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The aim of the present study was a synchrotron-based characterization of micro- and nanosized implant-related particles in inflamed human tissues around titanium and ceramic dental implants that exhibited signs of peri-implantitis. Size, distribution, and chemical speciation of the exogenous micro- and nanosized particle content were evaluated using synchrotron \u03bc-X-ray fluorescence spectroscopy (XRF), nano-XRF, and \u03bc-X-ray absorption near-edge structure (XANES). Titanium particles, with variable speciation, were detected in all tissue sections associated with titanium implants. Ceramic particles were found in five out of eight tissue samples associated with ceramic implants. Particles ranged in size from micro- to nanoscale. The local density of both titanium and ceramic particles was calculated to be as high as \u223c40 million particles\/mm3. \u03bc-XANES identified titanium in predominantly two different chemistries, including metallic and titanium dioxide (TiO2). The findings highlight the propensity for particle accumulation in the inflamed tissues around dental implants and will help in guiding toxicological studies to determine the biological significance of such exposures.<\/jats:p>","DOI":"10.1021\/acs.analchem.0c02416","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T16:50:35Z","timestamp":1600966235000},"page":"14432-14443","source":"Crossref","is-referenced-by-count":50,"title":["Distribution and Chemical Speciation of Exogenous\nMicro- and Nanoparticles in Inflamed Soft Tissue Adjacent to Titanium\nand Ceramic Dental Implants"],"prefix":"10.1021","volume":"92","author":[{"given":"Katja","family":"Nelson","sequence":"first","affiliation":[{"name":"Medical Center-University of Freiburg , , Hugstetter Stra\u00dfe 55 , ,","place":["Freiburg, Germany, 79106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Hesse","sequence":"additional","affiliation":[{"name":"Xploraytion GmbH , Bismarckstrasse 10-12 , ,","place":["Berlin, Germany, 10625"]},{"name":"European Synchrotron Radiation Facility (ESRF) , 71 avenue des Martyrs , ,","place":["Grenoble, France, 38043"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Addison","sequence":"additional","affiliation":[{"name":"King\u2019s College London, Guy\u2019s Hospital , , Great Maze Pond , ,","place":["London, U.K., SE1 9RT"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander P.","family":"Morrell","sequence":"additional","affiliation":[{"name":"King\u2019s College London, Guy\u2019s Hospital , , Great Maze Pond , ,","place":["London, U.K., SE1 9RT"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gross","sequence":"additional","affiliation":[{"name":"Medical Center-University of Freiburg , , Hugstetter Stra\u00dfe 55 , ,","place":["Freiburg, Germany, 79106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Lagrange","sequence":"additional","affiliation":[{"name":"Xploraytion GmbH , Bismarckstrasse 10-12 , ,","place":["Berlin, Germany, 10625"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa I.","family":"Sua\u0301rez","sequence":"additional","affiliation":[{"name":"European Synchrotron Radiation Facility (ESRF) , 71 avenue des Martyrs , ,","place":["Grenoble, France, 38043"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Kohal","sequence":"additional","affiliation":[{"name":"Medical Center-University of Freiburg , , Hugstetter Stra\u00dfe 55 , ,","place":["Freiburg, Germany, 79106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4769-7610","authenticated-orcid":true,"given":"Tobias","family":"Fretwurst","sequence":"additional","affiliation":[{"name":"Medical Center-University of Freiburg , , Hugstetter Stra\u00dfe 55 , ,","place":["Freiburg, Germany, 79106"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"2026090211333380400_cit1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/cid.12142","article-title":"Is Marginal\nBone Loss around Oral Implants the Result\nof a Provoked Foreign Body Reaction?","volume":"16","author":"Albrektsson","year":"2014","journal-title":"Clin.\nImplant Dent. 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