{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:44:12Z","timestamp":1791924252175,"version":"4.3.4"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"51","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2024,12,24]]},"DOI":"10.1021\/acs.analchem.4c04586","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T14:16:42Z","timestamp":1734013002000},"page":"20239-20246","source":"Crossref","is-referenced-by-count":2,"title":["Detecting Colorectal Neoplasia Using Specific Fecal Fluorogenic Protease-Sensitive Substrates: A Pilot Study"],"prefix":"10.1021","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-0940","authenticated-orcid":true,"given":"Roza C. M.","family":"Opperman","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute, 1081 HV Amsterdam, The Netherlands"},{"name":"Research Program, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Nazmi","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris J.","family":"Bikker","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk S.","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie R.","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Research Program, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands"},{"name":"Department of Medical Oncology, Amsterdam UMC, VU University Medical Center, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim G. J.","family":"de Meij","sequence":"additional","affiliation":[{"name":"Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute, 1081 HV Amsterdam, The Netherlands"},{"name":"Department of Pediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands"},{"name":"Department of Pediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam UMC, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Dekker","sequence":"additional","affiliation":[{"name":"Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute, 1081 HV Amsterdam, The Netherlands"},{"name":"Research Program, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanne K. H.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0159-2816","authenticated-orcid":true,"given":"Wendy E.","family":"Kaman","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.08.059"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2208375"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-309086"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307508"},{"key":"ref6\/cit6","unstructured":"Bevolkingsonderzoek Darmkanker Factsheet 2023; Ministerie van Volksgezondheid WeS, 2022; p 5."},{"key":"ref7\/cit7","volume-title":"Evaluatie en optimalisatie van het bevolkingsonderzoek darmkanker","year":"2022"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.10417"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052514"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2075-1"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991001)86:7<1135::AID-CNCR6>3.0.CO;2-2"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.408"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers6010366"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600366"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2139979"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-014-9611-4"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2013.06.015"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/ac102764v"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1052"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp971"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2038863"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327156"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.11.007"},{"issue":"4","key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1042\/bj1330709","volume":"133","author":"Barrett A.","year":"1973","journal-title":"Biochem. J."},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202302190r"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067100"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/nrc884"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01059-X"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-170967"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2018.19.5.1277"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.07.022"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188357"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143602"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.12.002"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2181922"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.4c04586","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.4c04586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T09:32:12Z","timestamp":1735032732000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.4c04586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":35,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2024,12,24]]}},"alternative-id":["10.1021\/acs.analchem.4c04586"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.4c04586","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]}}}