{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:16:11Z","timestamp":1788412571444,"version":"build-2803163510"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["262613"],"award-info":[{"award-number":["262613"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["295910"],"award-info":[{"award-number":["295910"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Liver organoids are emerging tools for precision drug development and toxicity screening. We demonstrate that electromembrane extraction (EME) based on electrophoresis across an oil membrane is suited for segregating selected organoid-derived drug metabolites prior to mass spectrometry (MS)-based measurements. EME allowed drugs and drug metabolites to be separated from cell medium components (albumin, etc.) that could interfere with subsequent measurements. Multiwell EME (parallel-EME) holding 100 \u03bcL solutions allowed for simple and repeatable monitoring of heroin phase I metabolism kinetics. Organoid parallel-EME extracts were compatible with ultrahigh-performance liquid chromatography (UHPLC) used to separate the analytes prior to detection. Taken together, liver organoids are well-matched with EME followed by MS-based measurements.<\/jats:p>","DOI":"10.1021\/acs.analchem.0c05082","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T07:48:28Z","timestamp":1612597708000},"page":"3576-3585","source":"Crossref","is-referenced-by-count":33,"title":["Electromembrane Extraction and Mass Spectrometry for\nLiver Organoid Drug Metabolism Studies"],"prefix":"10.1021","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-2502","authenticated-orcid":true,"given":"Fr\u00f8ydis Sved","family":"Skottvoll","sequence":"first","affiliation":[{"name":"University of Oslo , , P.O. Box 1033, Blindern, ,","place":["Oslo, Norway, NO-0315"]},{"name":"University of Oslo , , P.O. Box 1112, Blindern, ,","place":["Oslo, Norway, NO-0317"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1666-0447","authenticated-orcid":true,"given":"Frederik Andre\u0301","family":"Hansen","sequence":"additional","affiliation":[{"name":"University of Oslo , , P.O. Box 1068, Blindern, ,","place":["Oslo, Norway, NO-0316"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Harrison","sequence":"additional","affiliation":[{"name":"University of Oslo , , P.O. Box 1112, Blindern, ,","place":["Oslo, Norway, NO-0317"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Sneis","family":"Boger","sequence":"additional","affiliation":[{"name":"University of Oslo , , P.O. Box 1033, Blindern, ,","place":["Oslo, Norway, NO-0315"]},{"name":"University of Oslo , , P.O. 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Box 1110, Blindern, , ,","place":["Oslo, Norway, 0317"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Sullivan","sequence":"additional","affiliation":[{"name":"University of Oslo , , P.O. Box 1112, Blindern, ,","place":["Oslo, Norway, NO-0317"]},{"name":"Oslo University Hospital and University of Oslo , , P.O. Box 1112, Blindern, ,","place":["Oslo, Norway, 0317"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger Lise","family":"Bogen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital , , P.O. Box 4950, Nydalen, ,","place":["Oslo, Norway, NO-0424"]},{"name":"University of Oslo , , P.O. Box 1103, Blindern, ,","place":["Oslo, Norway, NO-0317"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-1188","authenticated-orcid":true,"given":"Steven Ray","family":"Wilson","sequence":"additional","affiliation":[{"name":"University of Oslo , , P.O. 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