{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:50:43Z","timestamp":1761292243860},"reference-count":31,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2005,3,1]]},"DOI":"10.1021\/ci049692r","type":"journal-article","created":{"date-parts":[[2005,3,28]],"date-time":"2005-03-28T05:31:21Z","timestamp":1111987881000},"page":"314-320","source":"Crossref","is-referenced-by-count":9,"title":["Combinatorial Ligand Design Targeted at Protein Families"],"prefix":"10.1021","volume":"45","author":[{"given":"Nikolay P.","family":"Todorov","sequence":"first","affiliation":[{"name":"De Novo Pharmaceuticals Ltd., Vision Park, Histon, Cambridge CB4 9ZR, U.K., and Novartis Forschungsinstitut GmbH, GDC, Brunner Strasse 59, A-1235 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph L.","family":"Buenemann","sequence":"additional","affiliation":[{"name":"De Novo Pharmaceuticals Ltd., Vision Park, Histon, Cambridge CB4 9ZR, U.K., and Novartis Forschungsinstitut GmbH, GDC, Brunner Strasse 59, A-1235 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian L.","family":"Alberts","sequence":"additional","affiliation":[{"name":"De Novo Pharmaceuticals Ltd., Vision Park, Histon, Cambridge CB4 9ZR, U.K., and Novartis Forschungsinstitut GmbH, GDC, Brunner Strasse 59, A-1235 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2005,3,8]]},"reference":[{"key":"ci049692rb00001\/ci049692rb00001_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0006-2952(02)01479-X","volume":"65","author":"Gadek T. R.","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ci049692rb00002\/ci049692rb00002_1","first-page":"413","volume":"5","author":"Waszkowycz B","year":"2002","journal-title":"Curr. Opin. Drug Discovery Dev."},{"key":"ci049692rb00003\/ci049692rb00003_1","first-page":"1055","volume":"7","author":"Lyne P. D","year":"2002","journal-title":"Drug Discovery Today"},{"key":"ci049692rb00004\/ci049692rb00004_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1146\/annurev.pharmtox.37.1.71","volume":"37","author":"Marrone T. J.","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ci049692rb00005\/ci049692rb00005_1","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1021\/jm001044l","volume":"43","author":"Bissantz C.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ci049692rb00006\/ci049692rb00006_1","first-page":"318","volume":"42","author":"Lamb M. L.","year":"2001","journal-title":"Proteins"},{"key":"ci049692rb00007\/ci049692rb00007_1","first-page":"445","volume":"25","author":"Janin J","year":"1996","journal-title":"Proteins"},{"key":"ci049692rb00008\/ci049692rb00008_1","first-page":"3325","volume":"46","author":"Sims P. A.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ci049692rb00009\/ci049692rb00009_1","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1021\/jm000934y","volume":"43","author":"Kastenholz M. A.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ci049692rb00010\/ci049692rb00010_1","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1021\/jm0109107","volume":"44","author":"Ridderstrom M.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ci049692rb00011\/ci049692rb00011_1","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1021\/jm030833a","volume":"46","author":"Baskin I. I.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ci049692rb00012\/ci049692rb00012_1","doi-asserted-by":"crossref","first-page":"9131","DOI":"10.1063\/1.481522","volume":"112","author":"Kangas E.","year":"2000","journal-title":"J. Chem. Phys."},{"key":"ci049692rb00013\/ci049692rb00013_1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S1074-5521(02)00238-7","volume":"9","author":"Greenbaum D. C.","year":"2002","journal-title":"Chem., Biol."},{"key":"ci049692rb00014\/ci049692rb00014_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1021\/jm030161o","volume":"47","author":"Vigers G. P.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ci049692rb00015\/ci049692rb00015_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0165-6147(02)02071-0","volume":"23","author":"Knockaert M.","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"ci049692rb00016\/ci049692rb00016_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/374131a0","volume":"374","author":"Morgan D. O","year":"1995","journal-title":"Nature"},{"key":"ci049692rb00017\/ci049692rb00017_1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1006\/jmbi.1999.2640","volume":"287","author":"Pavletich N. P","year":"1999","journal-title":"J. Mol. Biol."},{"key":"ci049692rb00018\/ci049692rb00018_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/prot.340140216","volume":"14","author":"Russell R. B.","year":"1992","journal-title":"Proteins"},{"key":"ci049692rb00019\/ci049692rb00019_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1023\/A:1008042711516","volume":"11","author":"Todorov N. P.","year":"1997","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ci049692rb00020\/ci049692rb00020_1","volume-title":"Biological Phisics","author":"Todorov N. P.","year":"1999"},{"key":"ci049692rb00021\/ci049692rb00021_1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1023\/A:1021242018286","volume":"16","author":"Stahl M.","year":"2002","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ci049692rb00022\/ci049692rb00022_1","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1021\/jm0003992","volume":"44","author":"Stahl M.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ci049692rb00023\/ci049692rb00023_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1021\/ci970429i","volume":"38","author":"Lewell X. Q.","year":"1998","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci049692rb00024\/ci049692rb00024_1","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1073\/pnas.96.18.9997","volume":"96","author":"Kuntz I. D.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ci049692rb00025\/ci049692rb00025_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1021\/jm990401t","volume":"43","author":"Shewchuk L.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ci049692rb00026\/ci049692rb00026_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/376313a0","volume":"376","author":"Jeffrey P. D.","year":"1995","journal-title":"Nature"},{"key":"ci049692rb00027\/ci049692rb00027_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/prot.340220408","volume":"22","author":"Schulze-Gahmen U.","year":"1995","journal-title":"Proteins"},{"key":"ci049692rb00028\/ci049692rb00028_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1097-2765(01)00343-4","volume":"8","author":"Tarricone C.","year":"2001","journal-title":"Mol. Cell"},{"key":"ci049692rb00029\/ci049692rb00029_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/26164","volume":"395","author":"Brotherton D. H.","year":"1998","journal-title":"Nature"},{"key":"ci049692rb00030\/ci049692rb00030_1","first-page":"181","volume":"9","author":"Schulze-Gahmen U.","year":"2002","journal-title":"Nature Struct. Biol."},{"key":"ci049692rb00033\/ci049692rb00033_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"Humphrey W.","year":"1996","journal-title":"J. Mol. Graph."}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci049692r","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T02:28:39Z","timestamp":1680834519000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci049692r"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,1]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3,1]]}},"alternative-id":["10.1021\/ci049692r"],"URL":"https:\/\/doi.org\/10.1021\/ci049692r","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,1]]}}}