year":"1989"},{"key":"ci0255836b00019\/ci0255836b00019_1","first-page":"2313","volume":"40","author":"Brown R. D.","year":"1997","journal-title":"J. Med. Chem."},{"key":"ci0255836b00020\/ci0255836b00020_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1021\/ci990261w","volume":"40","author":"Pickett S. D.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci0255836b00021\/ci0255836b00021_1","first-page":"37","volume":"28","author":"Fonseca C. M.","year":"1998","journal-title":"IEEE Trans. Systems, Man, Cybernetics"},{"key":"ci0255836b00024\/ci0255836b00024_1","first-page":"593","volume-title":"Parallel Problem Solving From Nature V","author":"Fonseca C. M.","year":"1995"},{"key":"ci0255836b00025\/ci0255836b00025_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-5184-0","volume-title":"Evolutionary Algorithms for Solving Multi-Objective Problems","author":"Coello Coello C. A.","year":"2002"}],"container-title":["Journal of Chemical Information and Computer Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci0255836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T01:47:51Z","timestamp":1678844871000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci0255836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,21]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,3,1]]}},"alternative-id":["10.1021\/ci0255836"],"URL":"https:\/\/doi.org\/10.1021\/ci0255836","relation":{},"ISSN":["0095-2338","1520-5142"],"issn-type":[{"value":"0095-2338","type":"print"},{"value":"1520-5142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,21]]}}}