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Proceedings of the99th Annual Meeting of the American Urological Association,San Francisco, CA,May 08\u201313, 2004; p110."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1084\/jem.20042020","volume":"201","author":"Fox C. J.","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1074\/jbc.M707773200","volume":"283","author":"Xie Y.","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"20635","DOI":"10.1074\/jbc.M709479200","volume":"283","author":"Zemskova M.","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1021\/ol0620646","volume":"8","author":"Bregman H.","year":"2006","journal-title":"Org. Lett."},{"key":"ref15\/cit15","unstructured":"Bearss, D.; Liu, X.; Vankayalapati, H.; Xu, Y.Imidazo [1, 2-beta] pyridazine and pyrazolo [1,5-\u03b1] pyrimidine derivatives and their use as protein kinase inhibitors. U.S. Patent 2008\/0261988 A1, 2008."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"6916","DOI":"10.1158\/0008-5472.CAN-07-0320","volume":"67","author":"Pogacic V.","year":"2007","journal-title":"Cancer Res."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1021\/jm701248t","volume":"51","author":"Pierce A.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1016\/j.bmcl.2009.04.061","volume":"19","author":"Grey R.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1021\/jm901018f","volume":"52","author":"Aku\u00e9-G\u00e9du R.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.1021\/jm900943h","volume":"52","author":"Tao Z.-F.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1016\/j.bmcl.2010.03.061","volume":"20","author":"Sliman F.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nrd1549","volume":"3","author":"Kitchen D. B.","year":"2004","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1021\/jm900817u","volume":"53","author":"Leach A. R.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1021\/ci049641u","volume":"45","author":"Jorissen R. N.","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1021\/ci800387z","volume":"49","author":"Liew C.","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1021\/ci900135u","volume":"49","author":"Liu X.","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.drudis.2010.03.013","volume":"15","author":"Yang S.-Y.","year":"2010","journal-title":"Drug Discovery Today"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.bmcl.2006.12.086","volume":"17","author":"Cheney I. W.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1158\/1535-7163.MCT-06-0397","volume":"6","author":"Holder S.","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"ref30\/cit30","unstructured":"Kearney, P.; Brown, S.; Koltun, E.Aminopyrimidine, Aminopyridine and Aniline Derivatives Inhibitors of Pim-1 and\/or Pim-3. WO Patent WO\/2007\/044,724, 2007."},{"key":"ref31\/cit31","unstructured":"Burger, M.; Lindvall, M.; Han, W.; Lan, J.; Nishiguchi, G.; Shafer, C.; Bellamacina, C.; Huh, K.; Atallah, G.; Mcbride, C.; Pim kinase inhibitors and methods of their use. In WO Patent WO\/2008\/106,692: 2008."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1016\/j.bmcl.2008.08.079","volume":"18","author":"Tong Y.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.bmcl.2009.01.005","volume":"19","author":"Olla S.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/jm800937p","volume":"52","author":"Xia Z. P.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.artmed.2008.07.001","volume":"46","author":"Yang S. Y.","year":"2009","journal-title":"Artif. Intell. Med."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"7604","DOI":"10.1021\/jm0504858","volume":"48","author":"Bullock A. N.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref37\/cit37","unstructured":"Redkar, S.; Liu, X. H.; Gourley, E.; Lamb, J.; Grand, G.; Lloyd, M.; Wolfe, B.; Bearss, D.; Vankayalapati, H.InDiscovery of SGI-1776, a potent and selective PIM-1 kinase inhibitor. Proceedings of the100th Annual Meeting of the American Association for Cancer Research,San Diego, CA,April 18\u201322, 2009; Abstract no. 2013."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","volume":"267","author":"Jones G.","year":"1997","journal-title":"J. Mol. Biol."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/jcc.21498","volume":"31","author":"Li X.","year":"2010","journal-title":"J. Comput. Chem."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1021\/jm801242y","volume":"52","author":"Qian K.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/ci034289q","volume":"44","author":"Verdonk M. L.","year":"2004","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1021\/ci100050t","volume":"50","author":"Rogers D.","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"ref43\/cit43","first-page":"67","volume":"2","author":"Byvatov E.","year":"2003","journal-title":"Appl. Bioinformatics"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/bib\/5.4.328","volume":"5","author":"Yang Z. R.","year":"2004","journal-title":"Briefings Bioinf."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11030-009-9108-1","volume":"13","author":"Zhang H.","year":"2009","journal-title":"Mol. Diversity"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.jmgm.2007.12.002","volume":"26","author":"Han L. Y.","year":"2008","journal-title":"J. Mol. 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