{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:27:44Z","timestamp":1759332464429},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2007,3,1]]},"DOI":"10.1021\/ci6004367","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T16:37:59Z","timestamp":1169829479000},"page":"635-643","source":"Crossref","is-referenced-by-count":9,"title":["Perspective Assessment of COX-1 and COX-2 Selectivity of Nonsteroidal Anti-Inflammatory Drugs from Clinical Practice:\u2009 Use of Genetic Function Approximation"],"prefix":"10.1021","volume":"47","author":[{"given":"Ajit P.","family":"Zambre","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune 411 038, India, and Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok L.","family":"Ganure","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune 411 038, India, and Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devanand B.","family":"Shinde","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune 411 038, India, and Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vithal M.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune 411 038, India, and Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2007,1,26]]},"reference":[{"key":"ci6004367b00001\/ci6004367b00001_1","first-page":"657","volume-title":"The Pharmacological Basis of Therapeutics","author":"Insel P. A.","year":"1996","edition":"9"},{"key":"ci6004367b00002\/ci6004367b00002_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/newbio231235a0","volume":"231","author":"Vane J. R","year":"1971","journal-title":"Nature New Biol."},{"key":"ci6004367b00003\/ci6004367b00003_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0165-6147(99)01385-1","volume":"20","author":"Marnett L. J.","year":"1999","journal-title":"Trends Pharm. Sci."},{"key":"ci6004367b00004\/ci6004367b00004_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1056\/NEJM199209103271101","volume":"327","author":"Allison M. C.","year":"1992","journal-title":"New Engl. J. Med."},{"key":"ci6004367b00005\/ci6004367b00005_1","first-page":"181","volume":"63","author":"Garell S.","year":"1984","journal-title":"Medicine"},{"key":"ci6004367b00006\/ci6004367b00006_1","first-page":"7568","volume":"96","author":"Warner T. D.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ci6004367b00007\/ci6004367b00007_1","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1021\/jm960803q","volume":"40","author":"Penning T. D.","year":"1997","journal-title":"J. Med. Chem."},{"key":"ci6004367b00008\/ci6004367b00008_1","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/S0960-894X(99)00288-7","volume":"9","author":"Prasit P.","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ci6004367b00009\/ci6004367b00009_1","first-page":"777","volume":"43","author":"Talley J. J.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ci6004367b00010\/ci6004367b00010_1","first-page":"1663","volume":"43","author":"Talley J. J.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ci6004367b00011\/ci6004367b00011_1","first-page":"566","volume":"296","author":"Riendeau D.","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ci6004367b00012\/ci6004367b00012_1","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1161\/01.CIR.0000127578.21885.3E","volume":"109","author":"Solomon D. H.","year":"2004","journal-title":"Circulation"},{"key":"ci6004367b00013\/ci6004367b00013_1","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3390\/50700945","volume":"5","author":"Desiraju G. R.","year":"2000","journal-title":"Molecules"},{"key":"ci6004367b00014\/ci6004367b00014_1","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1021\/jm0101343","volume":"44","author":"Chavatte P.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ci6004367b00015\/ci6004367b00015_1","first-page":"261","volume":"2","author":"Raichurkar A. V.","year":"2003","journal-title":"Int. Electron. J. Mol. Des."},{"key":"ci6004367b00016\/ci6004367b00016_1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nsb1196-927","volume":"3","author":"Luong C.","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"ci6004367b00017\/ci6004367b00017_1","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1016\/S0968-0896(00)00178-4","volume":"8","author":"Gokhale V. M.","year":"2000","journal-title":"Bioorg. Med. Chem."},{"key":"ci6004367b00018\/ci6004367b00018_1","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1016\/S0968-0896(01)00186-9","volume":"9","author":"Karki R. G.","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"ci6004367b00019\/ci6004367b00019_1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/S0968-0896(01)00415-1","volume":"10","author":"Makhija M. T.","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"ci6004367b00020\/ci6004367b00020_1","first-page":"609","volume":"3","author":"Vadlamudi S. M.","year":"2004","journal-title":"Int. Electron. J. Mol. Des."},{"key":"ci6004367b00021\/ci6004367b00021_1","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1021\/jm020217z","volume":"45","author":"Kharkar P. S.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ci6004367b00022\/ci6004367b00022_1","volume-title":"Genetic Algorithm. In Proceedings of the Fourth International Conference on Genetic Algorithms","author":"Rogers D.","year":"1991"},{"key":"ci6004367b00023\/ci6004367b00023_1","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1021\/ci00020a020","volume":"34","author":"Rogers D.","year":"1994","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci6004367b00024\/ci6004367b00024_1","volume-title":"version 3.5","author":"Cerius"},{"key":"ci6004367b00025\/ci6004367b00025_1","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1021\/jm980515p","volume":"42","author":"Venkatarangan P.","year":"1999","journal-title":"J. Med. Chem."},{"key":"ci6004367b00026\/ci6004367b00026_1","first-page":"811","volume":"37","author":"Tokarski J. S.","year":"1997","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci6004367b00027\/ci6004367b00027_1","first-page":"2102","volume":"38","author":"Hann M.","year":"1995","journal-title":"J. Med. Chem."},{"key":"ci6004367b00028\/ci6004367b00028_1","first-page":"3263","volume":"44","author":"Fan Y.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ci6004367b00029\/ci6004367b00029_1","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1021\/j100161a070","volume":"95","author":"Rappe A. K.","year":"1991","journal-title":"J. Phy. Chem."},{"key":"ci6004367b00030\/ci6004367b00030_1","doi-asserted-by":"crossref","first-page":"7206","DOI":"10.1021\/ja00544a005","volume":"102","author":"Hopfinger A. J","year":"1980","journal-title":"J. Am. Chem. Soc."},{"key":"ci6004367b00031\/ci6004367b00031_1","first-page":"4160","volume":"36","author":"Waller C. L.","year":"1993","journal-title":"J. Med. Chem."},{"key":"ci6004367b00032\/ci6004367b00032_1","first-page":"25","volume":"7","author":"Cramer R. D., III.","year":"1988","journal-title":"Quant. Struct.-Act. Relat."},{"key":"ci6004367b00033\/ci6004367b00033_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1021\/ci00063a007","volume":"29","author":"Viswanathan V. M.","year":"1989","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci6004367b00034\/ci6004367b00034_1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/384644a0","volume":"384","author":"Kurumbail R. G.","year":"1996","journal-title":"Nature"},{"key":"ci6004367b00035\/ci6004367b00035_1","doi-asserted-by":"crossref","first-page":"15814","DOI":"10.1074\/jbc.271.26.15810","volume":"271","author":"Gierse J. K.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ci6004367b00036\/ci6004367b00036_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S1367-5931(98)80124-5","volume":"2","author":"Marnett L. J.","year":"1998","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ci6004367b00037\/ci6004367b00037_1","first-page":"4593","volume":"43","author":"Bernard P.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ci6004367b00038\/ci6004367b00038_1","doi-asserted-by":"crossref","first-page":"9466","DOI":"10.1021\/ja001018c","volume":"122","author":"Plount Price M. L.","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ci6004367b00039\/ci6004367b00039_1","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1016\/S0960-894X(99)00481-3","volume":"9","author":"Llorens O.","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ci6004367b00040\/ci6004367b00040_1","first-page":"3042","volume":"44","author":"Habbeb A. G.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ci6004367b00041\/ci6004367b00041_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2477\/jchemsoft.5.147","volume":"5","author":"Akaho E.","year":"1999","journal-title":"J. Chem. Software"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci6004367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T03:54:45Z","timestamp":1678852485000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci6004367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,26]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,3,1]]}},"alternative-id":["10.1021\/ci6004367"],"URL":"https:\/\/doi.org\/10.1021\/ci6004367","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,26]]}}}