{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:13:29Z","timestamp":1768353209997,"version":"3.49.0"},"reference-count":15,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2008,2,1]]},"DOI":"10.1021\/ci700262y","type":"journal-article","created":{"date-parts":[[2008,1,23]],"date-time":"2008-01-23T12:00:25Z","timestamp":1201089625000},"page":"364-369","source":"Crossref","is-referenced-by-count":28,"title":["Novel Hierarchical Classification and Visualization Method for Multiobjective Optimization of Drug Properties:\u2009 Application to Structure\u2212Activity Relationship Analysis of Cytochrome P450 Metabolism"],"prefix":"10.1021","volume":"48","author":[{"given":"Fumiyoshi","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan, and Department of Information Sciences, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan"}]},{"given":"Hideto","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan, and Department of Information Sciences, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan"}]},{"given":"Takayuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan, and Department of Information Sciences, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan"}]},{"given":"Mitsuru","family":"Hashida","sequence":"additional","affiliation":[{"name":"Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan, and Department of Information Sciences, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan"}]}],"member":"316","published-online":{"date-parts":[[2008,1,23]]},"reference":[{"key":"ci700262yb00001\/ci700262yb00001_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1359-6446(03)02649-7","volume":"8","author":"Kerns E. H.","year":"2003","journal-title":"Drug Discovery Today"},{"key":"ci700262yb00002\/ci700262yb00002_1","first-page":"366","volume":"6","author":"Li A. P","year":"2001","journal-title":"Drug Discovery Today"},{"key":"ci700262yb00003\/ci700262yb00003_1","first-page":"861","volume":"8","author":"Yu H.","year":"2003","journal-title":"Drug Discovery Today"},{"key":"ci700262yb00004\/ci700262yb00004_1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1021\/ci9903049","volume":"39","author":"Rusinko A.","year":"1999","journal-title":"J. Chem. Inf. Comput Sci."},{"key":"ci700262yb00005\/ci700262yb00005_1","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1021\/jm060076r","volume":"49","author":"Ekins S.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ci700262yb00006\/ci700262yb00006_1","first-page":"1640","volume":"20","author":"Xia X.","year":"2003","journal-title":"Pharm. Res."},{"key":"ci700262yb00007\/ci700262yb00007_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/jps.10321","volume":"92","author":"Zmuidinavicius D.","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"ci700262yb00008\/ci700262yb00008_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1109\/MCG.2006.34","volume":"26","author":"Itoh T.","year":"2006","journal-title":"IEEE Comput. Graph. Appl."},{"key":"ci700262yb00009\/ci700262yb00009_1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1021\/ci0504770","volume":"46","author":"Yamashita F.","year":"2006","journal-title":"J. Chem. Inf. Model."},{"key":"ci700262yb00010\/ci700262yb00010_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1081\/DMR-120001392","volume":"34","author":"Rendic S","year":"2002","journal-title":"Drug Metab. Rev."},{"key":"ci700262yb00011\/ci700262yb00011_1","first-page":"390","volume":"35","author":"Lin J. H.","year":"1998","journal-title":"Clin. Pharmacokinet."},{"key":"ci700262yb00012\/ci700262yb00012_1","first-page":"1116","volume":"23","author":"Lin J. H","year":"2006","journal-title":"Pharm. Res."},{"key":"ci700262yb00013\/ci700262yb00013_1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.2165\/00003088-200140090-00001","volume":"40","author":"Bonnabry P.","year":"2001","journal-title":"Clin. Pharmacokinet."},{"key":"ci700262yb00014\/ci700262yb00014_1","first-page":"486","volume":"2","author":"Smith D. A.","year":"1997","journal-title":"Drug Discovery Today"},{"key":"ci700262yb00015\/ci700262yb00015_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0006-2952(00)00335-X","volume":"60","author":"Lewis D. F","year":"2000","journal-title":"Biochem. Pharmacol."}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci700262y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T20:29:51Z","timestamp":1680467391000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci700262y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,23]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2,1]]}},"alternative-id":["10.1021\/ci700262y"],"URL":"https:\/\/doi.org\/10.1021\/ci700262y","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,23]]}}}