{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:36:08Z","timestamp":1790472968833,"version":"4.1.0"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2001,4,1]]},"DOI":"10.1021\/ac0100650","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:56:38Z","timestamp":1027659398000},"page":"1651-1657","source":"Crossref","is-referenced-by-count":49,"title":["Direct Profiling of Multiple Enzyme Activities in Human Cell Lysates by Affinity Chromatography\/Electrospray Ionization Mass Spectrometry:\u2009 Application to Clinical Enzymology"],"prefix":"10.1021","volume":"73","author":[{"given":"Scott A.","family":"Gerber","sequence":"first","affiliation":[{"name":"Departments of Chemistry, Pediatrics, and Biochemistry, University of Washington, Seattle, Washington 98195-1700"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Ronald","family":"Scott","sequence":"additional","affiliation":[{"name":"Departments of Chemistry, Pediatrics, and Biochemistry, University of Washington, Seattle, Washington 98195-1700"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franti\u0161ek","family":"Ture\u010dek","sequence":"additional","affiliation":[{"name":"Departments of Chemistry, Pediatrics, and Biochemistry, University of Washington, Seattle, Washington 98195-1700"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Gelb","sequence":"additional","affiliation":[{"name":"Departments of Chemistry, Pediatrics, and Biochemistry, University of Washington, Seattle, Washington 98195-1700"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2001,3,14]]},"reference":[{"key":"ac0100650b00001\/ac0100650b00001_1","volume-title":"The metabolic and molecular bases of inherited disease","author":"Scriver C. R.","year":"1995"},{"key":"ac0100650b00002\/ac0100650b00002_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1651-2227.1999.tb01160.x","volume":"88","author":"McCabe E. R.","year":"1999","journal-title":"Acta Paediatr. Suppl."},{"key":"ac0100650b00003\/ac0100650b00003_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/75452","volume":"18","author":"Favis R.","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"ac0100650b00004\/ac0100650b00004_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1089\/gte.1997.1.5","volume":"1","author":"Grabowski G. A.","year":"1997","journal-title":"Genet. Test."},{"key":"ac0100650b00005\/ac0100650b00005_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/humu.1380010303","volume":"1","author":"Reichardt J. K.","year":"1992","journal-title":"Hum. Mutat."},{"key":"ac0100650b00006\/ac0100650b00006_1","volume-title":"e. Clinical laboratory medicine","author":"McClatchey K. D.","year":"1994"},{"key":"ac0100650b00007\/ac0100650b00007_1","volume-title":"Techniques in diagnostic human biochemical genetics:\u2009 a laboratory manual","author":"Hommes F. A.","year":"1991"},{"key":"ac0100650b00008\/ac0100650b00008_1","first-page":"1103","volume":"121","author":"Gerber S. A.","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"ac0100650b00009\/ac0100650b00009_1","doi-asserted-by":"crossref","first-page":"11297","DOI":"10.1073\/pnas.91.24.11290","volume":"91","author":"Siuzdak G.","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ac0100650b00010\/ac0100650b00010_1","first-page":"257","volume":"68","author":"Roe C. R.","year":"1999","journal-title":"Mol. Genet. Metab."},{"key":"ac0100650b00011\/ac0100650b00011_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0958-1669(99)80005-6","volume":"10","author":"Costello C. E.","year":"1999","journal-title":"Curr. Opin. Biotechnol."},{"key":"ac0100650b00012\/ac0100650b00012_1","first-page":"671","volume":"184","author":"Wilchek M.","year":"1990","journal-title":"Methods Enzymol."},{"key":"ac0100650b00013\/ac0100650b00013_1","first-page":"584","volume":"8","author":"Wilbur D. S.","year":"1997","journal-title":"Bioconjugate Chem."},{"key":"ac0100650b00014\/ac0100650b00014_1","first-page":"583","volume":"11","author":"Wilbur D. S.","year":"2000","journal-title":"Bioconjugate Chem."},{"key":"ac0100650b00015\/ac0100650b00015_1","volume-title":"The metabolic and molecular bases of inherited disease","author":"Neufeld E. F.","year":"1995"},{"key":"ac0100650b00016\/ac0100650b00016_1","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1089\/hum.1996.7.16-1965","volume":"7","author":"Bielicki J.","year":"1996","journal-title":"Hum. Gene Ther."},{"key":"ac0100650b00017\/ac0100650b00017_1","first-page":"963","volume":"15","author":"Dean M. F.","year":"1981","journal-title":"Pediatr. Res."},{"key":"ac0100650b00018\/ac0100650b00018_1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1126\/science.1589760","volume":"256","author":"Beutler E.","year":"1992","journal-title":"Science"},{"key":"ac0100650b00019\/ac0100650b00019_1","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1056\/NEJM199105233242104","volume":"324","author":"Barton N. W.","year":"1991","journal-title":"Engl. J. Med."},{"key":"ac0100650b00020\/ac0100650b00020_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1073\/pnas.97.1.365","volume":"97","author":"Schiffmann R.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ac0100650b00021\/ac0100650b00021_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1146\/annurev.biochem.68.1.729","volume":"68","author":"Bernfield M.","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"ac0100650b00022\/ac0100650b00022_1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/0006-291X(73)90807-3","volume":"54","author":"Kresse H.","year":"1973","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ac0100650b00023\/ac0100650b00023_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1073\/pnas.69.7.1720","volume":"69","author":"O'Brien J. S.","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ac0100650b00024\/ac0100650b00024_1","first-page":"5189","volume":"75","author":"Klein U.","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ac0100650b00025\/ac0100650b00025_1","doi-asserted-by":"crossref","first-page":"6826","DOI":"10.1073\/pnas.77.11.6822","volume":"77","author":"Kresse H.","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ac0100650b00026\/ac0100650b00026_1","volume-title":"The AGT cytogenetics laboratory manual","year":"1997","edition":"3"},{"key":"ac0100650b00027\/ac0100650b00027_1","first-page":"572","volume":"83","author":"Kresse H.","year":"1982","journal-title":"Methods Enzymol."},{"key":"ac0100650b00028\/ac0100650b00028_1","first-page":"941","volume":"16","author":"He W.","year":"1993","journal-title":"J. Inherit. Metab. Dis."},{"key":"ac0100650b00029\/ac0100650b00029_1","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1016\/S0021-9258(18)32199-9","volume":"258","author":"Reynertson R.","year":"1983","journal-title":"J. Biol. Chem."},{"key":"ac0100650b00030\/ac0100650b00030_1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1203\/00006450-198911000-00020","volume":"26","author":"Nowakowski R. W.","year":"1989","journal-title":"Pediatr. Res."},{"key":"ac0100650b00031\/ac0100650b00031_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1399-0004.1985.tb00217.x","volume":"27","author":"Marsh J.","year":"1985","journal-title":"Clin. Genet."},{"key":"ac0100650b00032\/ac0100650b00032_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01799255","volume":"19","author":"Karpova E. A.","year":"1996","journal-title":"J. Inherit. Metab. Dis."},{"key":"ac0100650b00033\/ac0100650b00033_1","first-page":"472","volume":"16","author":"Voznyi Ya V.","year":"1993","journal-title":"J. Inherit. Metab. Dis."}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ac0100650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T20:39:46Z","timestamp":1704227986000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ac0100650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,14]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,4,1]]}},"alternative-id":["10.1021\/ac0100650"],"URL":"https:\/\/doi.org\/10.1021\/ac0100650","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,14]]}}}