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Real-time monitoring of endocytosis provides valuable insights into the lysosomal effects on nanocarriers and the release of nanodrugs. We report the development of a coresponsive probe that detects changes in the spatial viscosity of the intracellular domain caused by lysosomal degradation of foreign bodies. The probe, based on a benzofuro\u00ad[2,3-d]\u00adpyrimidine structure, exhibits torsional intramolecular charge transfer (TICT) and responds to ambient viscosity changes with a sensitive fluorescence intensity. The antidiffused fluorescence transition of the probe in the spatially restricted domain serves as a key indicator for real-time monitoring. When encapsulated with diverse foreign bodies and emitted into macrophages by endocytosis, the probe forms nanoparticles. Lysosomes uptake these materials for intracellular digestion, causing alterations in the aggregation or depolymerization state of the nanoparticles, leading to viscosity changes manifested by the probe\u2019s fluorescence. By studying the spatial viscosity changes caused by lysosomal degradation of foreign bodies, our monitoring strategy contributes to understanding the digestion or escape capabilities of potential pharmaceutical-carrying nanocarriers, providing guidelines to design more effective nanocarriers that navigate lysosomal degradation to achieve precise drug payloads and release.<\/jats:p>","DOI":"10.1021\/acs.analchem.4c02729","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:33:30Z","timestamp":1724027610000},"page":"13953-13961","source":"Crossref","is-referenced-by-count":5,"title":["Twisted Intramolecular\nCharge Transfer-Based Viscosity-Responsive\nProbe Reveals Lysosomal Degradation Process of Endocytosed Foreign\nBodies"],"prefix":"10.1021","volume":"96","author":[{"given":"He","family":"Li","sequence":"first","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaijiang","family":"Li","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiheng","family":"Kong","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongmei","family":"Kong","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6311-3051","authenticated-orcid":true,"given":"Fengli","family":"Qu","sequence":"additional","affiliation":[{"name":"Qufu Normal University , , , ,","place":["Qufu, Shandong, China, 273165"]},{"name":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences , , ,","place":["Hangzhou, Zhejiang, China, 310022"]},{"name":"Hangzhou Institute for Advanced Study, UCAS , , , ,","place":["Hangzhou, Zhejiang, China, 310024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-1524","authenticated-orcid":true,"given":"Weihong","family":"Tan","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences , , ,","place":["Hangzhou, Zhejiang, China, 310022"]},{"name":"Hangzhou Institute for Advanced Study, UCAS , , , ,","place":["Hangzhou, Zhejiang, China, 310024"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"issue":"44","key":"2026081706132498900_cit1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202308761","article-title":"Liposomal enzyme nanoreactors based\non nanoconfinement for efficient antitumor therapy","volume":"62","author":"Wang","year":"2023","journal-title":"Angew. 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