{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:18:41Z","timestamp":1780085921428,"version":"3.54.0"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"15","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2025KLNT203"],"award-info":[{"award-number":["2025KLNT203"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014125","name":"Fujian Provincial Health Commission","doi-asserted-by":"publisher","award":["2025CXA016"],"award-info":[{"award-number":["2025CXA016"]}],"id":[{"id":"10.13039\/501100014125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J01553"],"award-info":[{"award-number":["2024J01553"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903578"],"award-info":[{"award-number":["81903578"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Funds for the Innovation of Science and Technology, Fujian Province, China","award":["2023Y9025"],"award-info":[{"award-number":["2023Y9025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2026,4,21]]},"DOI":"10.1021\/acs.analchem.5c08035","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:56:58Z","timestamp":1775307418000},"page":"11234-11245","source":"Crossref","is-referenced-by-count":1,"title":["Enhanced SNV Detection of\n                    <i>HLA-B*15:02TA<\/i>\n                    by Integrating Blocking RPA and Inhibiting CRISPR-Cas12a"],"prefix":"10.1021","volume":"98","author":[{"given":"Wei-Wei","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pharmacy, National Regional Medical Center","place":["Fuzhou, China"]},{"name":"Binhai Campus of the First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]},{"name":"The First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Regional Medical Center","place":["Fuzhou, China"]},{"name":"Binhai Campus of the First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]},{"name":"The First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Regional Medical Center","place":["Fuzhou, China"]},{"name":"Binhai Campus of the First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]},{"name":"The First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Regional Medical Center","place":["Fuzhou, China"]},{"name":"Binhai Campus of the First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]},{"name":"The First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-9892","authenticated-orcid":true,"given":"Jin-Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Qing","family":"Cai","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Jie","family":"Gan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3491-8859","authenticated-orcid":true,"given":"Zhou-Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Regional Medical Center","place":["Fuzhou, China"]},{"name":"Binhai Campus of the First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]},{"name":"The First Affiliated Hospital, Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010611-134701"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17182"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/428486a"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2021.1946514"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01986-3"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.08.010"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/ismejo\/wraf138"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2420166122"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115248"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c01876"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c05657"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46001-8"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c03338"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-018-0028-z"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0022-x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar6245"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.043"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1192"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00861-x"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52691-x"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43389-7"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf287"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.5c01939"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115936"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2024.117856"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.3c01463"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00594H"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf712"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c05312"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.3c01338"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.132109"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc7802"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c05399"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.3c02485"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1039\/D5CS01006C"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115925"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63094-x"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx2067"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116657"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3390\/foods12020236"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125967"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117529"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.038"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae152"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn392"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2017.12.013"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.120966"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-127069"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.5c08035","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.5c08035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:14:03Z","timestamp":1776759243000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c08035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,4]]},"references-count":48,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,4,21]]}},"alternative-id":["10.1021\/acs.analchem.5c08035"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.5c08035","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,4]]}}}