{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:16:56Z","timestamp":1790986616529,"version":"4.1.0"},"reference-count":23,"publisher":"American Chemical Society (ACS)","issue":"14","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA0913803"],"award-info":[{"award-number":["2023YFA0913803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF0713900"],"award-info":[{"award-number":["2023YFF0713900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1210801"],"award-info":[{"award-number":["2024YFA1210801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21475110"],"award-info":[{"award-number":["21475110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22574134"],"award-info":[{"award-number":["22574134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PCSIRT","award":["IRT_17R66"],"award-info":[{"award-number":["IRT_17R66"]}]},{"name":"NFFTBS","award":["J1310024"],"award-info":[{"award-number":["J1310024"]}]},{"name":"Scientific Research Foundation of State Key Laboratory of Vac-cines for Infectious Diseases, Xiang An Biomedicine Laboratory","award":["2024XAKJ0100005"],"award-info":[{"award-number":["2024XAKJ0100005"]}]},{"name":"Scientific Research Foundation of State Key Laboratory of Vac-cines for Infectious Diseases, Xiang An Biomedicine Laboratory","award":["2025XAKJ0203002"],"award-info":[{"award-number":["2025XAKJ0203002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2026,4,14]]},"DOI":"10.1021\/acs.analchem.6c00149","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T13:45:08Z","timestamp":1774014308000},"page":"10309-10314","source":"Crossref","is-referenced-by-count":3,"title":["Chiral Chromatography Resolution Can Be Enhanced by Using Microfluidic Precision Manufactured Macroporous Silica Microspheres"],"prefix":"10.1021","volume":"98","author":[{"given":"Jikai","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanchen","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichen","family":"An","sequence":"additional","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Wang","sequence":"additional","affiliation":[{"name":"Suzhou Elite Sci. & Tec. Co. Ltd","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6793-6685","authenticated-orcid":true,"given":"Yanling","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4428-3175","authenticated-orcid":true,"given":"Teng-Xiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]},{"name":"Pen-Tung Sah Institute of Micro-Nano Science and Technology","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-0984","authenticated-orcid":true,"given":"Ning","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]},{"name":"Pen-Tung Sah Institute of Micro-Nano Science and Technology","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[{"name":"ColumnScientific, Inc.","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"Suzhou Elite Sci. & Tec. Co. Ltd","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-839X","authenticated-orcid":true,"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/cr8005558"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c11051"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/ja2044453"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12110"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c04755"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/ja00330a057"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)80400-1"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19980504)37:8<1020::AID-ANIE1020>3.0.CO;2-5"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00317"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-636X(1996)8:6<446::AID-CHIR6>3.0.CO;2-A"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1039\/b818553k"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/0927-7757(95)03273-8"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2016.10.025"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2019.109574"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)84568-4"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202418642"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2014.09.006"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.56530\/lcgc.int.th3076t3"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.340563"},{"key":"ref20\/cit20","volume-title":"The Essence of Chromatography","author":"Poole C. F.","year":"2002"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s10570-009-9298-9"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads0790"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c04529"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c00149","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c00149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:14:13Z","timestamp":1776154453000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.6c00149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":23,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,4,14]]}},"alternative-id":["10.1021\/acs.analchem.6c00149"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c00149","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]}}}