{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:33:22Z","timestamp":1760297602889},"reference-count":17,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2006,3,1]]},"DOI":"10.1021\/ci050370c","type":"journal-article","created":{"date-parts":[[2006,3,27]],"date-time":"2006-03-27T05:39:14Z","timestamp":1143437954000},"page":"553-562","source":"Crossref","is-referenced-by-count":38,"title":["Mining a Chemical Database for Fragment Co-occurrence:\u2009 Discovery of \u201cChemical Clich\u00e9s\u201d"],"prefix":"10.1021","volume":"46","author":[{"given":"Eric-Wubbo","family":"Lameijer","sequence":"first","affiliation":[{"name":"Division of Medicinal Chemistry, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands, Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands, and NuTech Solutions, Martin-Schmeisser-Weg 15, 44227 Dortmund, Germany"}]},{"given":"Joost N.","family":"Kok","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands, Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands, and NuTech Solutions, Martin-Schmeisser-Weg 15, 44227 Dortmund, Germany"}]},{"given":"Thomas","family":"B\u00e4ck","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands, Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands, and NuTech Solutions, Martin-Schmeisser-Weg 15, 44227 Dortmund, Germany"}]},{"given":"Ad P.","family":"IJzerman","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands, Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands, and NuTech Solutions, Martin-Schmeisser-Weg 15, 44227 Dortmund, Germany"}]}],"member":"316","published-online":{"date-parts":[[2006,1,27]]},"reference":[{"key":"ci050370cb00003\/ci050370cb00003_1","first-page":"25","volume":"23","author":"Lipinksi C.","year":"1997","journal-title":"Adv. Drug Delivery Rev."},{"key":"ci050370cb00004\/ci050370cb00004_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1023\/A:1008130001697","volume":"14","author":"Oprea T","year":"2000","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ci050370cb00005\/ci050370cb00005_1","first-page":"1187","volume":"40","author":"Xu J.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci050370cb00006\/ci050370cb00006_1","first-page":"184","volume":"11","author":"Klopman G.","year":"1992","journal-title":"QSAR"},{"key":"ci050370cb00007\/ci050370cb00007_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1021\/jm040835a","volume":"48","author":"Kazius J.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ci050370cb00008\/ci050370cb00008_1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1021\/ci0255782","volume":"43","author":"Ertl P","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci050370cb00009\/ci050370cb00009_1","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1021\/jm0300429","volume":"46","author":"Lewell X.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ci050370cb00011\/ci050370cb00011_1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1021\/jm9602928","volume":"39","author":"Bemis G.","year":"1996","journal-title":"J. Med. Chem."},{"key":"ci050370cb00012\/ci050370cb00012_1","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1021\/jm9903996","volume":"42","author":"Bemis G.","year":"1999","journal-title":"J. Med. Chem."},{"key":"ci050370cb00013\/ci050370cb00013_1","first-page":"102","volume":"5","author":"Xue L.","year":"1999","journal-title":"J. Mol. Model."},{"key":"ci050370cb00014\/ci050370cb00014_1","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1021\/jm030809x","volume":"46","author":"Vinkers M.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ci050370cb00015\/ci050370cb00015_1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1023\/A:1008184403558","volume":"14","author":"Schneider G.","year":"2000","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ci050370cb00016\/ci050370cb00016_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1021\/ci970429i","volume":"38","author":"Lewell X.","year":"1998","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci050370cb00017\/ci050370cb00017_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1021\/ci00062a008","volume":"29","author":"Weininger D.","year":"1989","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci050370cb00018\/ci050370cb00018_1","unstructured":"CMC is currently 2005 marketed by Elsevier MDL, see also the Web sitehttp:\/\/www.mdl.com\/products\/knowledge\/medicinal_chem\/index.jsp."},{"key":"ci050370cb00020\/ci050370cb00020_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1021\/ci990086j","volume":"40","author":"Wild D.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci050370cb00021\/ci050370cb00021_1","first-page":"182","volume":"45","author":"Irwin J.","year":"2005","journal-title":"J. Chem. Inf. Model."}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci050370c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T13:03:46Z","timestamp":1632229426000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci050370c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,27]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3,1]]}},"alternative-id":["10.1021\/ci050370c"],"URL":"https:\/\/doi.org\/10.1021\/ci050370c","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,27]]}}}