{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:33:48Z","timestamp":1791819228023,"version":"4.3.4"},"reference-count":82,"publisher":"American Chemical Society (ACS)","issue":"16","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2022,4,26]]},"DOI":"10.1021\/acs.analchem.1c05093","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T07:45:49Z","timestamp":1649749549000},"page":"6146-6155","source":"Crossref","is-referenced-by-count":6,"title":["Development of an Aptamer-Based Electrochemical Microfluidic Device for Viral Vaccine Quantitation"],"prefix":"10.1021","volume":"94","author":[{"given":"Tyler","family":"Chozinski","sequence":"first","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Scott","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Fisher","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shencheng","family":"Ge","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Gong","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Kang","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McDermott","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Scott","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Shi","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2120-3870","authenticated-orcid":true,"given":"Jeremiah J.","family":"Trausch","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-9226","authenticated-orcid":true,"given":"Thorsten","family":"Verch","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Vukovich","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Emma","family":"Wu","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yang","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, 125 Cremona Drive, Suite 100, Goleta, California 93117, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1261"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1057\/palgrave.jphp.3190016"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.8.2.227"},{"key":"ref4\/cit4","first-page":"1","volume":"926","author":"World Health Organization","year":"2004","journal-title":"World Health Organ. Technol. Rep. Ser."},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3390\/ani1040414"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-45024-6"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.4155\/bio.13.198"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.4155\/bio-2017-0176"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.4161\/hv.1.5.2126"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2018.08.002"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.4161\/hv.29205"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.4155\/bio-2020-0023"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2010.04.025"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/etc.2503"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2020.112041"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.602659"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mee.2014.09.024"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar6076"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201100464"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10060236"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01986"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01182"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2020.105677"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1126\/science.2200121"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/346818a0"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24234377"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-017-0076"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.04.003"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00283"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2015.04.041"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201608880"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2019.01.012"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00582-z"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6156581"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/v10120704"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jala.2010.01.013"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1388"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201601403"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-005-1587-y"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-018-0036-7"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/elan.201800632"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2019.127017"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/ac0608265"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1089\/154065802761001347"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305584"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1507"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201001005"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/s17040684"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/ac100044c"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/ja507849b"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1039\/D1AN00629K"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1641"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/celc.201600758"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs35528d"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007095"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/ar900165x"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0045-y"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2018.12.001"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.coelec.2019.05.014"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.0c01085"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1613458114"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b00850"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140349"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1405679111"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2014.02.004"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz141"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf9387"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00747-19"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02033-16"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1391433"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52906-y"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.3.1202-1211.2004"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006601"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01910-07"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.532580"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/ja908035g"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1021\/jm00059a007"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1126\/science.1857967"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1021\/ac202638y"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.03.015"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1021\/ac5025254"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b02376"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.1c05093","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.1c05093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T15:50:55Z","timestamp":1682610655000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.1c05093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,12]]},"references-count":82,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,4,26]]}},"alternative-id":["10.1021\/acs.analchem.1c05093"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.1c05093","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,12]]}}}