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Res."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0168-3659(96)01534-9","volume":"44","author":"Lee H. K.","year":"1997","journal-title":"J. Controlled Release"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0168-3659(02)00066-4","volume":"81","author":"Wang F. J.","year":"2002","journal-title":"J. Controlled Release"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0168-3659(01)00289-9","volume":"73","author":"Berkland C.","year":"2001","journal-title":"J. Controlled Release"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0168-3659(02)00136-0","volume":"82","author":"Berkland C.","year":"2002","journal-title":"J. Controlled Release"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/026520499289149","volume":"16","author":"Leach K.","year":"1999","journal-title":"J. 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Soc."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1021\/ac0263622","volume":"75","author":"Widjaja E.","year":"2003","journal-title":"Anal. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1366\/000370203322554509","volume":"57","author":"Widjaja E.","year":"2003","journal-title":"Appl. Spectrosc."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1021\/ac701940k","volume":"80","author":"Widjaja E.","year":"2008","journal-title":"Anal. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1021\/ac802234t","volume":"81","author":"Seah R. K. H.","year":"2009","journal-title":"Anal. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jrs.1250260409","volume":"26","author":"Kister G.","year":"1995","journal-title":"J. Raman Spectrosc."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1039\/a806678g","volume":"124","author":"Geze A.","year":"1999","journal-title":"Analyst"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0032-3861(99)00223-2","volume":"41","author":"Kister G.","year":"2000","journal-title":"Polymer"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.eurpolymj.2004.04.022","volume":"40","author":"Misra R. M.","year":"2004","journal-title":"Eur. Polym. J."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0584-8539(97)00039-1","volume":"53","author":"Kister G.","year":"1997","journal-title":"Spectrochim. Acta, Part A"},{"key":"ref26\/cit26","unstructured":"www.sigmaaldrich.com."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S1386-1425(00)00495-9","volume":"57","author":"Burgio L.","year":"2001","journal-title":"Spectrochim. Acta, Part A"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jrs.874","volume":"33","author":"Chaplin T. D.","year":"2002","journal-title":"J. Raman Spectrosc."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1016\/j.biomaterials.2004.10.014","volume":"26","author":"Loo S. C. J.","year":"2005","journal-title":"Biomaterials"},{"key":"ref30\/cit30","unstructured":"Wu, X. S.Synthesis and properties of biodegradable lactic\/glycolic acid polymers. InEncyclopedic handbook of biomaterials and bioengineering;Wise, D. L., Trantolo, D. J., Altobelli, D. E., Yaszemski, M. J., Gresser, J. D., and Schwartz, E. R., Eds.Marcel Dekker:New York, 1995; pp1015\u22121054."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jconrel.2007.11.015","volume":"126","author":"Belu A.","year":"2008","journal-title":"J. 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