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Chem."},{"key":"ref59\/cit59","unstructured":"Canvas software;Schr\u00f6dinger LLC:New York, 2010."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ejmech.2013.02.033","volume":"63","author":"Wrobel M. Z.","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","volume":"22","author":"Cheng Y.","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"D1100","DOI":"10.1093\/nar\/gkr777","volume":"40","author":"Gaulton A.","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1074\/jbc.M109.072587","volume":"285","author":"Andersen J.","year":"2010","journal-title":"J. Biol. 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