{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:26:45Z","timestamp":1790094405490,"version":"4.0.1"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001664","name":"Leibniz-Gemeinschaft","doi-asserted-by":"publisher","award":["W8\/2018"],"award-info":[{"award-number":["W8\/2018"]}],"id":[{"id":"10.13039\/501100001664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f?r Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 01EO1502"],"award-info":[{"award-number":["FKZ 01EO1502"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016019","name":"Freistaat Th?ringen","doi-asserted-by":"publisher","award":["FKZ IZN 2018 0002"],"award-info":[{"award-number":["FKZ IZN 2018 0002"]}],"id":[{"id":"10.13039\/100016019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["861122"],"award-info":[{"award-number":["861122"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FLI"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2022,3,29]]},"DOI":"10.1021\/acs.analchem.1c04754","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T18:18:01Z","timestamp":1647627481000},"page":"4988-4996","source":"Crossref","is-referenced-by-count":5,"title":["Looking Inside Non-Destructively: Label-Free, Raman-Based Visualization of Intracellular <i>Coxiella burnetii<\/i>"],"prefix":"10.1021","volume":"94","author":[{"given":"Nancy","family":"Unger","sequence":"first","affiliation":[{"name":"Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany"},{"name":"Leibniz Institute of Photonic Technology, 07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Eiserloh","sequence":"additional","affiliation":[{"name":"Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany"},{"name":"Leibniz Institute of Photonic Technology, 07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Nowak","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathogenesis, Friedrich-Loeffler-Institut\u2500Federal Research Institute for Animal Health (FLI), 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Zuchantke","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathogenesis, Friedrich-Loeffler-Institut\u2500Federal Research Institute for Animal Health (FLI), 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Liebler-Tenorio","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathogenesis, Friedrich-Loeffler-Institut\u2500Federal Research Institute for Animal Health (FLI), 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Sobotta","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Schnee","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathogenesis, Friedrich-Loeffler-Institut\u2500Federal Research Institute for Animal Health (FLI), 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Berens","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathogenesis, Friedrich-Loeffler-Institut\u2500Federal Research Institute for Animal Health (FLI), 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-6132","authenticated-orcid":true,"given":"Ute","family":"Neugebauer","sequence":"additional","affiliation":[{"name":"Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany"},{"name":"Leibniz Institute of Photonic Technology, 07745 Jena, Germany"},{"name":"Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.67"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-015-0136-6"},{"key":"ref3\/cit3a","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.036"},{"key":"ref3\/cit3b","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00564G"},{"key":"ref3\/cit3c","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2019.06.004"},{"key":"ref4\/cit4a","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502746102"},{"key":"ref4\/cit4b","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.102061"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.4844"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/ac503316s"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14843"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19827-1"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3049"},{"key":"ref10\/cit10a","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00045-16"},{"key":"ref10\/cit10b","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2019.5926"},{"key":"ref11\/cit11","unstructured":"Anderson, A.; Bijlmer, H.; Fournier, P. E.; Graves, S.; Hartzell, J.; Kersh, G. J.; Limonard, G.; Marrie, T. J.; Massung, R. F.; McQuiston, J. H.;  Diagnosis and management of Q fever-United States, 2013: recommendations from CDC and the Q Fever Working Group.  MMWR Recommendations and Reports, 2013; Vol. 62 (3), pp 1\u201330."},{"key":"ref12\/cit12a","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-4315-1_12"},{"key":"ref12\/cit12b","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12432"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00883-06"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(99)01475-4"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1128\/jb.186.21.7344-7352.2004"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00293.x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-013-1816-0"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2017.09.010"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149957"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2143-7"},{"key":"ref21\/cit21a","doi-asserted-by":"publisher","DOI":"10.1128\/iai.32.2.840-851.1981"},{"key":"ref21\/cit21b","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00471-17"},{"key":"ref22\/cit22","unstructured":"WITec.  WITec alpha300 Series: Modular Confocal\nRaman Microscopy\nSystems, 2022. https:\/\/www.witec.de\/assets\/Literature\/Files\/WITec-alpha300-Brochure.pdf (accessed Jan 19, 2022)."},{"key":"ref23\/cit23","volume-title":"N-FINDR: an algorithm for fast autonomous spectral end-member determination in hyperspectral data","author":"Winter M.","year":"1999"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00494-6"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-015-8912-y"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-018-1181-0"},{"key":"ref27\/cit27a","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1996.tb02651.x"},{"key":"ref27\/cit27b","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.6741-6750.2002"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9080614"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12494"},{"key":"ref30\/cit30a","doi-asserted-by":"publisher","DOI":"10.1128\/jb.160.3.982-988.1984"},{"key":"ref30\/cit30b","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.9.3243-3253.1991"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2009.07.003"},{"key":"ref32\/cit32a","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00165"},{"key":"ref32\/cit32b","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2015.08.006"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.4607"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.1c04754","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.1c04754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T21:10:37Z","timestamp":1682457037000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.1c04754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,18]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,3,29]]}},"alternative-id":["10.1021\/acs.analchem.1c04754"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.1c04754","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,18]]}}}