{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:54:56Z","timestamp":1772132096683,"version":"3.50.1"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2010,12,27]]},"DOI":"10.1021\/ci100203e","type":"journal-article","created":{"date-parts":[[2010,11,12]],"date-time":"2010-11-12T14:03:26Z","timestamp":1289570606000},"page":"2067-2078","source":"Crossref","is-referenced-by-count":45,"title":["Compound Set Enrichment: A Novel Approach to Analysis of Primary HTS Data"],"prefix":"10.1021","volume":"50","author":[{"given":"Thibault","family":"Varin","sequence":"first","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland, and 250 Massachusetts Avenue, Cambridge, Massachusetts 02139"}]},{"given":"Hanspeter","family":"Gubler","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland, and 250 Massachusetts Avenue, Cambridge, Massachusetts 02139"}]},{"given":"Christian N.","family":"Parker","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland, and 250 Massachusetts Avenue, Cambridge, Massachusetts 02139"}]},{"given":"Ji-Hu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland, and 250 Massachusetts Avenue, Cambridge, Massachusetts 02139"}]},{"given":"Pichai","family":"Raman","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland, and 250 Massachusetts Avenue, Cambridge, Massachusetts 02139"}]},{"given":"Peter","family":"Ertl","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland, and 250 Massachusetts Avenue, Cambridge, Massachusetts 02139"}]},{"given":"Ansgar","family":"Schuffenhauer","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland, and 250 Massachusetts Avenue, Cambridge, Massachusetts 02139"}]}],"member":"316","published-online":{"date-parts":[[2010,11,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.drudis.2006.02.001","volume":"11","author":"Macarron R.","year":"2006","journal-title":"Drug Discovery Today"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1177\/1087057108319644","volume":"13","author":"Mayr L. M.","year":"2008","journal-title":"J. Biomol. Screening"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nchembio.2007.17","volume":"3","author":"Inglese J.","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","volume":"4","author":"Zhang J. H.","year":"1999","journal-title":"J. Biomol. Screening"},{"key":"ref5\/cit5","first-page":"151","volume-title":"High-Throughput Screening in Drug Discovery","author":"Gubler H.","year":"2007","edition":"1"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ab.2006.11.036","volume":"361","author":"Buxser S.","year":"2007","journal-title":"Anal. Biochem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S1359-6446(97)01083-0","volume":"2","author":"Rishton G. M.","year":"1997","journal-title":"Drug Discovery Today"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.tibtech.2005.05.011","volume":"23","author":"Curtis R. K.","year":"2005","journal-title":"Trends Biotechnol."},{"key":"ref9\/cit9","first-page":"1","volume":"18","author":"Downs G. M.","year":"2002","journal-title":"Rev. Comput. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1021\/ci010244i","volume":"42","author":"Nicolaou C. A.","year":"2002","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1021\/ci0502808","volume":"45","author":"Yan S. F.","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1021\/jm9602928","volume":"39","author":"Bemis G. W.","year":"1996","journal-title":"J. Med. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1021\/ci025535l","volume":"42","author":"Xu Y. J.","year":"2002","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1021\/ci030025s","volume":"44","author":"Schreyer S. K.","year":"2004","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1021\/ci7003412","volume":"48","author":"Pollock S. N.","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1021\/ci0000631","volume":"40","author":"Roberts G.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1021\/jm0302703","volume":"46","author":"Cross K. P.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1021\/ci600338x","volume":"47","author":"Schuffenhauer A.","year":"2007","journal-title":"J. Chem. Inf. Model."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1021\/jm060217p","volume":"49","author":"Ertl P.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nrd1200","volume":"2","author":"Webber P. M.","year":"2003","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1021\/jm0303195","volume":"47","author":"Xia X.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref22\/cit22","unstructured":"Kirkman, T. W.Statistics to Use, 1996; http:\/\/www.physics.csbsju.edu\/stats\/KS-test.html(accessed Aug 13, 2008)."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1214\/aoms\/1177729550","volume":"22","author":"Birnbaum Z. W.","year":"1951","journal-title":"Ann. Math. Stat."},{"key":"ref24\/cit24","first-page":"6","volume-title":"Nonparametric Statistics for the Behavioral Sciences","author":"Siegel S.","year":"1988","edition":"2"},{"key":"ref25\/cit25","first-page":"103","volume-title":"Encyclopedia of Measurement and Statistics","author":"Abdi H.","year":"2007","edition":"1"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/01621459.1967.10482916","volume":"62","author":"Lilliefors H.","year":"1967","journal-title":"J. Am. Stat. Assoc."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nbt1186","volume":"24","author":"Malo N.","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1021\/jm0707727","volume":"51","author":"Boehm M.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1021\/ci800272a","volume":"49","author":"Lessel U.","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2174\/1386207043328238","volume":"7","author":"Schuffenhauer A.","year":"2004","journal-title":"Comb. Chem. High Throughput Screening"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1021\/jm034078c","volume":"46","author":"Mestres J.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nchembio.188","volume":"5","author":"Renner S.","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nchembio.187","volume":"5","author":"Wetzel S.","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10822-008-9206-7","volume":"22","author":"Cho S. J.","year":"2008","journal-title":"J. Comput.-Aided. Mol. Des."}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci100203e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T03:04:17Z","timestamp":1680663857000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci100203e"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12,27]]}},"alternative-id":["10.1021\/ci100203e"],"URL":"https:\/\/doi.org\/10.1021\/ci100203e","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13328984.14692096","asserted-by":"object"}]},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,12]]}}}