{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:36:19Z","timestamp":1791070579733,"version":"4.1.0"},"reference-count":21,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2012,6,19]]},"DOI":"10.1021\/ac3008847","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T02:23:23Z","timestamp":1337826203000},"page":"5380-5386","source":"Crossref","is-referenced-by-count":49,"title":["Charge Heterogeneity of Monoclonal Antibodies by Multiplexed Imaged Capillary Isoelectric Focusing Immunoassay with Chemiluminescence Detection"],"prefix":"10.1021","volume":"84","author":[{"given":"David A.","family":"Michels","sequence":"first","affiliation":[{"name":"Department of Protein\rAnalytical\rChemistry, Genentech, a Member of the Roche\rGroup, 1 DNA Way, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea W.","family":"Tu","sequence":"additional","affiliation":[{"name":"ProteinSimple, 3040 Oakmead Village Drive, Santa Clara, California 95051, United\rStates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will","family":"McElroy","sequence":"additional","affiliation":[{"name":"Department of Protein\rAnalytical\rChemistry, Genentech, a Member of the Roche\rGroup, 1 DNA Way, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Voehringer","sequence":"additional","affiliation":[{"name":"ProteinSimple, 3040 Oakmead Village Drive, Santa Clara, California 95051, United\rStates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Salas-Solano","sequence":"additional","affiliation":[{"name":"Department of Analytical\rBiochemistry, Seattle Genetics, Inc., 21823\r30th Drive SE, Bothell,\rWashington 98021, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2012,6,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4161\/mabs.2.6.13333","volume":"2","author":"Khawli L. A.","year":"2010","journal-title":"mAbs"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1002\/elps.1150191307","volume":"19","author":"Fang X.","year":"1998","journal-title":"Electrophoresis"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1002\/elps.200290005","volume":"23","author":"Shimura K.","year":"2002","journal-title":"Electrophoresis"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1021\/ac902408r","volume":"82","author":"Meert C. D.","year":"2010","journal-title":"Anal. Chem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ab.2010.11.040","volume":"410","author":"Zhang J.","year":"2011","journal-title":"Anal. Biochem."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1002\/elps.200800157","volume":"29","author":"Sosic Z.","year":"2008","journal-title":"Electrophoresis"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"16153","DOI":"10.1073\/pnas.0607973103","volume":"103","author":"O\u2019Neill R. A.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"9478","DOI":"10.1021\/ac071537z","volume":"79","author":"Knittle J. E.","year":"2007","journal-title":"Anal. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0167-7799(99)01402-X","volume":"18","author":"Dorman G.","year":"2000","journal-title":"Trends Biotechnol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"6643","DOI":"10.1021\/ac049212v","volume":"76","author":"Janecki D. J.","year":"2004","journal-title":"Anal. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/pmic.200500225","volume":"6","author":"Krawitz D. C.","year":"2006","journal-title":"Proteomics"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0021-9673(94)01255-D","volume":"705","author":"Harris R. J.","year":"1995","journal-title":"J. Chromatogr. A"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/1522-2683(200202)23:4<542::AID-ELPS542>3.0.CO;2-B","volume":"23","author":"Wu X.-Z.","year":"2002","journal-title":"Electrophoresis"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0021-9673(98)00326-4","volume":"817","author":"Wu J.","year":"1998","journal-title":"J. Chromatogr. A"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1177\/22.12.1084","volume":"22","author":"Nakane P. K.","year":"1974","journal-title":"J. Histochem. Cytochem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0021-9673(97)01134-5","volume":"800","author":"Hunt G.","year":"1998","journal-title":"J. Chromatogr. A"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0021-9673(96)00437-2","volume":"744","author":"Hunt G.","year":"1996","journal-title":"J. Chromatogr. A"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jpba.2006.09.024","volume":"43","author":"Li N.","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1021\/ac8025948","volume":"81","author":"Ramsay L. M.","year":"2009","journal-title":"Anal. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/elps.200800498","volume":"30","author":"Ramsay L. M.","year":"2009","journal-title":"Electrophoresis"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/abio.2000.5006","volume":"291","author":"Billinton N.","year":"2001","journal-title":"Anal. Biochem."}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ac3008847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T01:34:05Z","timestamp":1680572045000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ac3008847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,5]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,6,19]]}},"alternative-id":["10.1021\/ac3008847"],"URL":"https:\/\/doi.org\/10.1021\/ac3008847","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,5]]}}}