{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:10:14Z","timestamp":1791583814678,"version":"4.3.4"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"26","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","award":["201809-2016862"],"award-info":[{"award-number":["201809-2016862"]}],"id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010815","name":"Stiftelsen f?r Gamla Tj?narinnor","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK071801"],"award-info":[{"award-number":["R01DK071801"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG078794"],"award-info":[{"award-number":["R01AG078794"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG065728"],"award-info":[{"award-number":["R21AG065728"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG052324"],"award-info":[{"award-number":["RF1AG052324"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007436","name":"Familjen Erling-Perssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P41GM108538"],"award-info":[{"award-number":["P41GM108538"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr?det","doi-asserted-by":"publisher","award":["2018-02532"],"award-info":[{"award-number":["2018-02532"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ADSF-21- 831381-C"],"award-info":[{"award-number":["ADSF-21- 831381-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ADSF-21-831376-C"],"award-info":[{"award-number":["ADSF-21-831376-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ADSF-21-831377-C"],"award-info":[{"award-number":["ADSF-21-831377-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["860197"],"award-info":[{"award-number":["860197"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj?rnfonden","doi-asserted-by":"publisher","award":["FO2022-0270"],"award-info":[{"award-number":["FO2022-0270"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}],"id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["101053962"],"award-info":[{"award-number":["101053962"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["681712"],"award-info":[{"award-number":["681712"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021720","name":"Olav Thon Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022473","name":"American Society for Mass Spectrometry","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100022473","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bluefield Project"},{"name":"AD Strategic Fund"},{"name":"Swedish State Support for Clinical Research","award":["ALFGBG-71320"],"award-info":[{"award-number":["ALFGBG-71320"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2023,7,4]]},"DOI":"10.1021\/acs.analchem.2c05731","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T15:39:57Z","timestamp":1686584397000},"page":"9746-9753","source":"Crossref","is-referenced-by-count":21,"title":["DiLeu Isobaric Labeling Coupled with Limited Proteolysis Mass Spectrometry for High-Throughput Profiling of Protein Structural Changes in Alzheimer\u2019s Disease"],"prefix":"10.1021","volume":"95","author":[{"given":"Haiyan","family":"Lu","sequence":"first","affiliation":[{"name":"School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-9675","authenticated-orcid":true,"given":"Danqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8155-642X","authenticated-orcid":true,"given":"Lauren","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Shi","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53792, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 43141 Gothenburg, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal 43130, Sweden"},{"name":"Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, U.K."},{"name":"UK Dementia Research Institute at UCL, London WC1N 3BG, U.K."},{"name":"Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0056-3869","authenticated-orcid":true,"given":"Lingjun","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States"},{"name":"Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States"},{"name":"Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25051195"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2999"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.100"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.101304.123901"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.12.015"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310249110"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12309"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.0c00912"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.12.023"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2021.03.003"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.07.082"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1221"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/ja053565+"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-1669(02)00332-4"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/nature07814"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai7825"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.031"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-anchem-061516-045357"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b03148"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/pr400098r"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ac503276z"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c00473"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/ac101679j"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/ac401148z"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c07771"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800544"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-014-7736-5"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)00537-3"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.031591"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21595"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202000011"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/ac902778d"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.0c00450"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/s41596-022-00771-x","volume":"18","author":"Malinovska L.","year":"2022","journal-title":"Nat. Protoc."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00867-z"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100501"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11050583"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1901068"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006346"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.09.018"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/path.5203"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.833402"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.03.004"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-022327"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000604"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.29595"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071495"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101340"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00474-z"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.2c05731","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.2c05731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T09:11:48Z","timestamp":1688461908000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.2c05731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,12]]},"references-count":50,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2023,7,4]]}},"alternative-id":["10.1021\/acs.analchem.2c05731"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.2c05731","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,12]]}}}