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The \u201cheavy\u201d use of cyanide in these industries, along with its necessary transportation, increases the possibility of human exposure. Because the onset of cyanide toxicity is fast, a rapid, sensitive, and accurate method for the diagnosis of cyanide exposure is necessary. Therefore, a field sensor for the diagnosis of cyanide exposure was developed based on the reaction of naphthalene dialdehyde, taurine, and cyanide, yielding a fluorescent \u03b2-isoindole. An integrated cyanide capture \u201capparatus\u201d, consisting of sample and cyanide capture chambers, allowed rapid separation of cyanide from blood samples. Rabbit whole blood was added to the sample chamber, acidified, and the HCN gas evolved was actively transferred through a stainless steel channel to the capture chamber containing a basic solution of naphthalene dialdehyde (NDA) and taurine. The overall analysis time (including the addition of the sample) was &amp;lt;3 min, the linear range was 3.13\u2013200 \u03bcM, and the limit of detection was 0.78 \u03bcM. None of the potential interferents investigated (NaHS, NH4OH, NaSCN, and human serum albumin) produced a signal that could be interpreted as a false positive or a false negative for cyanide exposure. Most importantly, the sensor was 100% accurate in diagnosing cyanide poisoning for acutely exposed rabbits.<\/jats:p>","DOI":"10.1021\/ac403846s","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T03:10:47Z","timestamp":1388718647000},"page":"1845-1852","source":"Crossref","is-referenced-by-count":101,"title":["Development of a Fluorescence-Based Sensor for Rapid\nDiagnosis of Cyanide Exposure"],"prefix":"10.1021","volume":"86","author":[{"given":"Randy","family":"Jackson","sequence":"first","affiliation":[{"name":"South Dakota State University , , Box 2202, , ,","place":["Brookings, South Dakota, United States, 57007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Oda","sequence":"additional","affiliation":[{"name":"South Dakota State University , , Box 2202, , ,","place":["Brookings, South Dakota, United States, 57007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj K.","family":"Bhandari","sequence":"additional","affiliation":[{"name":"South Dakota State University , , Box 2202, , ,","place":["Brookings, South Dakota, United States, 57007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari B.","family":"Mahon","sequence":"additional","affiliation":[{"name":"University of California Beckman Laser Institute and Medical Clinic, , , ,","place":["Irvine, California, United States, 92612"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Brenner","sequence":"additional","affiliation":[{"name":"University of California Beckman Laser Institute and Medical Clinic, , , ,","place":["Irvine, California, United States, 92612"]},{"name":"University of California Division of Pulmonary and Critical Care Medicine, , , , ,","place":["Irvine, California, United States, 92868"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Rockwood","sequence":"additional","affiliation":[{"name":"United States Army Medical Research Institute of Chemical Defense Analytical Toxicology Division, , 3100 Ricketts Point Road , , ,","place":["Aberdeen Proving Ground, Maryland, United States, 21010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Logue","sequence":"additional","affiliation":[{"name":"South Dakota State University , , Box 2202, , ,","place":["Brookings, South Dakota, United States, 57007"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,1,3]]},"reference":[{"key":"2026090202565834900_cit1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/10408340903535315","volume":"40","author":"Logue","year":"2010","journal-title":"Crit. 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