{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:57:49Z","timestamp":1790593069490,"version":"4.1.0"},"reference-count":82,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease (AD) is one of the most complicated progressive neurodegeneration diseases that involve many genes, proteins, and their complex interactions. No effective medicines or treatments are available yet to stop or reverse the progression of the disease due to its polygenic nature. To facilitate discovery of new AD drugs and better understand the AD neurosignaling pathways involved, we have constructed an Alzheimer\u2019s disease domain-specific chemogenomics knowledgebase, AlzPlatform (www.cbligand.org\/AD\/) with cloud computing and sourcing functions. AlzPlatform is implemented with powerful computational algorithms, including our established TargetHunter, HTDocking, and BBB Predictor for target identification and polypharmacology analysis for AD research. The platform has assembled various AD-related chemogenomics data records, including 928 genes and 320 proteins related to AD, 194 AD drugs approved or in clinical trials, and 405\u2009188 chemicals associated with 1\u2009023\u2009137 records of reported bioactivities from 38\u2009284 corresponding bioassays and 10\u2009050 references. Furthermore, we have demonstrated the application of the AlzPlatform in three case studies for identification of multitargets and polypharmacology analysis of FDA-approved drugs and also for screening and prediction of new AD active small chemical molecules and potential novel AD drug targets by our established TargetHunter and\/or HTDocking programs. The predictions were confirmed by reported bioactivity data and our in vitro experimental validation. Overall, AlzPlatform will enrich our knowledge for AD target identification, drug discovery, and polypharmacology analyses and, also, facilitate the chemogenomics data sharing and information exchange\/communications in aid of new anti-AD drug discovery and development.<\/jats:p>","DOI":"10.1021\/ci500004h","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T18:51:35Z","timestamp":1394045495000},"page":"1050-1060","source":"Crossref","is-referenced-by-count":209,"title":["AlzPlatform:\nAn Alzheimer\u2019s Disease Domain-Specific Chemogenomics Knowledgebase\nfor Polypharmacology and Target Identification Research"],"prefix":"10.1021","volume":"54","author":[{"given":"Haibin","family":"Liu","sequence":"first","affiliation":[{"name":"University of Pittsburgh ; , , ,","place":["Pittsburgh, Pennsylvania, United States, 15260"]},{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, P.R. China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Pittsburgh ; , , ,","place":["Pittsburgh, Pennsylvania, United States, 15260"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingliang","family":"Lv","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, P.R. China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Pei","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, P.R. China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peibo","family":"Li","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, P.R. China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Pei","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, P.R. China, 510080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Wang","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, P.R. China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Su","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , ,","place":["Guangzhou, P.R. China, 510275"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Qun","family":"Xie","sequence":"additional","affiliation":[{"name":"University of Pittsburgh ; , , ,","place":["Pittsburgh, Pennsylvania, United States, 15260"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,3,5]]},"reference":[{"key":"2026092806091731800_cit1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"New\nEngl. J. Med."},{"key":"2026092806091731800_cit2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jalz.2010.01.010","article-title":"The worldwide societal costs of dementia: Estimates\nfor 2009","volume":"6","author":"Wimo","year":"2010","journal-title":"Alzheimer\u2019s Dementia: J. Alzheimer\u2019s\nAssoc."},{"key":"2026092806091731800_cit3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and\naway from Alzheimer\u2019s disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"2026092806091731800_cit4","doi-asserted-by":"crossref","first-page":"R148","DOI":"10.1186\/gb-2008-9-10-r148","article-title":"Variations\nin the transcriptome of Alzheimer\u2019s disease reveal molecular\nnetworks involved in cardiovascular diseases","volume":"9","author":"Ray","year":"2008","journal-title":"Genome Biol."},{"key":"2026092806091731800_cit5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2047-9158-1-18","article-title":"Advances in the pathogenesis of Alzheimer\u2019s disease: a re-evaluation\nof amyloid cascade hypothesis","volume":"1","author":"Dong","year":"2012","journal-title":"Translational\nNeurodegeneration"},{"key":"2026092806091731800_cit6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of Alzheimer\ndisease genetic association studies: the AlzGene database","volume":"39","author":"Bertram","year":"2007","journal-title":"Nat. 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Endocrinol."},{"key":"2026092806091731800_cit28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejphar.2008.12.044","article-title":"Pharmacological\ncomparison of muscarinic ligands: historical versus more recent muscarinic\nM1-preferring receptor agonists","volume":"605","author":"Heinrich","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"2026092806091731800_cit29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1515\/bc.2010.089","article-title":"Is BACE1\na suitable therapeutic target for the treatment of Alzheimer\u2019s\ndisease? Current strategies and future directions","volume":"391","author":"Klaver","year":"2010","journal-title":"Biol. 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