{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:41:12Z","timestamp":1772210472832,"version":"3.50.1"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2010,4,26]]},"DOI":"10.1021\/ci9004173","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T18:11:49Z","timestamp":1269972709000},"page":"615-625","source":"Crossref","is-referenced-by-count":32,"title":["Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity"],"prefix":"10.1021","volume":"50","author":[{"given":"Zhi","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People\u2019s Republic of China, and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}]},{"given":"Guanghui","family":"Tian","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People\u2019s Republic of China, and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People\u2019s Republic of China, and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}]},{"given":"Hualiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People\u2019s Republic of China, and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}]},{"given":"Jingshan","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People\u2019s Republic of China, and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}]},{"given":"Weiliang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People\u2019s Republic of China, and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}]}],"member":"316","published-online":{"date-parts":[[2010,3,30]]},"reference":[{"issue":"7","key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.drudis.2006.02.008","volume":"11","author":"Stahl M.","year":"2006","journal-title":"Drug Discovery Today"},{"issue":"9","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2174\/0929867013372481","volume":"8","author":"Kurogi Y.","year":"2001","journal-title":"Curr. Med. Chem."},{"issue":"22","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.2174\/0929867043364036","volume":"11","author":"Guner O.","year":"2004","journal-title":"Curr. Med. Chem."},{"issue":"12","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s10822-006-9066-y","volume":"20","author":"Steindl T. M.","year":"2006","journal-title":"J. Comput.-Aided Mol. Des"},{"issue":"1","key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1021\/ci049885e","volume":"45","author":"Wolber G.","year":"2005","journal-title":"J. Chem. Inf. Model."},{"issue":"3","key":"ref6\/cit6","first-page":"370","volume":"6","author":"Langer T.","year":"2003","journal-title":"Curr. Opin. Drug Discovery Devel."},{"issue":"1","key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/ci049778k","volume":"45","author":"Krovat E. M.","year":"2005","journal-title":"J. Chem. Inf. Model."},{"issue":"11","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1007\/s00018-005-4533-5","volume":"62","author":"Jeon Y. H.","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"issue":"5472","key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1126\/science.288.5472.1822","volume":"288","author":"Xu R. X.","year":"2000","journal-title":"Science"},{"issue":"3","key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1210\/edrv-12-3-218","volume":"12","author":"Conti M.","year":"1991","journal-title":"Endocr. Rev."},{"issue":"5","key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0165-6147(97)01049-3","volume":"18","author":"Teixeira M. M.","year":"1997","journal-title":"Trends Pharmacol. Sci."},{"issue":"3","key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/bjp.2008.307","volume":"155","author":"Spina D.","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"9485","key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0140-6736(05)67100-0","volume":"366","author":"Rabe K. F.","year":"2005","journal-title":"Lancet"},{"issue":"2","key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1164\/rccm.200610-1563OC","volume":"176","author":"Calverley P. M.","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med"},{"issue":"1","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1378\/chest.129.1.56","volume":"129","author":"Rennard S. I.","year":"2006","journal-title":"Chest"},{"issue":"11","key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1021\/jm050063y","volume":"48","author":"Krier M.","year":"2005","journal-title":"J. Med. Chem."},{"issue":"8","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1021\/ci800072r","volume":"48","author":"Rizzi A.","year":"2008","journal-title":"J. Chem. Inf. Model."},{"issue":"9","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1023\/A:1013104713913","volume":"15","author":"Ducrot P.","year":"2001","journal-title":"J. Comput.-Aided Mol. Des"},{"issue":"1","key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-2836(95)80037-9","volume":"245","author":"Jones G.","year":"1995","journal-title":"J. Mol. Biol."},{"issue":"3","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","volume":"267","author":"Jones G.","year":"1997","journal-title":"J. Mol. Biol."},{"issue":"4","key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/prot.10465","volume":"52","author":"Verdonk M. L.","year":"2003","journal-title":"Proteins"},{"issue":"7","key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","volume":"47","author":"Friesner R. A.","year":"2004","journal-title":"J. Med. Chem."},{"issue":"21","key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","volume":"49","author":"Friesner R. A.","year":"2006","journal-title":"J. Med. Chem."},{"issue":"1","key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman H. M.","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1021\/jm010458r","volume":"45","author":"Palomer A.","year":"2002","journal-title":"J. Med. Chem."},{"issue":"6","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1023\/A:1008191129541","volume":"14","author":"Norinder U.","year":"2000","journal-title":"J. Comput.-Aided Mol. Des."},{"issue":"14","key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1021\/jm9708691","volume":"41","author":"Greenidge P. A.","year":"1998","journal-title":"J. Med. Chem."},{"issue":"23","key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1021\/jm0608356","volume":"49","author":"Huang N.","year":"2006","journal-title":"J. Med. Chem."},{"issue":"11","key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1517\/13543770903313753","volume":"19","author":"Pages L.","year":"2009","journal-title":"Expert Opin. Ther. Pat."},{"issue":"2","key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jmb.2004.01.040","volume":"337","author":"Xu R. X.","year":"2004","journal-title":"J. Mol. Biol."},{"issue":"6","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1021\/jm051273d","volume":"49","author":"Huai Q.","year":"2006","journal-title":"J. Med. Chem."},{"issue":"17","key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/S0960-894X(02)00401-8","volume":"12","author":"Shin H. J.","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"12","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.str.2004.10.004","volume":"12","author":"Card G. L.","year":"2004","journal-title":"Structure"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1021\/ci970437z","volume":"38","author":"Flower D. R.","year":"1998","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/ci9800211","volume":"38","author":"Willett P.","year":"1998","journal-title":"J. Chem. Inf. Comput. Sci."}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci9004173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T05:09:30Z","timestamp":1679461770000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci9004173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,30]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4,26]]}},"alternative-id":["10.1021\/ci9004173"],"URL":"https:\/\/doi.org\/10.1021\/ci9004173","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,30]]}}}