{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T20:54:41Z","timestamp":1768078481703,"version":"3.49.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2010,3,22]]},"DOI":"10.1021\/ci9004805","type":"journal-article","created":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T17:25:38Z","timestamp":1267550738000},"page":"446-460","source":"Crossref","is-referenced-by-count":9,"title":["Receptor- and Ligand-Based Study on Novel 2,2\u2032-Bithienyl Derivatives as Non-Peptidic AANAT Inhibitors"],"prefix":"10.1021","volume":"50","author":[{"given":"Alban","family":"Lepailleur","sequence":"first","affiliation":[{"name":"Centre d\u2019Etudes et de Recherche sur le M\u00e9dicament de Normandie, UPRES EA 4258, INC3M FR CNRS 3038, Universit\u00e9 de Caen\u2212Basse Normandie, UFR des Sciences Pharmaceutiques, Boulevard Becquerel, 14032 Caen Cedex, France, and Laboratoires Servier, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Lema\u00eetre","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes et de Recherche sur le M\u00e9dicament de Normandie, UPRES EA 4258, INC3M FR CNRS 3038, Universit\u00e9 de Caen\u2212Basse Normandie, UFR des Sciences Pharmaceutiques, Boulevard Becquerel, 14032 Caen Cedex, France, and Laboratoires Servier, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Feng","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes et de Recherche sur le M\u00e9dicament de Normandie, UPRES EA 4258, INC3M FR CNRS 3038, Universit\u00e9 de Caen\u2212Basse Normandie, UFR des Sciences Pharmaceutiques, Boulevard Becquerel, 14032 Caen Cedex, France, and Laboratoires Servier, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Sopkova-de Oliveira Santos","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes et de Recherche sur le M\u00e9dicament de Normandie, UPRES EA 4258, INC3M FR CNRS 3038, Universit\u00e9 de Caen\u2212Basse Normandie, UFR des Sciences Pharmaceutiques, Boulevard Becquerel, 14032 Caen Cedex, France, and Laboratoires Servier, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Delagrange","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes et de Recherche sur le M\u00e9dicament de Normandie, UPRES EA 4258, INC3M FR CNRS 3038, Universit\u00e9 de Caen\u2212Basse Normandie, UFR des Sciences Pharmaceutiques, Boulevard Becquerel, 14032 Caen Cedex, France, and Laboratoires Servier, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Boutin","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes et de Recherche sur le M\u00e9dicament de Normandie, UPRES EA 4258, INC3M FR CNRS 3038, Universit\u00e9 de Caen\u2212Basse Normandie, UFR des Sciences Pharmaceutiques, Boulevard Becquerel, 14032 Caen Cedex, France, and Laboratoires Servier, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Renard","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes et de Recherche sur le M\u00e9dicament de Normandie, UPRES EA 4258, INC3M FR CNRS 3038, Universit\u00e9 de Caen\u2212Basse Normandie, UFR des Sciences Pharmaceutiques, Boulevard Becquerel, 14032 Caen Cedex, France, and Laboratoires Servier, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronan","family":"Bureau","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes et de Recherche sur le M\u00e9dicament de Normandie, UPRES EA 4258, INC3M FR CNRS 3038, Universit\u00e9 de Caen\u2212Basse Normandie, UFR des Sciences Pharmaceutiques, Boulevard Becquerel, 14032 Caen Cedex, France, and Laboratoires Servier, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Rault","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes et de Recherche sur le M\u00e9dicament de Normandie, UPRES EA 4258, INC3M FR CNRS 3038, Universit\u00e9 de Caen\u2212Basse Normandie, UFR des Sciences Pharmaceutiques, Boulevard Becquerel, 14032 Caen Cedex, France, and Laboratoires Servier, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2010,3,2]]},"reference":[{"key":"ref1\/cit1","volume-title":"Melatonin and the Mammalian Pineal Gland","author":"Arendt J.","year":"1995"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-58932-4_1","volume":"146","author":"Korf H. W.","year":"1998","journal-title":"Adv. Anat., Embryol. Cell. Biol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.preteyeres.2005.01.003","volume":"24","author":"Iuvone P. M.","year":"2005","journal-title":"Prog. Ret. Eye Res."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1006\/exer.2000.0973","volume":"72","author":"Djeridane Y.","year":"2001","journal-title":"Exp. Eye Res."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1023\/A:1020107915919","volume":"47","author":"Bubenik G. A.","year":"2002","journal-title":"Dig. Dis. Sci."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1034\/j.1600-079X.2000.280401.x","volume":"28","author":"Conti A.","year":"2000","journal-title":"J. Pineal Res."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tem.2007.10.007","volume":"19","author":"Slominski A.","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"key":"ref8\/cit8","first-page":"199","volume-title":"The pineal Gland V 1","author":"Klein D. C.","year":"1981"},{"key":"ref9\/cit9","first-page":"45","volume-title":"Handbook of Behavioral State control: Cellular and Molecular Mechanisms","author":"Klein D. C.","year":"1999"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.184.4144.1341","volume":"184","author":"Axelrod J.","year":"1974","journal-title":"Science"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1210\/edrv-12-2-151","volume":"12","author":"Reiter R. J.","year":"1991","journal-title":"Endocr. Rev."},{"key":"ref12\/cit12","first-page":"307","volume":"52","author":"Klein D. C.","year":"1997","journal-title":"Recent Prog. Horm. Res."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/157488907782411756","volume":"2","author":"Mody S. M.","year":"2007","journal-title":"Recent Pat. CNS Drug Discov."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ardp.200400996","volume":"338","author":"Zlotos D. P.","year":"2005","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"ref15\/cit15","volume-title":"The Melatonin Miracle. Nature\u2019s Age-Reversing, Disease-Fighting, Sex-Enhancing Hormone","author":"Pierpaoli W.","year":"1995"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0092-8674(95)90131-0","volume":"83","author":"Reppert S. M.","year":"1995","journal-title":"Cell"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1126\/science.3798117","volume":"235","author":"Lewy A. J.","year":"1987","journal-title":"Science"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/00004714-199812000-00005","volume":"18","author":"Bonhomme N.","year":"1998","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.2174\/0929867023370013","volume":"9","author":"Zheng W.","year":"2002","journal-title":"Curr. Med. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0014-2999(96)00228-2","volume":"307","author":"Shen S.","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"8794","DOI":"10.1074\/jbc.275.12.8794","volume":"275","author":"Ferry G.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref22\/cit22","first-page":"61","volume-title":"Comprehensive Medicinal Chemistry","volume":"2","author":"Page A. I.","year":"1990"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"6195","DOI":"10.1021\/ja981365a","volume":"120","author":"Khalil E. M.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"12418","DOI":"10.1073\/pnas.96.22.12418","volume":"96","author":"Khalil E. M.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1021\/jm010049v","volume":"44","author":"Kim C. M.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1074-5521(01)00020-5","volume":"8","author":"Zheng W.","year":"2001","journal-title":"Chem. Biol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1046\/j.1432-1033.2003.03942.x","volume":"271","author":"Ferry G.","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/1475636021000005721","volume":"17","author":"Beaurain N.","year":"2002","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1021\/jm0706463","volume":"50","author":"Szewczuk L. M.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","volume":"47","author":"Friesner R. A.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0092-8674(00)80745-X","volume":"97","author":"Hickman A. B.","year":"1999","journal-title":"Cell"},{"key":"ref32\/cit32a","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1021\/ja00226a005","volume":"110","author":"Cramer R. D.","year":"1988","journal-title":"J. Am. Chem. Soc."},{"key":"ref32\/cit32b","first-page":"443","volume-title":"3D QSAR in Drug Design: Recent Advances","author":"Cramer R. D.,","year":"1993"},{"key":"ref32\/cit32c","first-page":"161","volume":"291","author":"Cramer R. D.","year":"1989","journal-title":"Prog. Clin. Biol. Res."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1107\/S0108768102003890","volume":"58","author":"Allen F. H.","year":"2002","journal-title":"Acta Crystallogr."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/qsar.19930120205","volume":"12","author":"Clark M.","year":"1993","journal-title":"Quant. Struct.-Act. Relat."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1021\/ci049944o","volume":"44","author":"Melville J. L.","year":"2004","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1021\/jm00050a010","volume":"37","author":"Klebe G.","year":"1994","journal-title":"J. Med. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1016\/0040-4020(95)00111-K","volume":"51","author":"Albers W. M.","year":"1995","journal-title":"Tetrahedron"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"6906","DOI":"10.1021\/jo960897b","volume":"61","author":"Wu R.","year":"1996","journal-title":"J. Org. Chem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1021\/jm9507136","volume":"39","author":"Vallgarda J.","year":"1996","journal-title":"J. Med. Chem."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"9640","DOI":"10.1021\/jo9912653","volume":"64","author":"Van den Hoven B. G.","year":"1999","journal-title":"J. Org. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1016\/S0040-4020(99)00121-0","volume":"14","author":"Zheng A.","year":"1999","journal-title":"Tetrahedron"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00018-002-8517-4","volume":"59","author":"Ferry G.","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"8794","DOI":"10.1074\/jbc.275.12.8794","volume":"275","author":"Ferry G.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Bradford M. M.","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00210-003-0751-2","volume":"367","author":"Audinot V.","year":"2003","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref46\/cit46","unstructured":"Petricek, V.; Dusek, M.JANA98; The Crystallographic Computing System;Institute of Physics: Praha, Czech Republic, 1998."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1107\/S0108767390000277","volume":"46","author":"Sheldrick G. M.","year":"1990","journal-title":"Acta Crystallogr."},{"key":"ref47\/cit47a","unstructured":"(b)Sheldrick, G. M.SHELX-97; Program for the Refinement of Crystal Structures;University of G\u00f6ttingen:G\u00f6ttingen, Germany, 1997."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman H. M.","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref49\/cit49","volume-title":"Sybyl 6.9","year":"2003"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jcc.540100804","volume":"10","author":"Clark M.","year":"1989","journal-title":"J. Comput. Chem."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF01593790","volume":"12","author":"Powell M. J. D.","year":"1977","journal-title":"Math. Program."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/BF00124364","volume":"7","author":"Bush B. L.","year":"1993","journal-title":"J. Comput.-Aided Mol. Des"},{"key":"ref53\/cit53","first-page":"717","volume-title":"3D-QSAR in Drug Design-Theory, Methods and Applications","author":"Kubinyi H.","year":"1993"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci9004805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T12:01:25Z","timestamp":1679659285000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci9004805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,2]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3,22]]}},"alternative-id":["10.1021\/ci9004805"],"URL":"https:\/\/doi.org\/10.1021\/ci9004805","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,2]]}}}