{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:24:17Z","timestamp":1792797857297,"version":"4.5.0"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374104"],"award-info":[{"award-number":["22374104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2026,2,17]]},"DOI":"10.1021\/acs.analchem.5c04084","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T16:23:44Z","timestamp":1770395024000},"page":"4508-4517","source":"Crossref","is-referenced-by-count":1,"title":["Wet\u2013Dry\u2013Wet Experiments Enable Simultaneous Aptamer Isolation and Critical Binding Domain Identification"],"prefix":"10.1021","volume":"98","author":[{"given":"Keyi","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Capital Normal University, Xisanhuan North Road 105, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Capital Normal University, Xisanhuan North Road 105, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Capital Normal University, Xisanhuan North Road 105, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Capital Normal University, Xisanhuan North Road 105, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rugui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Capital Normal University, Xisanhuan North Road 105, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Capital Normal University, Xisanhuan North Road 105, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Capital Normal University, Xisanhuan North Road 105, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-713X","authenticated-orcid":true,"given":"Xinhui","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Capital Normal University, Xisanhuan North Road 105, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.11.001"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2016.04.032"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.9.1963"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1039\/c2ra20307c"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx517"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113702"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020356"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1039\/D4TB00909F"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073605"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1364"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01307-0"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","unstructured":"Carbonell, J. G.; Michalski, R. S.; Mitchell, T. M.\n                      Machine Learning: An Artificial Intelligence Approach\n                      ; Springer: Berlin, 1983; pp 3\u201323.","DOI":"10.1016\/B978-0-08-051054-5.50005-4"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","unstructured":"Marcus, G. Deep learning: A critical appraisal.\n                      arXiv\n                      2018,10.48550\/arXiv.1801.00631.","DOI":"10.48550\/arXiv.1801.00631"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2014.09.003"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s43588-022-00249-6"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1010774"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-023-05577-6"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31955-4"},{"key":"ref20\/cit20","unstructured":"Wornow, M.\n                      Applying Deep Learning to Discover Highly Functionalized Nucleic Acid Polymers That Bind to Small Molecules\n                      . Bachelor\u2019s thesis, Harvard College, 2020; pp 1\u201398."},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1139\/y77-007"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.2515\/therapie\/2010025"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao6750"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1010561"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/ja2084256"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/ac301899h"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.5c04084","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.5c04084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T01:29:43Z","timestamp":1772674183000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c04084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,2,17]]}},"alternative-id":["10.1021\/acs.analchem.5c04084"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.5c04084","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]}}}