{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:06:23Z","timestamp":1773414383076,"version":"3.50.1"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2012,4,23]]},"DOI":"10.1021\/ci200607f","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T18:04:48Z","timestamp":1331661888000},"page":"901-912","source":"Crossref","is-referenced-by-count":48,"title":["Dissecting Kinase Profiling Data to Predict Activity and Understand Cross-Reactivity of Kinase Inhibitors"],"prefix":"10.1021","volume":"52","author":[{"given":"Satoshi","family":"Niijima","sequence":"first","affiliation":[{"name":"Department\rof Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical\rSciences, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department\rof Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical\rSciences, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department\rof Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical\rSciences, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2012,3,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","volume":"298","author":"Manning G.","year":"2002","journal-title":"Science"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbapap.2003.11.028","volume":"1697","author":"Vieth M.","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S1359-6446(05)03477-X","volume":"10","author":"Vieth M.","year":"2005","journal-title":"Drug Discovery Today"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc2559","volume":"9","author":"Zhang J.","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nchembio.297","volume":"6","author":"Fedorov O.","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nrc2787","volume":"10","author":"Knight Z. A.","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nchembio.530","volume":"7","author":"Metz J. T.","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2174\/138955708786141043","volume":"8","author":"Sawa M.","year":"2008","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nbt1068","volume":"23","author":"Fabian M. A.","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1073\/pnas.0511292103","volume":"103","author":"Melnick J. S.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"20523","DOI":"10.1073\/pnas.0708800104","volume":"104","author":"Fedorov O.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nbt1358","volume":"26","author":"Karaman M. W.","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"7898","DOI":"10.1021\/jm8011036","volume":"51","author":"Bamborough P.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1021\/jm701399f","volume":"51","author":"Sutherland J. J.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1021\/jm901147e","volume":"52","author":"Vieth M.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/jm101195a","volume":"54","author":"Posy S. L.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12154-009-0023-9","volume":"2","author":"Smyth L.","year":"2009","journal-title":"J. Chem. Biol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrd2541","volume":"7","author":"Goldstein D. M.","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1186\/1471-2105-9-491","volume":"9","author":"Caffrey D.","year":"2008","journal-title":"BMC Bioinf."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1021\/mp800010p","volume":"5","author":"Zhang X.","year":"2008","journal-title":"Mol. Pharm."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1021\/ci800138n","volume":"48","author":"Sciabola S.","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1021\/ci900176y","volume":"49","author":"Sheridan R. P.","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/1471-2105-11-339","volume":"11","author":"Lapins M.","year":"2010","journal-title":"BMC Bioinf."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1021\/mp100179t","volume":"7","author":"Ma X. H.","year":"2010","journal-title":"Mol. Pharm."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1021\/jm8010542","volume":"52","author":"Bikker J. A.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref26\/cit26","volume-title":"Kinase SARfari","year":"2011"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/bioinformatics\/btp650","volume":"26","author":"Huang D.","year":"2010","journal-title":"Bioinformatics"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"W32","DOI":"10.1093\/nar\/gkl305","volume":"34","author":"Li Z. R.","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1021\/ci970429i","volume":"38","author":"Lewell X. Q.","year":"1998","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1747-0285.2008.00762.x","volume":"73","author":"Schreyer A.","year":"2009","journal-title":"Chem. Biol. Drug Des."},{"key":"ref31\/cit31","unstructured":"RDKit: Cheminformatics and Machine Learning Software, 2010."},{"key":"ref32\/cit32","volume-title":"Pipeline Pilot","year":"2007"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1021\/ci100050t","volume":"50","author":"Rogers D.","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1021\/jm030331x","volume":"47","author":"Deng Z.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1747-0285.2005.00323.x","volume":"67","author":"Singh J.","year":"2006","journal-title":"Chem. Biol. Drug Des."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1021\/ci800447g","volume":"49","author":"Weill N.","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"W424","DOI":"10.1093\/nar\/gkq480","volume":"38","author":"Chen Y.-F.","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2174\/138620709788489046","volume":"12","author":"Klon A. E.","year":"2009","journal-title":"Comb. Chem. High Throughput Screening"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-60761-839-3_7","volume":"672","author":"Bender A.","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1021\/jm0303195","volume":"47","author":"Xia X.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1021\/ci060003g","volume":"46","author":"Nidhi","year":"2006","journal-title":"J. Chem. Inf. Model."},{"key":"ref42\/cit42","volume-title":"Statistical Learning Theory","author":"Vapnik V. N.","year":"1998"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/ci050367t","volume":"46","author":"Erhan D.","year":"2006","journal-title":"J. Chem. Inf. Model."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/bioinformatics\/btn409","volume":"24","author":"Jacob L.","year":"2008","journal-title":"Bioinformatics"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1021\/ci800441c","volume":"49","author":"Wassermann A. M.","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.neunet.2005.07.009","volume":"18","author":"Ralaivola L.","year":"2005","journal-title":"Neural Networks"},{"key":"ref47\/cit47","volume-title":"Learning with Kernels: Support Vector Machines, Regularization, Optimization, and Beyond","author":"Sch\u00f6lkopf B.","year":"2002"},{"key":"ref48\/cit48","unstructured":"Chang, C.C. Lin, C.J.LIBSVM: a library for support vector machines; 2001."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1186\/1471-2105-8-438","volume":"8","author":"Caragea C.","year":"2007","journal-title":"BMC Bioinf."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jtbi.2010.01.013","volume":"264","author":"Xu Y.","year":"2010","journal-title":"J. Theor. Biol."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.neucom.2007.04.010","volume":"71","author":"Lauer F.","year":"2008","journal-title":"Neurocomputing"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1126\/science.1136800","volume":"315","author":"Frey B. J.","year":"2007","journal-title":"Science"},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1021\/ci060117s","volume":"46","author":"Maggiora G. M.","year":"2006","journal-title":"J. Chem. Inf. Model."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1021\/ci700332k","volume":"48","author":"Johnson S. R.","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/mp100423u","volume":"8","author":"Huang J.","year":"2011","journal-title":"Mol. Pharm."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.jmgm.2008.01.002","volume":"26","author":"Weaver S.","year":"2008","journal-title":"J. Mol. Graphics Modell."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1021\/ci025620t","volume":"43","author":"Warmuth M. K.","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nchembio.576","volume":"7","author":"Murphy R. F.","year":"2011","journal-title":"Nat. Chem. Biol."}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci200607f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T22:26:51Z","timestamp":1680647211000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci200607f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,26]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4,23]]}},"alternative-id":["10.1021\/ci200607f"],"URL":"https:\/\/doi.org\/10.1021\/ci200607f","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,26]]}}}