{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:08:16Z","timestamp":1780938496578,"version":"3.54.1"},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2023M743405"],"award-info":[{"award-number":["2023M743405"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2024T170880"],"award-info":[{"award-number":["2024T170880"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Talent Project for Special Posts of Universities in Longgang District","award":["2024TD0009"],"award-info":[{"award-number":["2024TD0009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2025,1,21]]},"DOI":"10.1021\/acs.analchem.4c04442","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:31:36Z","timestamp":1736487096000},"page":"1199-1209","source":"Crossref","is-referenced-by-count":4,"title":["Unraveling the Synergistic Neuroprotective Mechanism of Natural Drug Candidates Targeting TRPV1 and TRPM8 on an Ischemic Stroke"],"prefix":"10.1021","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1799-3941","authenticated-orcid":true,"given":"Lijuan","family":"Ma","sequence":"first","affiliation":[{"name":"Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofu","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Wang","sequence":"additional","affiliation":[{"name":"China Beijing Tongrentang Group Co., Ltd., Beijing 100062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunan","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshuang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-9728","authenticated-orcid":true,"given":"Zhisheng","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Du","sequence":"additional","affiliation":[{"name":"Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30962-X"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00277-6"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2014.01.003"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00230-9"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666131228204246"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121288109"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012806"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.08.026"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666181120155953"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-2938-1"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1124\/pr.113.008268"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23529"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nature12822"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01429-2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/112_2012_8"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)80018-W"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00268-4"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9334"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000229"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2127"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02553-4"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00070"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nature13083"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.02.031"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.606682"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154437"},{"issue":"07","key":"ref29\/cit29","first-page":"1606","volume":"46","author":"Lei L. T.","year":"2021","journal-title":"China J. Chin. Mater. Med."},{"key":"ref30\/cit30","unstructured":"Wu, Z. S.; Ma, L. J.; Lei, L. T. A method for identifying potential taste and efficacy critical quality attributes of traditional Chinese medicine preparations. Patent CN113012820A. 2021."},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15011"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115475"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117192"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2018.11.046"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2013.11.020"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2017.01.064"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2012.08.074"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204076"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.68"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113608"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2015.01.120"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b04455"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.01.004"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/D2GC03835H"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2023.116951"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113780"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2020.112779"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.11.004"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-016-0353-7"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12040339"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2007.03.005"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705652"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1213337"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1835"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.4c04442","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.4c04442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T09:11:53Z","timestamp":1737450713000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.4c04442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,21]]}},"alternative-id":["10.1021\/acs.analchem.4c04442"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.4c04442","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,10]]}}}