{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:33:46Z","timestamp":1790627626223,"version":"4.1.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["23JCJQJC00200"],"award-info":[{"award-number":["23JCJQJC00200"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22174072"],"award-info":[{"award-number":["22174072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22425401"],"award-info":[{"award-number":["22425401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373115"],"award-info":[{"award-number":["82373115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Medical Research Fund","award":["D2401013"],"award-info":[{"award-number":["D2401013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2025,9,16]]},"DOI":"10.1021\/acs.analchem.5c04102","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T19:57:24Z","timestamp":1757015844000},"page":"19900-19908","source":"Crossref","is-referenced-by-count":5,"title":["Transcriptome Analysis of Tear-Derived Extracellular Vesicles as Biomarkers for Diabetic Retinopathy"],"prefix":"10.1021","volume":"97","author":[{"given":"Jiaming","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Frontiers Science Center for New Organic Matter, College of Chemistry","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6741-9546","authenticated-orcid":true,"given":"Zhaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Frontiers Science Center for New Organic Matter, College of Chemistry","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Hong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Frontiers Science Center for New Organic Matter, College of Chemistry","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Kang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Frontiers Science Center for New Organic Matter, College of Chemistry","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Frontiers Science Center for New Organic Matter, College of Chemistry","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Frontiers Science Center for New Organic Matter, College of Chemistry","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Frontiers Science Center for New Organic Matter, College of Chemistry","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofeng","family":"Ding","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology","place":["Tianjin, China"]},{"name":"Tianjin Medical University","place":["Tianjin, China"]},{"name":"Tianjin Key Lab of Ophthalmology and Vision Science","place":["Tianjin, China"]},{"name":"Tianjin Eye Hospital","place":["Tianjin, China"]},{"name":"Nankai University Eye Institute, Nankai University Affiliated Eye Hospital, Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry","place":["Tianjin, China"]},{"name":"Tianjin Medical University Eye Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-9822","authenticated-orcid":true,"given":"Dingbin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Frontiers Science Center for New Organic Matter, College of Chemistry","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1205011#SA1"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.04.027"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-00451-4"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39864-w"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.03.024"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2024.101271"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00299-w"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-023-00240-z"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.010"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02426-6"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202417165"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v5.30829"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.06.021"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c00280"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.7150\/thno.107213"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57633-9"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12300"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c16698"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/ac202061v"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c01978"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c00035"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c02531"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf4568"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-024-09911-1"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.7748\/ns.2021.e11696"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1003934"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000843"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0064-9"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1089\/tmj.2015.0068"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-022-00162-2"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.3616"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c08486"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.7150\/thno.92463"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg1137"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15589"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.5c04102","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.5c04102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:11:58Z","timestamp":1758010318000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c04102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":35,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2025,9,16]]}},"alternative-id":["10.1021\/acs.analchem.5c04102"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.5c04102","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]}}}