{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:47:38Z","timestamp":1790783258466,"version":"4.1.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"15","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2020-06401"],"award-info":[{"award-number":["RGPIN-2020-06401"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22176075"],"award-info":[{"award-number":["22176075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22476072"],"award-info":[{"award-number":["22476072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal. Chem."],"published-print":{"date-parts":[[2026,4,21]]},"DOI":"10.1021\/acs.analchem.6c00265","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T02:44:23Z","timestamp":1775529863000},"page":"11372-11383","source":"Crossref","is-referenced-by-count":3,"title":["Engineering High-Performance Aptamers via Optimized SELEX and Structure-Guided Dimer Assembly for Clinical Malaria Diagnostics"],"prefix":"10.1021","volume":"98","author":[{"given":"Dinghui","family":"Xiong","sequence":"first","affiliation":[{"name":"School of the Environment and Safety Engineering","place":["Zhenjiang, China"]},{"name":"Jiangsu University","place":["Zhenjiang, China"]},{"name":"Department of Biochemistry and Biomedical Sciences","place":["Hamilton, Canada"]},{"name":"McMaster University","place":["Hamilton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyan","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences","place":["Hamilton, Canada"]},{"name":"McMaster University","place":["Hamilton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences","place":["Hamilton, Canada"]},{"name":"McMaster University","place":["Hamilton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Tuberculosis Control","place":["Hangzhou, China"]},{"name":"Zhejiang Center for Disease Control and Prevention","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Dong","sequence":"additional","affiliation":[{"name":"School of the Environment and Safety Engineering","place":["Zhenjiang, China"]},{"name":"Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno J.","family":"Salena","sequence":"additional","affiliation":[{"name":"Department of Medicine","place":["Hamilton, Canada"]},{"name":"McMaster University","place":["Hamilton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4926-347X","authenticated-orcid":true,"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of the Environment and Safety Engineering","place":["Zhenjiang, China"]},{"name":"Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7533-6743","authenticated-orcid":true,"given":"Yingfu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences","place":["Hamilton, Canada"]},{"name":"McMaster University","place":["Hamilton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117152"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2010196117"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2021.130812"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2020.115122"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c05530"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11050768"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14030262"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b01513"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19755-0"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.5b00175"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318665"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC00439B"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24193598"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2020.114020"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b00670"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c03105"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309538110"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2012.03.003"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA03796C"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2017.12.013"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210027"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.7150\/thno.61804"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202514976"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202407049"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09522"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-023-00238-7"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1261\/rna.2161305"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq082"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c11350"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c00848"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-005-0089-3"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2009.04.013"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/ja037832s"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202110819"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201900265"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/mi13030436"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01228-8"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202415226"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133649"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/srep11405"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b02771"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt477"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1112"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09870"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2024.06.029"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54005-4"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1089\/ard.1991.1.141"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf582"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/0960-894X(96)00115-1"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c01136"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00518E"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13615"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2020.112707"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2018.11.140"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.06.006"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC00438A"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c00265","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c00265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:14:11Z","timestamp":1776759251000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.6c00265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":56,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,4,21]]}},"alternative-id":["10.1021\/acs.analchem.6c00265"],"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c00265","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]}}}