{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:55:52Z","timestamp":1778680552308,"version":"3.51.4"},"reference-count":87,"publisher":"American Chemical Society (ACS)","issue":"4","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373281"],"award-info":[{"award-number":["81373281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["IRT13028"],"award-info":[{"award-number":["IRT13028"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NCET-12-0337"],"award-info":[{"award-number":["NCET-12-0337"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Natural Science Fund for Distinguished Young Scholars","award":["JQ201319"],"award-info":[{"award-number":["JQ201319"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2015,4,27]]},"DOI":"10.1021\/ci500762z","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T18:07:10Z","timestamp":1426010830000},"page":"861-871","source":"Crossref","is-referenced-by-count":43,"title":["Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8"],"prefix":"10.1021","volume":"55","author":[{"given":"Xuben","family":"Hou","sequence":"first","affiliation":[{"name":"Department\rof Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural\rProducts (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China"}]},{"given":"Jintong","family":"Du","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, China"}]},{"given":"Renshuai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department\rof Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural\rProducts (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department\rof Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural\rProducts (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China"}]},{"given":"Minyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department\rof Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural\rProducts (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China"}]},{"given":"Wenfang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department\rof Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural\rProducts (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China"}]},{"given":"Hao","family":"Fang","sequence":"additional","affiliation":[{"name":"Department\rof Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural\rProducts (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China"}]}],"member":"316","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nm.2305","volume":"17","author":"Rodriguez-Paredes M.","year":"2011","journal-title":"Nat. Med."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nrd3674","volume":"11","author":"Arrowsmith C. H.","year":"2012","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/38664","volume":"389","author":"Grunstein M.","year":"1997","journal-title":"Nature"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1175371","volume":"325","author":"Choudhary C.","year":"2009","journal-title":"Science"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gene.2005.09.010","volume":"363","author":"Glozak M. A.","year":"2005","journal-title":"Gene"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1073\/pnas.0307708100","volume":"101","author":"Gui C. Y.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1126\/science.1179689","volume":"327","author":"Zhao S.","year":"2010","journal-title":"Science"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1038\/sj.onc.1210599","volume":"26","author":"Yang X. J.","year":"2007","journal-title":"Oncogene"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1039\/b703830p","volume":"37","author":"Bieliauskas A. V.","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.1021\/jm400634n","volume":"56","author":"Marson C. M.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"6936","DOI":"10.1021\/jm0505011","volume":"48","author":"Wang D. F.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1021\/ci900288e","volume":"49","author":"Ortore G.","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1021\/jm401837e","volume":"57","author":"Wambua M. K.","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1200\/JCO.2009.22.1291","volume":"27","author":"Lane A. A.","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nbt0107-17","volume":"25","author":"Garber K.","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/med.21320","volume":"35","author":"Zhang L.","year":"2015","journal-title":"Med. Res. Rev."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1021\/jm7011408","volume":"51","author":"Paris M.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.bcp.2007.04.007","volume":"74","author":"Glaser K. B.","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.3109\/10428194.2013.877134","volume":"55","author":"Kirschbaum M. H.","year":"2014","journal-title":"Leuk. Lymphoma"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s13148-010-0012-4","volume":"1","author":"Wagner J. M.","year":"2010","journal-title":"Clin. Epigenet."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1021\/jm3017199","volume":"56","author":"Lavecchia A.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1021\/jm3013486","volume":"56","author":"Alcaro S.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1021\/ml400226s","volume":"4","author":"Osolodkin D. I.","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chembiol.2010.03.006","volume":"17","author":"Bowers E. M.","year":"2010","journal-title":"Chem. Biol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"9309","DOI":"10.1021\/jm500692u","volume":"57","author":"Hou X.","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1021\/jm401908w","volume":"57","author":"Xu L.","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1073\/pnas.0609757104","volume":"104","author":"Siddiquee K.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"8461","DOI":"10.1021\/jm101020z","volume":"53","author":"Ripphausen P.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.drudis.2010.03.013","volume":"15","author":"Yang S. Y.","year":"2010","journal-title":"Drug Discovery Today"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1021\/jm900817u","volume":"53","author":"Leach A. R.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1021\/ci300417y","volume":"53","author":"Hou X. B.","year":"2013","journal-title":"J. Chem. Inf. Model."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1021\/ci8004429","volume":"49","author":"Zhang X.","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1021\/ci300493w","volume":"53","author":"Li G. B.","year":"2013","journal-title":"J. Chem. Inf. Model."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1021\/ci500414b","volume":"54","author":"Tian S.","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.4155\/fmc.12.148","volume":"4","author":"Hahnke V.","year":"2012","journal-title":"Future Med. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1021\/ci700130j","volume":"48","author":"Moffat K.","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1021\/ci400644r","volume":"54","author":"Therese P. J.","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"440","DOI":"10.2174\/092986611794927992","volume":"18","author":"Hou X.","year":"2011","journal-title":"Protein Pept. Lett."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/ci800366f","volume":"49","author":"Tang H.","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/cmdc.200900500","volume":"5","author":"Park H.","year":"2010","journal-title":"ChemMedChem"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ymeth.2014.11.010","volume":"71","author":"Li G. B.","year":"2015","journal-title":"Methods"},{"key":"ref42\/cit42","first-page":"812148","volume":"2014","author":"Kandakatla N.","year":"2014","journal-title":"Adv. Bioinf."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1021\/ci500209e","volume":"54","author":"Santos-Martins D.","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1021\/ci400550m","volume":"54","author":"Pottel J.","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1021\/ci5004152","volume":"54","author":"Chaskar P.","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1016\/j.ejmech.2010.06.024","volume":"45","author":"Thangapandian S.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.jmgm.2007.10.007","volume":"26","author":"Chen Y. D.","year":"2008","journal-title":"J. Mol. Graphics Modell."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1016\/j.ejmech.2008.12.008","volume":"44","author":"Chen Y. D.","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"7997","DOI":"10.1021\/jm401053m","volume":"56","author":"Day J. A.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1021\/jo400406g","volume":"78","author":"Chen K.","year":"2013","journal-title":"J. Org. Chem."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1016\/j.bmcl.2008.10.041","volume":"18","author":"Scarpelli R.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"6782","DOI":"10.1021\/jm900555u","volume":"52","author":"Ontoria J. M.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1021\/jm301769u","volume":"56","author":"Patil V.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"9969","DOI":"10.1021\/jm401225q","volume":"56","author":"Sodji Q. H.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1021\/ml400158k","volume":"4","author":"Ononye S. N.","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1021\/jo070739s","volume":"72","author":"Wang D.","year":"2007","journal-title":"J. Org. Chem."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"6070","DOI":"10.1016\/j.bmc.2005.06.009","volume":"13","author":"Vanommeslaeghe K.","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1747-0285.2012.01382.x","volume":"80","author":"McCarren P.","year":"2012","journal-title":"Chem. Biol. Drug Des."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"15064","DOI":"10.1073\/pnas.0404603101","volume":"101","author":"Vannini A.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0002-9440(10)63320-2","volume":"165","author":"Waltregny D.","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1016\/j.bmc.2010.03.080","volume":"18","author":"Estiu G.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1021\/bi1005046","volume":"49","author":"Dowling D. P.","year":"2010","journal-title":"Biochemistry"},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1021\/bi500711x","volume":"53","author":"Singh R. K.","year":"2014","journal-title":"Biochemistry"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1021\/ja111104p","volume":"133","author":"Wu R.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"17862","DOI":"10.1021\/ja408184x","volume":"135","author":"Kunze M. B.","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"11636","DOI":"10.1021\/ja501548p","volume":"136","author":"Chen K.","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"9471","DOI":"10.1021\/ja103932d","volume":"132","author":"Wu R.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1021\/ct9005322","volume":"6","author":"Wu R.","year":"2009","journal-title":"J. Chem. Theory Comput."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1021\/jm300687e","volume":"55","author":"Mysinger M. M.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/ci049714+","volume":"45","author":"Irwin J. J.","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"388","DOI":"10.2174\/138920107783018417","volume":"8","author":"Bruserud O.","year":"2007","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1124\/mol.104.005553","volume":"67","author":"Erbe D. V.","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1742-4658.2012.08718.x","volume":"280","author":"He R.","year":"2013","journal-title":"FEBS J."},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.embor.7401047","volume":"8","author":"Vannini A.","year":"2007","journal-title":"EMBO Rep."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1016\/j.bmc.2011.06.030","volume":"19","author":"Whitehead L.","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"13554","DOI":"10.1021\/bi801610c","volume":"47","author":"Dowling D. P.","year":"2008","journal-title":"Biochemistry"},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1021\/jm101605z","volume":"54","author":"Zhang Y.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1021\/jm020406h","volume":"46","author":"Jain A. N.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10822-011-9533-y","volume":"26","author":"Spitzer R.","year":"2012","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","volume":"29","author":"Pronk S.","year":"2013","journal-title":"Bioinformatics"},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","volume":"26","author":"Van Der Spoel D.","year":"2005","journal-title":"J. Comput. Chem."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/prot.22711","volume":"78","author":"Lindorff-Larsen K.","year":"2010","journal-title":"Proteins"},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"5 6 1","DOI":"10.1002\/0471250953.bi0506s47","volume":"47","author":"Webb B.","year":"2014","journal-title":"Curr. Protoc. Bioinf."},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1021\/ct9001015","volume":"5","author":"Cerutti D. S.","year":"2009","journal-title":"J. Chem. Theory Comput."},{"key":"ref85\/cit85","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1021\/ct700200b","volume":"4","author":"Hess B.","year":"2008","journal-title":"J. Chem. Theory Comput."},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1107\/S0907444904011679","volume":"60","author":"Schuttelkopf A. W.","year":"2004","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"W368","DOI":"10.1093\/nar\/gki464","volume":"33","author":"Gordon J. C.","year":"2005","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci500762z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T11:18:42Z","timestamp":1682248722000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci500762z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,16]]},"references-count":87,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4,27]]}},"alternative-id":["10.1021\/ci500762z"],"URL":"https:\/\/doi.org\/10.1021\/ci500762z","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,16]]}}}