{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:08:24Z","timestamp":1791328104761,"version":"4.3.1"},"reference-count":27,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Comput. Sci."],"published-print":{"date-parts":[[2003,7,1]]},"DOI":"10.1021\/ci034043l","type":"journal-article","created":{"date-parts":[[2003,7,21]],"date-time":"2003-07-21T13:04:04Z","timestamp":1058792644000},"page":"1269-1275","source":"Crossref","is-referenced-by-count":85,"title":["Development of a Method for Evaluating Drug-Likeness and Ease of Synthesis Using a Data Set in Which Compounds Are Assigned Scores Based on Chemists' Intuition"],"prefix":"10.1021","volume":"43","author":[{"given":"Yuji","family":"Takaoka","sequence":"first","affiliation":[{"name":"Molecular Simulation Group, Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, 331-9530 Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Endo","sequence":"additional","affiliation":[{"name":"Molecular Simulation Group, Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, 331-9530 Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Yamanobe","sequence":"additional","affiliation":[{"name":"Molecular Simulation Group, Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, 331-9530 Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kakinuma","sequence":"additional","affiliation":[{"name":"Molecular Simulation Group, Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, 331-9530 Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketoshi","family":"Okubo","sequence":"additional","affiliation":[{"name":"Molecular Simulation Group, Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, 331-9530 Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichi","family":"Shimazaki","sequence":"additional","affiliation":[{"name":"Molecular Simulation Group, Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, 331-9530 Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Ota","sequence":"additional","affiliation":[{"name":"Molecular Simulation Group, Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, 331-9530 Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Sumiya","sequence":"additional","affiliation":[{"name":"Molecular Simulation Group, Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, 331-9530 Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensei","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Molecular Simulation Group, Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, 331-9530 Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2003,5,21]]},"reference":[{"key":"ci034043lb00001\/ci034043lb00001_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski C. A.","year":"1997","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"ci034043lb00002\/ci034043lb00002_1","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1016\/S1359-6446(02)02288-2","volume":"7","author":"Butina D.","year":"2002","journal-title":"Drug Discovery Today"},{"key":"ci034043lb00003\/ci034043lb00003_1","first-page":"890","volume":"40","author":"Basak S. C.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci034043lb00004\/ci034043lb00004_1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1021\/ci990039r","volume":"39","author":"Wang J.","year":"1999","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci034043lb00005\/ci034043lb00005_1","volume-title":"This workshop was organized jointly with the European Chemicals Bureau (ECB), Joint Research Centre","author":"Dearden J. C.","year":"1999"},{"key":"ci034043lb00006\/ci034043lb00006_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2174\/1568026013395074","volume":"1","author":"Pearl G. M.","year":"2001","journal-title":"Curr. Top. Med. Chem."},{"key":"ci034043lb00007\/ci034043lb00007_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1021\/ci990268d","volume":"40","author":"Darvas F.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci034043lb00008\/ci034043lb00008_1","first-page":"3877","volume":"43","author":"Egan W. J.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ci034043lb00009\/ci034043lb00009_1","first-page":"116","volume":"7","author":"Beresford A. P.","year":"2002","journal-title":"Drug Discovery Today"},{"key":"ci034043lb00010\/ci034043lb00010_1","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1021\/jm970666c","volume":"41","author":"Ajay","year":"1998","journal-title":"J. Med. Chem."},{"key":"ci034043lb00011\/ci034043lb00011_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S1359-6446(99)01451-8","volume":"5","author":"Clark D. E.","year":"2000","journal-title":"Drug Discovery Today"},{"key":"ci034043lb00012\/ci034043lb00012_1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1021\/ci0003810","volume":"40","author":"Frimurer M.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci034043lb00013\/ci034043lb00013_1","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1021\/jm015507e","volume":"44","author":"Muegge I.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ci034043lb00014\/ci034043lb00014_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0169-409X(02)00003-0","volume":"54","author":"Walters W. P.","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ci034043lb00015\/ci034043lb00015_1","first-page":"1187","volume":"40","author":"Xu J.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci034043lb00016\/ci034043lb00016_1","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1021\/jm9706776","volume":"41","author":"Sadowski J.","year":"1998","journal-title":"J. Med. Chem."},{"key":"ci034043lb00017\/ci034043lb00017_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1021\/ci990266t","volume":"40","author":"Wagener M.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci034043lb00022\/ci034043lb00022_1","volume-title":"MOE 2002","year":"2002"},{"key":"ci034043lb00023\/ci034043lb00023_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1021\/ci990307l","volume":"39","author":"Wildman S. A.","year":"1999","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci034043lb00025\/ci034043lb00025_1","first-page":"1228","volume":"39","author":"Aoyama T.","year":"1991","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"ci034043lb00026\/ci034043lb00026_1","first-page":"293","volume":"36","author":"Isu Y.","year":"1996","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci034043lb00027\/ci034043lb00027_1","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511801389","volume-title":"An Introduction to Support Vector Machines and Other Kernel-Based Learning Methods","author":"Cristianini N.","year":"2000"},{"key":"ci034043lb00028\/ci034043lb00028_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/1521-3838(200110)20:3<227::AID-QSAR227>3.0.CO;2-Y","volume":"20","author":"Czermi\u0144ski R.","year":"2001","journal-title":"Quant. Struct.-Act. Relat."},{"key":"ci034043lb00029\/ci034043lb00029_1","first-page":"114","volume":"521","author":"Bao L.","year":"2002","journal-title":"FEBS Lett."},{"key":"ci034043lb00030\/ci034043lb00030_1","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/prot.10176","volume":"48","author":"Yuan Z.","year":"2002","journal-title":"Proteins"},{"key":"ci034043lb00031\/ci034043lb00031_1","first-page":"2147","volume":"13","author":"Chang C.-C.","year":"2001","journal-title":"Neural Comput."},{"key":"ci034043lb00032\/ci034043lb00032_1","unstructured":"Chang, C.C.; Lin, C.J. LIBSVM 2.0:\u2009 Solving different support vector formulations2000,http:\/\/www.csie.ntu.edu.tw\/\u223ccjlin\/libsvm."}],"container-title":["Journal of Chemical Information and Computer Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci034043l","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T13:35:45Z","timestamp":1632231345000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci034043l"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5,21]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,7,1]]}},"alternative-id":["10.1021\/ci034043l"],"URL":"https:\/\/doi.org\/10.1021\/ci034043l","relation":{},"ISSN":["0095-2338"],"issn-type":[{"value":"0095-2338","type":"print"}],"subject":[],"published":{"date-parts":[[2003,5,21]]}}}