{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:50:25Z","timestamp":1790873425517,"version":"4.1.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["015.015.009"],"award-info":[{"award-number":["015.015.009"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VI.C.192.024"],"award-info":[{"award-number":["VI.C.192.024"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Understanding and controlling peptide aggregation are critical due to its neurotoxic implications. However, structural information about the key intermediates, the oligomers, is obscured by a cascade of coinciding events occurring at various time and energy scales, which results in complex and heterogeneous mixtures of oligomers. To address this challenge, we have developed the Photo-Synapt, a novel, multidimensional spectrometer that integrates ion mobility mass spectrometry with infrared (IR) action spectroscopy within a single experiment. By combining three different orthogonal analytical dimensions, we can select and isolate individual oligomers by mass, charge, size, and shape and provide a unique molecular fingerprint for each oligomer. The broad application of this technology is demonstrated by its application to oligosaccharide analysis from glycoproteins, which are challenging to analyze due to the minute differences between isomers. By integration of IR action spectroscopy with ion mobility mass spectrometry, this approach adds an analytical dimension that effectively addresses this limitation, offering a unique molecular fingerprint for each isomer.<\/jats:p>","DOI":"10.1021\/acs.analchem.4c02749","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T08:54:06Z","timestamp":1723798446000},"page":"13962-13970","source":"Crossref","is-referenced-by-count":14,"title":["Probing High-Order\nTransient Oligomers Using Ion Mobility\nMass Spectrometry Coupled with Infrared Action Spectroscopy"],"prefix":"10.1021","volume":"96","author":[{"given":"Sjors","family":"Bakels","sequence":"first","affiliation":[{"name":"Vrije Universiteit Amsterdam , , De Boelelaan 1105 , ,","place":["Amsterdam, The Netherlands, 1081 HV"]},{"name":"Centre for Analytical Sciences Amsterdam , ,","place":["Amsterdam, The Netherlands, 1098 XH"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-8247","authenticated-orcid":true,"given":"Steven","family":"Daly","sequence":"additional","affiliation":[{"name":"MS Vision, Spectrometry Vision B.V. , Televisieweg 40 , ,","place":["Almere, The Netherlands, 1322 AM"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berk","family":"Dog\u0306an","sequence":"additional","affiliation":[{"name":"MS Vision, Spectrometry Vision B.V. , Televisieweg 40 , ,","place":["Almere, The Netherlands, 1322 AM"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2855-924X","authenticated-orcid":true,"given":"Melissa","family":"Baerenfaenger","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam , , De Boelelaan 1105 , ,","place":["Amsterdam, The Netherlands, 1081 HV"]},{"name":"Centre for Analytical Sciences Amsterdam , ,","place":["Amsterdam, The Netherlands, 1098 XH"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Commandeur","sequence":"additional","affiliation":[{"name":"MS Vision, Spectrometry Vision B.V. , Televisieweg 40 , ,","place":["Almere, The Netherlands, 1322 AM"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7446-9907","authenticated-orcid":true,"given":"Anouk M.","family":"Rijs","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam , , De Boelelaan 1105 , ,","place":["Amsterdam, The Netherlands, 1081 HV"]},{"name":"Centre for Analytical Sciences Amsterdam , ,","place":["Amsterdam, The Netherlands, 1098 XH"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"issue":"7","key":"2026081706115251300_cit1","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.jasms.2010.02.026","article-title":"Mass spectrometry\nand the amyloid problem--how far can we go in the gas phase?","volume":"21","author":"Ashcroft","year":"2010","journal-title":"J. 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