{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:30:23Z","timestamp":1770813023931,"version":"3.50.1"},"reference-count":27,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI153564"],"award-info":[{"award-number":["1R01AI153564"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2026,2,10]]},"DOI":"10.1021\/acs.analchem.5c06280","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T15:56:31Z","timestamp":1769702191000},"page":"3951-3958","source":"Crossref","is-referenced-by-count":0,"title":["Automated Enrichment of DNA Biomarkers from Large-Volume Samples: Detection of\n                    <i>B. burgdorferi<\/i>\n                    Cell-Free DNA in Urine"],"prefix":"10.1021","volume":"98","author":[{"given":"Alie M.","family":"Bogusch","sequence":"first","affiliation":[{"name":"Fischell Department of Bioengineering","place":["College Park, United States"]},{"name":"University of Maryland","place":["College Park, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan H.","family":"Benke","sequence":"additional","affiliation":[{"name":"Fischell Department of Bioengineering","place":["College Park, United States"]},{"name":"University of Maryland","place":["College Park, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan T.","family":"Ruit","sequence":"additional","affiliation":[{"name":"Fischell Department of Bioengineering","place":["College Park, United States"]},{"name":"University of Maryland","place":["College Park, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham A.","family":"Akinladenu","sequence":"additional","affiliation":[{"name":"Fischell Department of Bioengineering","place":["College Park, United States"]},{"name":"University of Maryland","place":["College Park, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8900-5208","authenticated-orcid":true,"given":"David J.","family":"Boegner","sequence":"additional","affiliation":[{"name":"Fischell Department of Bioengineering","place":["College Park, United States"]},{"name":"University of Maryland","place":["College Park, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-9311","authenticated-orcid":true,"given":"Ian M.","family":"White","sequence":"additional","affiliation":[{"name":"Fischell Department of Bioengineering","place":["College Park, United States"]},{"name":"University of Maryland","place":["College Park, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.50176"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01351-y"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2022.100259"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007094"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136133"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2012.10.014"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101198"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12776"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02681-x"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1088\/2516-1091\/ac1ea3"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-022-00446-4"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-022-00409-w"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69432-x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvac122"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2006.05.005"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247851"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00074-21"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c00493"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","unstructured":"Benke, E.; Boegner, D.; Bogusch, A.; White, I. Sample-to-Answer Detection of Mirna from Whole Blood Using Thermally Responsive Alkane Partitions. 2024.10.2139\/ssrn.5008059.","DOI":"10.2139\/ssrn.5008059"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c02105"},{"key":"ref21\/cit21","unstructured":"CDC.\n                      Lyme Disease Surveillance and Data\n                      . Lyme Disease. https:\/\/www.cdc.gov\/lyme\/data-research\/facts-stats\/index.html (accessed 2025-09-14)."},{"key":"ref22\/cit22","volume-title":"Lyme Disease Treatment | Prognosis for Lyme Patients after Treatment"},{"key":"ref23\/cit23","unstructured":"CDC.\n                      About Lyme Disease\n                      . Lyme Disease. https:\/\/www.cdc.gov\/lyme\/about\/index.html (accessed 2025-09-14)."},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3201\/eid2207.151694"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.9.2658-2665.1998"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0172"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-006-0675-0"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.5c06280","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.5c06280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T09:29:43Z","timestamp":1770715783000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c06280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,2,10]]}},"alternative-id":["10.1021\/acs.analchem.5c06280"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.5c06280","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]}}}