{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:45:43Z","timestamp":1768463143311,"version":"3.49.0"},"reference-count":27,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Comput. Sci."],"published-print":{"date-parts":[[2000,1,1]]},"DOI":"10.1021\/ci990427t","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:58:18Z","timestamp":1027663098000},"page":"71-80","source":"Crossref","is-referenced-by-count":143,"title":["Estimation of Molecular Linear Free Energy Relationship Descriptors by a Group Contribution Approach. 2. Prediction of Partition Coefficients"],"prefix":"10.1021","volume":"40","author":[{"given":"James A.","family":"Platts","sequence":"first","affiliation":[{"name":"Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K., and Science Development Group, Glaxo Wellcome Research and Development, Park Road, Ware SG12 0DP, U.K."}]},{"given":"Michael H.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K., and Science Development Group, Glaxo Wellcome Research and Development, Park Road, Ware SG12 0DP, U.K."}]},{"given":"Darko","family":"Butina","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K., and Science Development Group, Glaxo Wellcome Research and Development, Park Road, Ware SG12 0DP, U.K."}]},{"given":"Anne","family":"Hersey","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K., and Science Development Group, Glaxo Wellcome Research and Development, Park Road, Ware SG12 0DP, U.K."}]}],"member":"316","published-online":{"date-parts":[[1999,11,19]]},"reference":[{"key":"ci990427tb00001\/ci990427tb00001_1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1021\/ci980339t","volume":"39","author":"Platts J. A.","year":"1999","journal-title":"J. Chem Inf. Comput. Sci."},{"key":"ci990427tb00002\/ci990427tb00002_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1039\/cs9932200073","volume":"22","author":"Abraham M. H","year":"1993","journal-title":"Chem. Soc. Rev."},{"key":"ci990427tb00003\/ci990427tb00003_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF02311772","volume":"23","author":"Abraham M. H.","year":"1987","journal-title":"Chromatographia"},{"key":"ci990427tb00004\/ci990427tb00004_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0021-9673(91)85158-C","volume":"587","author":"Abraham M. H.","year":"1991","journal-title":"J. Chromatogr."},{"key":"ci990427tb00005\/ci990427tb00005_1","first-page":"1268","volume":"83","author":"Abraham M. H.","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"ci990427tb00005\/ci990427tb00005_2","first-page":"1100","volume":"83","author":"Abraham M. H.","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"ci990427tb00005\/ci990427tb00005_3","volume-title":"Lipophilicity in Drug Action and Toxicology","author":"Abraham M. H.","year":"1996"},{"key":"ci990427tb00006\/ci990427tb00006_1","first-page":"147","volume":"20","year":"1993","journal-title":"Acc. Chem. Res."},{"key":"ci990427tb00007\/ci990427tb00007_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1021\/js990008a","volume":"88","author":"Abraham M. H.","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"ci990427tb00008\/ci990427tb00008_1","first-page":"722","volume":"705","author":"Leahy D. E.","year":"1992","journal-title":"J. Chem. Soc., Perkin Trans. 2"},{"key":"ci990427tb00009\/ci990427tb00009_1","volume-title":"The Hydrophobic Fragmental Constant","author":"Rekker R. F.","year":"1977"},{"key":"ci990427tb00010\/ci990427tb00010_1","first-page":"1306","volume":"93","author":"Leo A. J.","year":"1993","journal-title":"Chem. Rev."},{"key":"ci990427tb00011\/ci990427tb00011_1","first-page":"781","volume":"34","author":"Klopman G.","year":"1994","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci990427tb00012\/ci990427tb00012_1","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1021\/jp980230o","volume":"102","author":"Ghose A. K.","year":"1998","journal-title":"J. Phys. Chem. A"},{"key":"ci990427tb00012\/ci990427tb00012_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jcc.540070419","volume":"7","author":"Ghose A. K.","year":"1986","journal-title":"J. Comput. Chem."},{"key":"ci990427tb00013\/ci990427tb00013_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1021\/ci00009a013","volume":"32","author":"Klopman G.","year":"1992","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ci990427tb00014\/ci990427tb00014_1","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1021\/jo980046z","volume":"63","author":"Hawkins G. D.","year":"1998","journal-title":"J. Org. Chem."},{"key":"ci990427tb00015\/ci990427tb00015_1","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1021\/ja00172a038","volume":"112","author":"Still W. C.","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"ci990427tb00016\/ci990427tb00016_1","first-page":"381","volume":"13","author":"Collander R.","year":"1947","journal-title":"Acta Physiol. Scand."},{"key":"ci990427tb00017\/ci990427tb00017_1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2174\/0929867305666220319102516","volume":"5","author":"Buchwald P.","year":"1998","journal-title":"Curr. Med. Chem."},{"key":"ci990427tb00018\/ci990427tb00018_1","first-page":"18","volume":"4","author":"Sch\u00fc\u00fcrman G.","year":"1995","journal-title":"Fresenius Environ. Bull."},{"key":"ci990427tb00019\/ci990427tb00019_1","volume-title":"Masterfile 1997 from MedChem software","author":"Leo A. J."},{"key":"ci990427tb00020\/ci990427tb00020_1","volume-title":"Biobyte Corp, P.O. Box 517","author":"Clog"},{"key":"ci990427tb00021\/ci990427tb00021_1","first-page":"814","volume":"74","author":"Taft R. W.","year":"1985","journal-title":"J. Pharm. Sci."},{"key":"ci990427tb00021\/ci990427tb00021_2","first-page":"598","volume":"80","author":"Leahy D. E","year":"1991","journal-title":"J. Pharm. Sci."},{"key":"ci990427tb00021\/ci990427tb00021_3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1039\/a606374h","volume":"93","author":"Steyaert G.","year":"1997","journal-title":"J. Chem. Soc., Faraday Trans."},{"key":"ci990427tb00022\/ci990427tb00022_1","first-page":"880","volume":"89","author":"Le J.","year":"1999","journal-title":"J. Pharm. Sci."}],"container-title":["Journal of Chemical Information and Computer Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ci990427t","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T10:28:05Z","timestamp":1681986485000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ci990427t"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11,19]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1,1]]}},"alternative-id":["10.1021\/ci990427t"],"URL":"https:\/\/doi.org\/10.1021\/ci990427t","relation":{},"ISSN":["0095-2338"],"issn-type":[{"value":"0095-2338","type":"print"}],"subject":[],"published":{"date-parts":[[1999,11,19]]}}}