{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T13:47:12Z","timestamp":1792936032787,"version":"4.5.0"},"reference-count":110,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2024,2,27]]},"DOI":"10.1021\/acs.analchem.3c04231","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T20:34:44Z","timestamp":1706819684000},"page":"3345-3353","source":"Crossref","is-referenced-by-count":11,"title":["Spectrally Resolved and Highly Parallelized Raman Difference Spectroscopy for the Analysis of Drug\u2013Target Interactions between the Antimalarial Drug Chloroquine and Hematin"],"prefix":"10.1021","volume":"96","author":[{"given":"Sebastian","family":"Wolf","sequence":"first","affiliation":[{"name":"Leibniz Institute of Photonic Technology, 07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Domes","sequence":"additional","affiliation":[{"name":"Leibniz Institute of Photonic Technology, 07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Domes","sequence":"additional","affiliation":[{"name":"Leibniz Institute of Photonic Technology, 07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3358-8878","authenticated-orcid":true,"given":"Torsten","family":"Frosch","sequence":"additional","affiliation":[{"name":"Biophotonics and Biomedical Engineering Group, Technical University Darmstadt, Merckstr. 25, 64283 Darmstadt, Germany"},{"name":"Leibniz Institute of Photonic Technology, 07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"ref1\/cit1","unstructured":"Organization, W. H. World Malaria Report 2020; 978-92-4-001579-1; World Health Organization: Geneva, 2020."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","unstructured":"Greenwood, B.; Mutabingwa, T. Malaria in 2002; Nature Publishing Group, 2002.","DOI":"10.1038\/415670a"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.51.1.97"},{"key":"ref4\/cit4","unstructured":"Bohle, D. S.; Conklin, B. J.; Cox, D.; Madsen, S. K.; Paulson, S.; Stephens, P. W.; Yee, G. T. Structural and Spectroscopic Studies of {beta}-hematin (the Heme Coordination Polymer in Malaria Pigment); 0097-6156; Brookhaven National Lab.: Upton, NY (US), 1999."},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.2.325"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)00510-8"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501023112"},{"issue":"1","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0021-9258(17)41115-X","volume":"171","author":"Shack J.","year":"1947","journal-title":"J. Biol. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)80267-4"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)86127-7"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/202805a0"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/223960a0"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3061(00)80056-3"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-006-0170-1"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/ic900647y"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1039\/C7CP04858K"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.solidstatesciences.2017.01.007"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-010-0661-y"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3592"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(00)00058-1"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ja00221a045"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(97)00086-X"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/jm0408013"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(82)80382-9"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(85)90167-9"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2015.06.010"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/bi020195i"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/jm701478a"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00692-6"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.2174\/1874383800802010010"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jp0342982"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s11243-014-9868-z"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1039\/C8DT03369B"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","DOI":"10.1002\/0470845767","volume-title":"The Raman Effect: A Unified Treatment of the Theory of Raman Scattering by Molecules","author":"Long D. A.","year":"2002"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1515\/nanoph-2019-0401"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b01355"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c01500"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/D3AN00402C"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c02507"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1039\/C7AY02398G"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1039\/C7AN01149K"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24244512"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b03312"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1117\/1.3432656"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c00539"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2008.12.019"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/jp066999f"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/ac061526q"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20459"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/jp065136j"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1039\/C7CP05415G"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-006-0754-1"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.clispe.2023.100026"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/jp811028a"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1039\/b821705j"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.02.062"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/jp071788b"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/ja038691x"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c01415"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/ac070440+"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c00222"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2022.132949"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.1252"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.1471"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.02.062"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/ja00487a017"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2860(98)80052-5"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2011.08.005"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1039\/j19660000472"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910123116"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00154"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003323200"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2020.03.010"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24234381"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b03209"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24183229"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.08.025"},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s004360000317","volume":"87","author":"Delha\u00ebs L.","year":"2001","journal-title":"Parasitol. Res."},{"key":"ref80\/cit80","unstructured":"The MathWorks Inc.  MATLAB Version:\n9.11 (R2021b) Update 6; The MathWorks Inc.: Natick, Massachusetts,\nUnited States, 2021."},{"key":"ref81\/cit81","unstructured":"The MathWorks Inc.  Curve\nFitting Toolbox Version 3.6 (R2021b); The\nMathWorks Inc.: Natick, Massachusetts,\nUnited States, 2021."},{"key":"ref82\/cit82","unstructured":"The MathWorks Inc.  Signal\nProcessing Toolbox Version 8.7 (R2021b); The MathWorks Inc.: Natick, Massachusetts,\nUnited States, 2021."},{"key":"ref83\/cit83","unstructured":"The MathWorks Inc.  Statistics\nand Machine Learning Toolbox Version 12.2 (R2021b); The MathWorks Inc.: Natick, Massachusetts,\nUnited States, 2021."},{"key":"ref84\/cit84","unstructured":"Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Petersson, G. A.; Nakatsuji, H.; Li, X.; Caricato, M.; Marenich, A. V.; Bloino, J.; Janesko, B. G.; Gomperts, R.; Mennucci, B.; Hratchian, H. P.; Ortiz, J. V.; Izmaylov, A. F.; Sonnenberg, J. L.; Williams; Ding, F.; Lipparini, F.; Egidi, F.; Goings, J.; Peng, B.; Petrone, A.; Henderson, T.; Ranasinghe, D.; Zakrzewski, V. G.; Gao, J.; Rega, N.; Zheng, G.; Liang, W.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Throssell, K.; Montgomery, J. A., Jr.; Peralta, J. E.; Ogliaro, F.; Bearpark, M. J.; Heyd, J. J.; Brothers, E. N.; Kudin, K. N.; Staroverov, V. N.; Keith, T. A.; Kobayashi, R.; Normand, J.; Raghavachari, K.; Rendell, A. P.; Burant, J. C.; Iyengar, S. S.; Tomasi, J.; Cossi, M.; Millam, J. M.; Klene, M.; Adamo, C.; Cammi, R.; Ochterski, J. W.; Martin, R. L.; Morokuma, K.; Farkas, O.; Foresman, J. B.; Fox, D. J. Gaussian 16; Wallingford: CT, 2016."},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1007\/s00214-007-0310-x"},{"key":"ref86\/cit86","first-page":"1","volume-title":"Methods of Electronic Structure Theory","volume":"1","author":"Dunning T. H.","year":"1977"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1063\/1.448800"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1021\/jp011945l"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1063\/1.448799"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1021\/ct8000409"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1021\/ic8002838"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199610)17:13<1571::AID-JCC9>3.0.CO;2-P"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1021\/ci600510j"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00725"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1038\/203640a0"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC05328A"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1021\/jp810292n"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.8b01751"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.44-0741"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1063\/1.472902"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1080\/00268977000101561"},{"key":"ref102\/cit102","first-page":"64","volume":"1","author":"Bader R. F. W.","year":"2002","journal-title":"Encycl. Comput. Chem."},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1021\/cr800346f"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1063\/1.1877092"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2614(98)00036-0"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.22885"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1021\/ja00342a020"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1021\/ic00160a015"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.061499"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003085"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V62.6.1165.1165"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.3c04231","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.3c04231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T13:32:41Z","timestamp":1709040761000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.3c04231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":110,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,2,27]]}},"alternative-id":["10.1021\/acs.analchem.3c04231"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.3c04231","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]}}}