{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:54:54Z","timestamp":1772132094817,"version":"3.50.1"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2006,11,1]]},"DOI":"10.1021\/ci600188h","type":"journal-article","created":{"date-parts":[[2006,10,15]],"date-time":"2006-10-15T07:59:42Z","timestamp":1160899182000},"page":"2563-2573","source":"Crossref","is-referenced-by-count":3,"title":["A Novel Method to Simulate the Hydrophobic Effect and Its Application to the Ranking of Host\/Guest Complexes"],"prefix":"10.1021","volume":"46","author":[{"given":"Arthur M.","family":"Doweyko","sequence":"first","affiliation":[{"name":"Computer-Assisted Drug Design, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey 08543"}]},{"given":"Stephen R.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Computer-Assisted Drug Design, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey 08543"}]}],"member":"316","published-online":{"date-parts":[[2006,10,14]]},"reference":[{"key":"ci600188hb00001\/ci600188hb00001_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature04162","volume":"437","author":"Chandler D","year":"2005","journal-title":"Nature (London)"},{"key":"ci600188hb00002\/ci600188hb00002_1","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.2174\/0929867043363929","volume":"11","author":"Cozzini P.","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"ci600188hb00003\/ci600188hb00003_1","volume":"34","author":"Dill K. A.","year":"2005","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"ci600188hb00004\/ci600188hb00004_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/jp020104r","volume":"106","author":"Southall N. T.","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ci600188hb00005\/ci600188hb00005_1","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1039\/b304038k","volume":"5","author":"Widom B.","year":"2003","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ci600188hb00006\/ci600188hb00006_1","first-page":"2053","volume":"106","author":"Huang D. M.","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ci600188hb00007\/ci600188hb00007_1","doi-asserted-by":"crossref","first-page":"9744","DOI":"10.1063\/1.1697379","volume":"120","author":"Jensen M. O.","year":"2004","journal-title":"J. Chem. Phys."},{"key":"ci600188hb00008\/ci600188hb00008_1","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1021\/jm049524q","volume":"48","author":"Kelly M. D.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ci600188hb00009\/ci600188hb00009_1","first-page":"23617","volume":"109","author":"Xu H.","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"ci600188hb00010\/ci600188hb00010_1","doi-asserted-by":"crossref","first-page":"9860","DOI":"10.1021\/ja029796n","volume":"125","author":"Gallagher K. R.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ci600188hb00011\/ci600188hb00011_1","volume-title":"229th ACS National Meeting","author":"Eads C. D.","year":"2005"},{"key":"ci600188hb00012\/ci600188hb00012_1","volume":"122","author":"Imai T.","year":"2005","journal-title":"J. Chem. Phys."},{"key":"ci600188hb00013\/ci600188hb00013_1","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1063\/1.1590645","volume":"119","author":"Buzano C.","year":"2003","journal-title":"J. Chem. Phys."},{"key":"ci600188hb00014\/ci600188hb00014_1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1134\/1.2149075","volume":"101","author":"Sitnikov G. V.","year":"2005","journal-title":"J. Exp. Theor. Phys."},{"key":"ci600188hb00015\/ci600188hb00015_1","first-page":"532","volume":"13","author":"Frank H. S.","year":"1945","journal-title":"J. Chem. Phys."},{"key":"ci600188hb00016\/ci600188hb00016_1","first-page":"2892","volume":"99","author":"Wallqvist A.","year":"1995","journal-title":"J. Phys. Chem."},{"key":"ci600188hb00017\/ci600188hb00017_1","first-page":"11409","volume":"126","author":"Gibb C. L. D.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ci600188hb00018\/ci600188hb00018_1","volume-title":"Funct., Genet.","author":"Scarsi M.","year":"1999"},{"key":"ci600188hb00020\/ci600188hb00020_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman H. M.","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ci600188hb00021\/ci600188hb00021_1","first-page":"2303","volume":"46","author":"Wang R.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ci600188hb00022\/ci600188hb00022_1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1006\/jmbi.1996.0897","volume":"267","author":"Jones G.","year":"1997","journal-title":"J. Mol. Biol."},{"key":"ci600188hb00023\/ci600188hb00023_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1023\/A:1007907728892","volume":"11","author":"McMartin C.","year":"1997","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ci600188hb00024\/ci600188hb00024_1","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1021\/ct050164b","volume":"1","author":"Kelly C. P.","year":"2005","journal-title":"J. Chem. Theory Comput."},{"key":"ci600188hb00025\/ci600188hb00025_1","volume-title":"version. 7.5","author":"Maestro"},{"key":"ci600188hb00026\/ci600188hb00026_1","volume-title":"version 9.1","author":"MacroModel"},{"key":"ci600188hb00027\/ci600188hb00027_1","volume-title":"version 6.5","author":"Jaguar"},{"key":"ci600188hb00028\/ci600188hb00028_1","doi-asserted-by":"crossref","first-page":"11788","DOI":"10.1021\/jp953087x","volume":"100","author":"Marten B.","year":"1996","journal-title":"J. Phys. Chem."},{"key":"ci600188hb00029\/ci600188hb00029_1","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1021\/jp9705075","volume":"101","author":"Florian J.","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"ci600188hb00030\/ci600188hb00030_1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1021\/cr60304a002","volume":"76","author":"Pierotti R. A","year":"1976","journal-title":"Chem. Rev."},{"key":"ci600188hb00031\/ci600188hb00031_1","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1063\/1.1676598","volume":"55","author":"Stillinger F. H.","year":"1971","journal-title":"J. Chem. Phys."},{"key":"ci600188hb00032\/ci600188hb00032_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF00651970","volume":"2","author":"Stillinger F. H","year":"1973","journal-title":"J. Solution Chem."},{"key":"ci600188hb00033\/ci600188hb00033_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/jcc.540100504","volume":"10","author":"Floris F.","year":"1989","journal-title":"J. Comput. Chem."},{"key":"ci600188hb00034\/ci600188hb00034_1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/BF00126219","volume":"6","author":"Cramer C. J.","year":"1992","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ci600188hb00035\/ci600188hb00035_1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/jcc.540130907","volume":"13","author":"Cramer C. J.","year":"1992","journal-title":"J. Comput. Chem."},{"key":"ci600188hb00036\/ci600188hb00036_1","volume-title":"Reconciling and Magnitude of the Microscopic and Macroscopic Hydrophobic Effects. Chemtracts:\u2009 Org. Chem","author":"Whitesides G. M.","year":"1992"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci600188h","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T02:04:07Z","timestamp":1678845847000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci600188h"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,14]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,11,1]]}},"alternative-id":["10.1021\/ci600188h"],"URL":"https:\/\/doi.org\/10.1021\/ci600188h","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1058803.510732","asserted-by":"object"}]},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,14]]}}}