{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T02:20:36Z","timestamp":1697595636287},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2008,4,1]]},"DOI":"10.1021\/ci700396b","type":"journal-article","created":{"date-parts":[[2008,3,14]],"date-time":"2008-03-14T05:00:47Z","timestamp":1205470847000},"page":"811-816","source":"Crossref","is-referenced-by-count":5,"title":["Hydra: A Self Regenerating High Performance Computing Grid for Drug Discovery"],"prefix":"10.1021","volume":"48","author":[{"given":"Drew","family":"Bullard","sequence":"first","affiliation":[{"name":"Anadys Pharmaceuticals, San Diego, California 92121"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Anadys Pharmaceuticals, San Diego, California 92121"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Lardy","sequence":"additional","affiliation":[{"name":"Anadys Pharmaceuticals, San Diego, California 92121"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Perkins","sequence":"additional","affiliation":[{"name":"Anadys Pharmaceuticals, San Diego, California 92121"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zach","family":"Little","sequence":"additional","affiliation":[{"name":"Anadys Pharmaceuticals, San Diego, California 92121"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2008,3,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2174\/156802607779318334","volume":"20","author":"Zhong S.","year":"2007","journal-title":"Curr. Topics. Med. Chem."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1021\/jm000241h","volume":"43","author":"Kuhn B.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"084108","DOI":"10.1063\/1.1999637","volume":"123","author":"Fujitani H.","year":"2005","journal-title":"J. Chem. Phys."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1021\/jm049050v","volume":"48","author":"Khandelwal A.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/ci050488t","volume":"46","author":"Brown S. P.","year":"2006","journal-title":"J. Chem. Inf. Model."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1021\/ci700041j","volume":"47","author":"Brown S. P.","year":"2007","journal-title":"J. Chem. Inf. Model."},{"key":"ref7\/cit7","first-page":"1080","volume-title":"Grid Computing - Making the Global Infrastructure a Reality","author":"Thain D.","year":"2003"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0010-4655(95)00041-D","volume":"91","author":"Pearlman D. A.","year":"1995","journal-title":"Comput. Phys. Commun."},{"key":"ref9\/cit9","unstructured":"Gobbi, A.; Lardy, M.; Showalter, R.; Zhao, Q.; Zhou, Y.Illuminator: Increasing the Impact of Computational Tools in Drug Discovery.Western Regional Meeting of the American Chemical Society, San Diego, CA, Oct 9\u201313, 2007; poster."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"S177\u2013S180","DOI":"10.1016\/S1359-6446(02)02369-3","volume":"7","author":"Chien A.","year":"2002","journal-title":"Drug Discov. Today"},{"key":"ref11\/cit11","unstructured":"Grids - A Low Cost, High Speed Alternative to Traditional High-Performance Computing.http:\/\/www.grid.org.il\/_Uploads\/dbsAttachedFiles\/GRID_ROI.pdf(accessed Jan 2008) ."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s11390-006-0513-y","volume":"21","author":"Foster I.","year":"2006","journal-title":"J. Comput. Sci. Technol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/bip.10219","volume":"68","author":"Pande V. S.","year":"2003","journal-title":"Biopolymers"},{"key":"ref14\/cit14","first-page":"839","volume":"282","year":"1998","journal-title":"Science"},{"key":"ref15\/cit15","unstructured":"The Xen virtual machine monitor.http:\/\/www.cl.cam.ac.uk\/Research\/SRG\/netos\/xen(accessed Jan 2008) ."},{"key":"ref16\/cit16","unstructured":"QEMU.http:\/\/fabrice.bellard.free.fr\/qemu(accessed Jan 2008) ."},{"key":"ref17\/cit17","unstructured":"Aloni, D.Cooperative Linux.http:\/\/www.colinux.org\/publications\/Reprint-Aloni-OLS2004.pdf(accessed Jan 2008)."},{"key":"ref18\/cit18","unstructured":"VMware.http:\/\/www.vmware.com(accessed Jan 2008)."},{"key":"ref19\/cit19","unstructured":"Parallels: Cost-effective, High-Performance Virutalization Made Easy.http:\/\/www.parallels.com\/files\/upload\/Parallels_Intel_whitepaper_on_VT_Technology.pdf(accessed Jan 2008)."},{"key":"ref20\/cit20","unstructured":"Santosa, M.; Schaefer, A.Build a heterogeneous cluster with coLinux and openMosix.http:\/\/www.ibm.com\/developerworks\/linux\/library\/l-colinux\/(accessed Jan 2008)."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1093-3263(02)00204-8","volume":"21","author":"Bostr\u00f6m J.","year":"2003","journal-title":"J. Mol. Graphics Mod."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1021\/jm040163o","volume":"48","author":"Rush T. S.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00894-002-0112-y","volume":"9","author":"Schultz-Gasch T.","year":"2003","journal-title":"J. Mol. Model."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-2836(95)80037-9","volume":"245","author":"Jones G.","year":"1995","journal-title":"J. Mol. Biol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","volume":"267","author":"Jones G.","year":"1997","journal-title":"J. Mol. Biol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/prot.10465","volume":"52","author":"Verdonk M. L.","year":"2003","journal-title":"Proteins"},{"key":"ref27\/cit27","unstructured":"OMEGA, ROCS, FRED, and SZYBKI are distributed by OpenEye Scientific Software, Santa Fe, NM:http:\/\/www.eyesopen.com(accessed Jan 2008). Gold is distributed by CCDC, Cambridge, UK:http:\/\/www.ccdc.cam.ac.uk\/products\/life_sciences\/gold\/(accessed Jan 2008)."},{"key":"ref28\/cit28","unstructured":"Beowulf.org: Overview.http:\/\/www.beowulf.org\/overview\/index.html(accessed Jan 2008)."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jcc.540141112","volume":"14","author":"Schmidt M. W.","year":"1993","journal-title":"Comput. Chem"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1145\/1242531.1242542","volume-title":"Proceedings of the 4th international conference on Computing frontiers","author":"Thorsen O.","year":"2007"},{"key":"ref31\/cit31","unstructured":"Grid Engine Project Home.http:\/\/gridengine.sunsource.net\/(accessed Jan 2008)."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.parco.2004.04.001","volume":"30","author":"Massie M. L.","year":"2004","journal-title":"Parallel Comput."},{"key":"ref33\/cit33","unstructured":"CentOS: The Community Enterprise Operating System.http:\/\/www.centos.org(accessed Jan 2008)."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1021\/ci034269o","volume":"44","author":"Gobbi A.","year":"2004","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1021\/ci050062e","volume":"45","author":"Hewitt R.","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1021\/jm050850v","volume":"49","author":"Howard N.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1021\/ci025554v","volume":"43","author":"Gobbi A.","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci700396b","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T01:02:42Z","timestamp":1678064562000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci700396b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,14]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4,1]]}},"alternative-id":["10.1021\/ci700396b"],"URL":"https:\/\/doi.org\/10.1021\/ci700396b","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,14]]}}}