{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:40:19Z","timestamp":1790948419928,"version":"4.1.0"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202211080"],"award-info":[{"award-number":["tsqn202211080"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["22CX06012A"],"award-info":[{"award-number":["22CX06012A"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["24CX03011A"],"award-info":[{"award-number":["24CX03011A"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22003076"],"award-info":[{"award-number":["22003076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22476214"],"award-info":[{"award-number":["22476214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022JQ07"],"award-info":[{"award-number":["ZR2022JQ07"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MB014"],"award-info":[{"award-number":["ZR2024MB014"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Fundamental Project of Qingdao","award":["24-8-4-zrjj-0-jch"],"award-info":[{"award-number":["24-8-4-zrjj-0-jch"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2025,9,16]]},"DOI":"10.1021\/acs.analchem.5c02678","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T03:19:25Z","timestamp":1756783165000},"page":"19552-19559","source":"Crossref","is-referenced-by-count":7,"title":["CRISPR-Driven Portable Piezoresistive Biosensor with Cascaded Signal Amplification for Ultrasensitive Osteocalcin Detection"],"prefix":"10.1021","volume":"97","author":[{"given":"Xiang","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Safety, College of Chemistry and Chemical Engineering","place":["Qingdao, PR China"]},{"name":"China University of Petroleum (East China)","place":["Qingdao, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenkang","family":"Liu","sequence":"additional","affiliation":[{"name":"Xidian University","place":["Xian, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengchen","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Safety, College of Chemistry and Chemical Engineering","place":["Qingdao, PR China"]},{"name":"China University of Petroleum (East China)","place":["Qingdao, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Safety, College of Chemistry and Chemical Engineering","place":["Qingdao, PR China"]},{"name":"China University of Petroleum (East China)","place":["Qingdao, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqian","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Safety, College of Chemistry and Chemical Engineering","place":["Qingdao, PR China"]},{"name":"China University of Petroleum (East China)","place":["Qingdao, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abulaiti","family":"Tuerhongjiang","sequence":"additional","affiliation":[{"name":"Petrochina Urumqi Petrochemical Quality Inspection Center","place":["Urumqi, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Liu","sequence":"additional","affiliation":[{"name":"Huangdao Customs of the People\u2019s Republic of China","place":["Qingdao, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-8867","authenticated-orcid":true,"given":"Jingbin","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Safety, College of Chemistry and Chemical Engineering","place":["Qingdao, PR China"]},{"name":"China University of Petroleum (East China)","place":["Qingdao, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-7694","authenticated-orcid":true,"given":"Cong-Ying","family":"Wen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Safety, College of Chemistry and Chemical Engineering","place":["Qingdao, PR China"]},{"name":"China University of Petroleum (East China)","place":["Qingdao, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319867505"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c18829"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202500115"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4678"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00826-3"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvae012"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-025-07380-5"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-022-05432-5"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2023.133898"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.145110"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.138296"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c01133"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c03249"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.115028"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.140789"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.142630"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110331"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s12598-023-02387-w"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam9321"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav4294"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c12754"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202115907"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2025.118174"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.5c00020"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.5c00330"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215536"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c04761"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-022-01179-0"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c03220"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1007\/s12598-025-03326-7"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c07612"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0001-1"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.260"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c12605"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210551"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2024.117064"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121818"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114282"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.5c02678","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.5c02678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:13:20Z","timestamp":1758010400000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c02678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":38,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2025,9,16]]}},"alternative-id":["10.1021\/acs.analchem.5c02678"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.5c02678","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]}}}