{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:03:36Z","timestamp":1758474216918,"version":"3.40.4"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2014,4,28]]},"DOI":"10.1021\/ci400723m","type":"journal-article","created":{"date-parts":[[2014,2,16]],"date-time":"2014-02-16T17:06:24Z","timestamp":1392570384000},"page":"1103-1116","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis, Bioassay, and Molecular Field Topology Analysis of Diverse Vasodilatory Heterocycles"],"prefix":"10.1021","volume":"54","author":[{"given":"Polina V.","family":"Oliferenko","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States"}]},{"given":"Alexander A.","family":"Oliferenko","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States"}]},{"given":"Adel S.","family":"Girgis","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States"}]},{"given":"Dalia O.","family":"Saleh","sequence":"additional","affiliation":[]},{"given":"Aladdin M.","family":"Srour","sequence":"additional","affiliation":[]},{"given":"Riham F.","family":"George","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt"}]},{"given":"Girinath G.","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States"},{"name":"Department of Chemistry, University of Tartu, Ravila 14a, Tartu 50411, Estonia"}]},{"given":"Chandramukhi S.","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States"}]},{"given":"C. Dennis","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States"}]},{"given":"Alan R.","family":"Katritzky","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States"},{"name":"Department of Chemistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}]}],"member":"316","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","volume":"365","author":"Kearney P. M.","year":"2005","journal-title":"Lancet"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1161\/01.HYP.26.1.60","volume":"26","author":"Burt V. L.","year":"1995","journal-title":"Hypertension"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1001\/jama.2010.650","volume":"303","author":"Egan B. M.","year":"2010","journal-title":"JAMA, J. Am. Med. Assoc."},{"volume-title":"Clinical Pharmacology and Therapeutics of Hypertension","year":"2008","author":"McInnes G. T.","key":"ref4\/cit4"},{"volume-title":"Cardiovascular Physiology Concepts","year":"2004","author":"Klabunde R. E.","key":"ref5\/cit5"},{"key":"ref6\/cit6a","doi-asserted-by":"crossref","first-page":"8488","DOI":"10.1016\/j.bmc.2006.08.041","volume":"14","author":"Girgis A. S.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref6\/cit6b","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1016\/j.bmc.2006.02.031","volume":"14","author":"Girgis A. S.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref6\/cit6c","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.ejmech.2007.11.025","volume":"43","author":"Girgis A. S.","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"ref6\/cit6d","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.ejmech.2011.03.023","volume":"46","author":"Girgis A. S.","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref6\/cit6e","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1016\/j.ejmech.2010.06.018","volume":"45","author":"Girgis A. S.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0223-5234(01)01277-6","volume":"36","author":"Badawneh M.","year":"2001","journal-title":"Eur. J. Med. Chem."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/molecules15010270","volume":"15","author":"Quezada E.","year":"2010","journal-title":"Molecules"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1016\/j.ejmech.2009.06.006","volume":"44","author":"Bansal R.","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1016\/j.bmc.2005.03.003","volume":"13","author":"Silva A. G.","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0960-894X(02)00015-X","volume":"12","author":"Campos-Toimil M.","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1021\/jm9002236","volume":"52","author":"Chegaev K.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/qsar.200630006","volume":"26","author":"Vilar S.","year":"2007","journal-title":"QSAR Comb. Sci."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bmc.2007.09.031","volume":"16","author":"Abouzid K.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"8257","DOI":"10.3390\/molecules16108257","volume":"16","author":"Dong X.","year":"2011","journal-title":"Molecules"},{"key":"ref16\/cit16a","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1021\/ci980114i","volume":"40","author":"Palyulin V. A.","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref16\/cit16b","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10631-005-0039-9","volume":"402","author":"Palyulin V. A.","year":"2005","journal-title":"Dokl. Chem."},{"key":"ref17\/cit17a","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1021\/jm070679i","volume":"50","author":"Zhan W.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref17\/cit17b","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/cplu.201200038","volume":"77","author":"Berhanu W. M.","year":"2012","journal-title":"ChemPlusChem"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1134\/S1607672908010122","volume":"418","author":"Radchenko E. V.","year":"2008","journal-title":"Dokl. Biochem. Biophys."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1134\/S0012500808090073","volume":"422","author":"Chupakhin V. I.","year":"2008","journal-title":"Dokl. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"4964","DOI":"10.1016\/j.ejmech.2011.07.058","volume":"46","author":"Girgis A. S.","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejmech.2013.01.042","volume":"63","author":"Nofal Z. M.","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bmcl.2005.10.013","volume":"16","author":"Vilar S.","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0014-2999(99)00323-4","volume":"374","author":"Burns D. M.","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/sj.bjp.0707331","volume":"151","author":"Eguchi S.","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0022-3565(24)29359-9","volume":"298","author":"Si M.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1291\/hypres.28.689","volume":"28","author":"Toba H.","year":"2005","journal-title":"Hypertens. Res."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1021\/jm00360a013","volume":"26","author":"Clark R. D.","year":"1983","journal-title":"J. Med. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0223-5234(99)80099-3","volume":"34","author":"Ferrarini P. L.","year":"1999","journal-title":"Eur. J. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/sj.bjp.0704473","volume":"135","author":"Silva C. L. M.","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1289\/ehp.8561239","volume":"61","author":"Franke R.","year":"1985","journal-title":"Environ. Health Persp."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1002\/(SICI)1521-3773(19991004)38:19<2894::AID-ANIE2894>3.0.CO;2-F","volume":"38","author":"Schneider G.","year":"1999","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1021\/ci6002416","volume":"46","author":"Bonachera F.","year":"2006","journal-title":"J. Chem. Inf. Model."},{"volume-title":"Topological pharmacophores, Ch. 2 in Chemoinformatics Approaches to Virtual Screening","year":"2008","author":"Horvath D.","key":"ref33\/cit33"},{"key":"ref34\/cit34","first-page":"365","volume":"143","author":"Girgis A. S.","year":"2004","journal-title":"Boll. Chim. Farm."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00726-003-0051-7","volume":"26","author":"Girgis A. S.","year":"2004","journal-title":"Amino Acids"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2011.11.034","volume":"50","author":"Girgis A. S.","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ejmech.2010.11.045","volume":"46","author":"Abou-Seri S. M.","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1155\/2010\/404715","volume":"7","author":"Ramesh B.","year":"2010","journal-title":"E-J. Chem."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/ardp.200400935","volume":"338","author":"Turan-Zitouni G.","year":"2005","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/ardp.2503240908","volume":"324","author":"Greiner-Bechert L.","year":"1991","journal-title":"Arch. Pharm. (Weinheim, Ger.)"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci400723m","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T21:29:43Z","timestamp":1746134983000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci400723m"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,9]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4,28]]}},"alternative-id":["10.1021\/ci400723m"],"URL":"https:\/\/doi.org\/10.1021\/ci400723m","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"type":"print","value":"1549-9596"},{"type":"electronic","value":"1549-960X"}],"subject":[],"published":{"date-parts":[[2014,4,9]]}}}