{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:27:45Z","timestamp":1762997265339},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2009,8,24]]},"DOI":"10.1021\/ci900176y","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T15:13:29Z","timestamp":1248880409000},"page":"1974-1985","source":"Crossref","is-referenced-by-count":29,"title":["QSAR Models for Predicting the Similarity in Binding Profiles for Pairs of Protein Kinases and the Variation of Models between Experimental Data Sets"],"prefix":"10.1021","volume":"49","author":[{"given":"Robert P.","family":"Sheridan","sequence":"first","affiliation":[{"name":"Chemistry Modeling and Informatics Department, Merck Research Laboratories, RY50SW-100, Rahway, New Jersey 07065"}]},{"given":"Kiyean","family":"Nam","sequence":"additional","affiliation":[{"name":"Chemistry Modeling and Informatics Department, Merck Research Laboratories, RY50SW-100, Rahway, New Jersey 07065"}]},{"given":"Vladimir N.","family":"Maiorov","sequence":"additional","affiliation":[{"name":"Chemistry Modeling and Informatics Department, Merck Research Laboratories, RY50SW-100, Rahway, New Jersey 07065"}]},{"given":"Daniel R.","family":"McMasters","sequence":"additional","affiliation":[{"name":"Chemistry Modeling and Informatics Department, Merck Research Laboratories, RY50SW-100, Rahway, New Jersey 07065"}]},{"given":"Wendy D.","family":"Cornell","sequence":"additional","affiliation":[{"name":"Chemistry Modeling and Informatics Department, Merck Research Laboratories, RY50SW-100, Rahway, New Jersey 07065"}]}],"member":"316","published-online":{"date-parts":[[2009,7,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","volume":"298","author":"Manning G.","year":"2002","journal-title":"Science"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20070797","volume":"48","author":"Bain J.","year":"2007","journal-title":"Biochem. J."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"7998","DOI":"10.1021\/jm8011036","volume":"51","author":"Bamborough P.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"20523","DOI":"10.1073\/pnas.0708800104","volume":"104","author":"Federov O.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nbt1358","volume":"26","author":"Karaman M. W.","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1073\/pnas.0511292103","volume":"103","author":"Melnick J. S.","year":"2006","journal-title":"Proc. Natl. Acad. U. S. A."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"24818","DOI":"10.1074\/jbc.M512374200","volume":"281","author":"Bonn S.","year":"2006","journal-title":"Biol. Chem."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.bmcl.2006.12.086","volume":"17","author":"Cheney I. W.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2174\/0929867043455792","volume":"11","author":"Cherry M.","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science1108367","volume":"308","author":"Cohen M. S.","year":"2005","journal-title":"Science"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/anie.200503468","volume":"45","author":"Debreczeni J. E.","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"18101","DOI":"10.1073\/pnas.0608849103","volume":"103","author":"Emrick M. A.","year":"2006","journal-title":"Proc. Natl. Acad. Sci U. S. A"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nsb949","volume":"10","author":"Fitzgerald C. E.","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1021\/jm070415w","volume":"50","author":"Goldberg D. R.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.bmcl.2005.01.052","volume":"15","author":"Hamdouchi C.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1747-0285.2007.00594.x","volume":"70","author":"Kothe M.","year":"2007","journal-title":"Chem. Biol. Drug Des."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1021\/jm070077z","volume":"50","author":"Myrianthopoulos V.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1016\/j.bmcl.2005.08.077","volume":"15","author":"Pande V.","year":"2005","journal-title":"Biorg. Med. Chem. Lett."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nsmb.1486","volume":"15","author":"Azam M.","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1021\/jm049793g","volume":"47","author":"Aronov A. M.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1021\/jm701021b","volume":"51","author":"Aronov A. M.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jmgm.2005.09.004","volume":"24","author":"Sprous D. G.","year":"2006","journal-title":"J. Mol. Graph. Model."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1021\/jm701399f","volume":"51","author":"Sutherland J. J.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1021\/jm701367r","volume":"51","author":"Gozalbes R.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2174\/0929867043455684","volume":"11","author":"Muegge I.","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1021\/jm049461b","volume":"48","author":"Rockey W. M.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.chembiol.2007.10.010","volume":"14","author":"Zahler S.","year":"2007","journal-title":"Chem. Biol."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1021\/jm060190+","volume":"49","author":"Heady L.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.jmb.2005.07.074","volume":"352","author":"Sheinerman F. B.","year":"2005","journal-title":"J. Mol. Biol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/bioinformatics\/btl666","volume":"23","author":"Chen J.","year":"2007","journal-title":"Bioinformatics"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1021\/ci800289y","volume":"49","author":"Kinnings S. L.","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1021\/ci800138n","volume":"48","author":"Sciabola S.","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1021\/jm070562u","volume":"50","author":"Graczyk P. P.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nbt1068","volume":"23","author":"Fabian M. A.","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S1359-6446(05)03477-X","volume":"10","author":"Vieth M.","year":"2005","journal-title":"Drug Discovery Today"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jcc.540150503","volume":"15","author":"Abagayan R. A.","year":"1994","journal-title":"J. Comput. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1021\/ci034160g","volume":"43","author":"Svetnik V.","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1093\/nar\/18.20.6097","volume":"18","author":"Schneider T. D.","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","volume":"14","author":"Crooks G. E.","year":"2004","journal-title":"Genome Res."}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci900176y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T14:56:21Z","timestamp":1679669781000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci900176y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,29]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8,24]]}},"alternative-id":["10.1021\/ci900176y"],"URL":"https:\/\/doi.org\/10.1021\/ci900176y","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,29]]}}}