{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:31:47Z","timestamp":1791221507085,"version":"4.1.0"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2012,11,6]]},"DOI":"10.1021\/ac301853q","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T16:27:52Z","timestamp":1346862472000},"page":"8909-8916","source":"Crossref","is-referenced-by-count":91,"title":["Time-of-Flight Secondary Ion Mass Spectrometry-Based Molecular Distribution Distinguishing Healthy and Osteoarthritic Human Cartilage"],"prefix":"10.1021","volume":"84","author":[{"given":"Berta","family":"Cillero-Pastor","sequence":"first","affiliation":[{"name":"Biomolecular Imaging Mass Spectrometry (BIMS), FOM Institute AMOLF, Amsterdam, The Netherlands"},{"name":"Rheumatology Division, Proteomic\rUnit, Proteo-Red-ISCIII, INIBIC-Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Eijkel","sequence":"additional","affiliation":[{"name":"Biomolecular Imaging Mass Spectrometry (BIMS), FOM Institute AMOLF, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Kiss","sequence":"additional","affiliation":[{"name":"Biomolecular Imaging Mass Spectrometry (BIMS), FOM Institute AMOLF, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Proteomic\rUnit, Proteo-Red-ISCIII, INIBIC-Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron M. A.","family":"Heeren","sequence":"additional","affiliation":[{"name":"Biomolecular Imaging Mass Spectrometry (BIMS), FOM Institute AMOLF, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2012,10,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.joca.2003.10.002","volume":"12","author":"Martel-Pelletier J.","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.berh.2008.02.001","volume":"22","author":"Martel-Pelletier J","year":"2008","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref3\/cit3","first-page":"S236","volume":"15","author":"Altman R. D.","year":"2009","journal-title":"Am. J. Managed Care"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/ard.2010.138230","volume":"70","author":"Bijsterbosch J","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0140-6736(00)04264-1","volume":"357","author":"Aspden R. M.","year":"2001","journal-title":"Lancet"},{"key":"ref6\/cit6","first-page":"347","volume":"27","author":"Masuko K","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/BOR.0b013e32831bc0d7","volume":"21","author":"Anandacoomarasamy A","year":"2009","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref8\/cit8","unstructured":"Bonet, M. L.; Granados, N; Palou, A.Molecular Players at the Intersection of Obesity and Osteoarthritis.Curr. Drug Targets 2011, not supplied."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/ncb0903-769","volume":"5","author":"Zhang K","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/joca.1998.0220","volume":"7","author":"Lotz M","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nrrheum.2012.11","volume":"8","author":"Blanco F. J.","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1749-799X-2-14","volume":"2","author":"Chen Y","year":"2007","journal-title":"J. Orthop. Surg. Res."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0736-0266(00)00064-4","volume":"19","author":"Sarma A. V.","year":"2001","journal-title":"J. Orthop. Res."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1021\/cr100012c","volume":"110","author":"Chughtai K","year":"2010","journal-title":"Chem. Rev."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/mas.20124","volume":"26","author":"McDonnell L. A.","year":"2007","journal-title":"Mass Spectrom. Rev."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0248-4900(92)90004-K","volume":"74","author":"Fragu P","year":"1992","journal-title":"Biol. Cell"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-60761-746-4_11","volume":"656","author":"Altelaar A. F.","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1016\/j.chroma.2010.01.033","volume":"1217","author":"Amstalden van Hove E. R.","year":"2010","journal-title":"J. Chromatogr., A"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1021\/ac0513111","volume":"78","author":"Altelaar A. F.","year":"2006","journal-title":"Anal. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1039\/b913575h","volume":"134","author":"Fletcher J. S.","year":"2009","journal-title":"Analyst"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/jemt.20502","volume":"70","author":"Nygren H","year":"2007","journal-title":"Microsc. Res. Tech."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1183\/09031936.00195610","volume":"39","author":"Almstrand A. C.","year":"2012","journal-title":"Eur. Respir. J."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1194\/jlr.M700421-JLR200","volume":"49","author":"Tahallah N","year":"2008","journal-title":"J. Lipid Res."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1007\/s00216-010-4155-0","volume":"399","author":"Malmberg P","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1159\/000187563","volume":"65","author":"Chaussidon M.","year":"1993","journal-title":"Nephron"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1021\/ac100837n","volume":"82","author":"Klerk L. A.","year":"2010","journal-title":"Anal. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/rcm.4183","volume":"23","author":"Heim C","year":"2009","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","volume":"6","author":"Sellam J.","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.2337\/db09-0848","volume":"59","author":"Mas S.","year":"2010","journal-title":"Diabetes"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1038\/oby.2008.424","volume":"16","author":"Magnusson Y. K.","year":"2008","journal-title":"Obesity"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1021\/ac202713k","volume":"84","author":"Muramoto S.","year":"2012","journal-title":"Anal. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3109\/03009742.2010.547872","volume":"40","author":"Leistad L.","year":"2011","journal-title":"Scand. J. Rheumatol."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1002\/pmic.200800127","volume":"8","author":"Monroe E. B.","year":"2008","journal-title":"Proteomics"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"S317","DOI":"10.1194\/jlr.R800051-JLR200","volume":"50","author":"Murphy R. C.","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1194\/jlr.M015750","volume":"52","author":"Berry K. A.","year":"2011","journal-title":"J. Lipid Res."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1074\/jbc.M111.274142","volume":"287","author":"Chan R. B.","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5858\/2008-0795-OAR1.1","volume":"134","author":"Sepulveda J. L.","year":"2010","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1021\/pr060159w","volume":"5","author":"Alonso-Orgaz S","year":"2006","journal-title":"J. Proteome Res."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0026-0495(91)90046-Y","volume":"40","author":"Lippiello L.","year":"1991","journal-title":"Metabolism"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/ard.24.2.136","volume":"24","author":"Ghadially F. N.","year":"1965","journal-title":"Ann. Rheum. Dis."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1021\/pr901094j","volume":"9","author":"Castro-Perez J. M.","year":"2010","journal-title":"J. Proteome Res."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1756-185X.2011.01618.x","volume":"14","author":"Zamli Z.","year":"2011","journal-title":"Int. J. Rheum. Dis."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00002281-199605000-00015","volume":"8","author":"McCarthy G. M.","year":"1996","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref44\/cit44","first-page":"806","volume":"14","author":"Pritzker K. P.","year":"1987","journal-title":"J. Rheumatol."}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ac301853q","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T20:10:19Z","timestamp":1680811819000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ac301853q"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,11]]},"references-count":44,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2012,11,6]]}},"alternative-id":["10.1021\/ac301853q"],"URL":"https:\/\/doi.org\/10.1021\/ac301853q","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,11]]}}}