{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:41:09Z","timestamp":1792784469598,"version":"4.5.0"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2021GXNSFFA220003"],"award-info":[{"award-number":["2021GXNSFFA220003"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2022GXNSFDA035072"],"award-info":[{"award-number":["2022GXNSFDA035072"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82060647"],"award-info":[{"award-number":["82060647"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82260702"],"award-info":[{"award-number":["82260702"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Guangxi Science and Technology Major Program","award":["GuikeAA24011005"],"award-info":[{"award-number":["GuikeAA24011005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acetylcholinesterase (AChE) plays a crucial role in neuron function and is closely associated with neurodegenerative diseases. Probing AChE-mediated catalytic reactions in biomimetic scenarios (e.g., micro- and nanospace) is of fundamental significance. Here, we present an artificial nanopore to investigate AChE activity by catalyzing acetylcholine (ACh) hydrolysis. In this assay, a predesigned glass nanopore facilitated the electrostatic assembly of the substrate, ACh. Under optimized conditions, AChE exhibited a high catalytic efficiency of up to 94% in a confined environment. The surface charge alteration due to the catalytic reaction was able to regulate ion-gating behavior and ionic current rectification (ICR). In addition, the Michaelis\u2013Menten constant (Km) was calculated to be 26.45 mM, indicating the enhanced catalytic efficiency in the confinement, as compared to that of a conventional macroanalytical system (with a Km of 96.52 mM). The ionic current changes induced by the three enzyme inhibitors (donepezil, huperzine A, and berberine) suggested that donepezil exhibited the most potent inhibitory activity to AChE. Analysis of SH-SY5Y and PC12 cells treated with varying concentrations of the three inhibitors further corroborated their inhibitory capacity. Intriguingly, such biomimetic enzyme kinetic profiling and enzyme\u2013drug interaction assays are currently inaccessible with conventional macro-analysis platforms. The nanopore sensor was successfully used for the detection of AChE activity in blood samples from patients with Alzheimer\u2019s disease. This work should open new avenues for confined enzymatic activity assays and enzyme inhibitor screening.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c01666","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:01:54Z","timestamp":1789981314000},"page":"28704-28716","source":"Crossref","is-referenced-by-count":0,"title":["Probing Acetylcholinesterase\nActivity and Enzyme Inhibitor\nEvaluation by Electrostatic-Gating Nanopores"],"prefix":"10.1021","volume":"98","author":[{"given":"Longda","family":"Li","sequence":"first","affiliation":[{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoquan","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-4183","authenticated-orcid":true,"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6457-8387","authenticated-orcid":true,"given":"Xinchun","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]},{"name":"Guangxi Medical University , , 22 Shuangyong Road , ,","place":["Nanning, China, 530021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7705-4638","authenticated-orcid":true,"given":"Fan","family":"Xia","sequence":"additional","affiliation":[{"name":"China University of Geosciences , , ,","place":["Wuhan, China, 430074"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"38","key":"2026100608080824400_cit1","doi-asserted-by":"publisher","first-page":"25902","DOI":"10.1021\/jacs.4c08450","article-title":"Analyzing Fusion Pore Dynamics and\nCounting the Number of Acetylcholine Molecules Released by Exocytosis","volume":"146","author":"Wang","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"2026100608080824400_cit2","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/s41592-020-0953-2","article-title":"An Optimized Acetylcholine\nSensor\nfor Monitoring in Vivo Cholinergic Activity","volume":"17","author":"Jing","year":"2020","journal-title":"Nat. Methods"},{"issue":"8","key":"2026100608080824400_cit3","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nbt.4184","article-title":"A Genetically Encoded\nFluorescent Acetylcholine Indicator for in Vitro and in Vivo Studies","volume":"36","author":"Jing","year":"2018","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"2026100608080824400_cit4","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","article-title":"Acetylcholine\nas a Neuromodulator:\nCholinergic Signaling Shapes Nervous System Function and Behavior","volume":"76","author":"Picciotto","year":"2012","journal-title":"Neuron"},{"issue":"10510","key":"2026100608080824400_cit5","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/S0140-6736(25)01389-3","article-title":"Alzheimer\u2019s Disease Outlook:\nControversies and Future Directions","volume":"406","author":"Frisoni","year":"2025","journal-title":"Lancet"},{"issue":"24","key":"2026100608080824400_cit6","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1016\/j.scib.2022.12.006","article-title":"Alzheimer\u2019s Disease: Current\nStatus and Perspective","volume":"67","author":"Liu","year":"2022","journal-title":"Sci. Bull."},{"key":"2026100608080824400_cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102309","article-title":"Mechanistic Insights and Emerging Therapeutic Stratagems\nfor Alzheimer\u2019s Disease","volume":"97","author":"Rajendran","year":"2024","journal-title":"Ageing Res.\nRev."},{"key":"2026100608080824400_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115912","article-title":"Nanoplasmonic\nBiosensors for Multicolor\nVisual Analysis of Acetylcholinesterase Activity and Drug Inhibitor\nScreening in Point-of-Care Testing","volume":"247","author":"Li","year":"2024","journal-title":"Biosens.\nBioelectron."},{"issue":"24","key":"2026100608080824400_cit9","doi-asserted-by":"publisher","first-page":"5273","DOI":"10.1111\/bph.15940","article-title":"Donepezil Inhibits Neuromuscular Junctional Acetylcholinesterase\nand Enhances Synaptic Transmission and Function in Isolated Skeletal\nMuscle","volume":"179","author":"Redman","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"2026100608080824400_cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2023.113295","article-title":"Evaluation\nof Berberine Nanoparticles as a Strategy to Modulate Acetylcholinesterase\nActivity","volume":"173","author":"Leimann","year":"2023","journal-title":"Food Res. Int."},{"issue":"11","key":"2026100608080824400_cit11","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.1073\/pnas.1301814110","article-title":"Free Energy Landscape\nfor the Binding Process of Huperzine a to Acetylcholinesterase","volume":"110","author":"Bai","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026100608080824400_cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.159482","article-title":"Novel Colorimetric-Fluorescent\nDual-Mode Biosensing Platform for\nDetecting Acetylcholinesterase and Screening Acetylcholinesterase\nInhibitors Based on Trimetallic Nanozymes","volume":"505","author":"Zheng","year":"2025","journal-title":"Chem.\nEng. J."},{"issue":"15","key":"2026100608080824400_cit13","doi-asserted-by":"publisher","first-page":"8362","DOI":"10.1021\/acs.analchem.4c06917","article-title":"Hydrogen-Bonded\nOrganic Framework Nanozyme with Multi-Enzyme Activity for Chemiluminescence\nSensing of Acetylcholinesterase and Screening Its Inhibitors","volume":"97","author":"Lai","year":"2025","journal-title":"Anal. Chem."},{"key":"2026100608080824400_cit14","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.biopha.2017.10.088","article-title":"Ameliorating Effect of Alpinia Oxyphylla-Schisandra\nChinensis Herb Pair on Cognitive Impairment in a Mouse Model of Alzheimer\u2019s\nDisease","volume":"97","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"23","key":"2026100608080824400_cit15","doi-asserted-by":"publisher","first-page":"12455","DOI":"10.1021\/acs.analchem.5c02343","article-title":"Microwave-Assisted\nRapid Synthesis of near-Infrared Light-Responsive Pd Single-Atom Nanozymes\nfor Colorimetric Detection of Acetylcholinesterase Activity","volume":"97","author":"Ye","year":"2025","journal-title":"Anal. Chem."},{"key":"2026100608080824400_cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123921","article-title":"Preparation and Properties\nof a Dual-Function Cellulose Nanofiber-Based Bionic Biosensor for\nDetecting Silver Ions and Acetylcholinesterase","volume":"403","author":"Wang","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"10","key":"2026100608080824400_cit17","doi-asserted-by":"publisher","first-page":"12134","DOI":"10.1007\/s12274-023-5528-y","article-title":"Aptamer-Induced in-Situ\nGrowth of Acetylcholinesterase-Cu3(PO4)2 Hybrid Nanoflowers for Electrochemical\nDetection of Organophosphorus Inhibitors","volume":"16","author":"Yang","year":"2023","journal-title":"Nano\nRes."},{"issue":"36","key":"2026100608080824400_cit18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2510559122","article-title":"Digital SERS\nBioanalysis\nof Single-Enzyme Biomarkers","volume":"122","author":"Ando","year":"2025","journal-title":"Proc. Natl. Acad.\nSci. U.S.A."},{"issue":"14","key":"2026100608080824400_cit19","doi-asserted-by":"publisher","first-page":"8003","DOI":"10.1039\/D0CS01575J","article-title":"Recent Trends in Biocatalysis","volume":"50","author":"Yi","year":"2021","journal-title":"Chem. Soc. Rev."},{"issue":"9","key":"2026100608080824400_cit20","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41929-018-0117-2","article-title":"Biocatalytic Cascades\nDriven by Enzymes Encapsulated\nin Metal\u2013Organic Framework Nanoparticles","volume":"1","author":"Chen","year":"2018","journal-title":"Nat. Catal."},{"issue":"23","key":"2026100608080824400_cit21","doi-asserted-by":"publisher","first-page":"8110","DOI":"10.1021\/acs.analchem.2c01554","article-title":"Nanoconfined Electrochemical\nCollision and Catalysis\nof Single Enzyme inside Carbon Nanopipettes","volume":"94","author":"Shen","year":"2022","journal-title":"Anal. Chem."},{"issue":"43","key":"2026100608080824400_cit22","doi-asserted-by":"publisher","first-page":"14521","DOI":"10.1021\/acs.analchem.1c03341","article-title":"Nanopipettes for\nthe Electrochemical Study of Enhanced Enzymatic Activity in a Femtoliter\nSpace","volume":"93","author":"Wang","year":"2021","journal-title":"Anal. Chem."},{"issue":"5","key":"2026100608080824400_cit23","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nnano.2016.54","article-title":"Enzymatic\nReactions in Confined Environments","volume":"11","author":"Ku\u0308chler","year":"2016","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"2026100608080824400_cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03030-4","article-title":"Publisher\nCorrection: Role of Outer Surface Probes\nfor Regulating Ion Gating of Nanochannels","volume":"9","author":"Li","year":"2018","journal-title":"Nat.\nCommun."},{"issue":"49","key":"2026100608080824400_cit25","doi-asserted-by":"publisher","first-page":"15216","DOI":"10.1002\/anie.201604405","article-title":"DNA-Based Nanopore\nSensing","volume":"55","author":"Liu","year":"2016","journal-title":"Angew. Chem., Int.\nEd."},{"issue":"49","key":"2026100608080824400_cit26","doi-asserted-by":"publisher","first-page":"25762","DOI":"10.1002\/anie.202111608","article-title":"An Integrated\nPhotoelectrochemical Nanotool for Intracellular Drug Delivery and\nEvaluation of Treatment Effect","volume":"60","author":"Ruan","year":"2021","journal-title":"Angew. Chem.,\nInt. Ed."},{"issue":"1","key":"2026100608080824400_cit27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1021\/acs.chemrev.5c00454","article-title":"Nanopipette Electrochemistry","volume":"126","author":"Chen","year":"2026","journal-title":"Chem. Rev."},{"issue":"16","key":"2026100608080824400_cit28","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.1021\/jacs.7b12106","article-title":"Asymmetric Nanopore Electrode-Based\nAmplification for Electron Transfer Imaging in Live Cells","volume":"140","author":"Ying","year":"2018","journal-title":"J. Am. Chem. Soc."},{"issue":"39","key":"2026100608080824400_cit29","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202406677","article-title":"Electrochemical\nMonitoring of Real-Time Vesicle Dynamics Induced by Tau in a Confined\nNanopipette","volume":"136","author":"Chen","year":"2024","journal-title":"Angew. Chem."},{"issue":"5","key":"2026100608080824400_cit30","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202401448","article-title":"In Situ\nOxygen Generation\nvia a Platinum-Based Wireless Nanopore Electrode for Single-Cell Manipulation","volume":"9","author":"Chen","year":"2025","journal-title":"Small Methods"},{"issue":"41","key":"2026100608080824400_cit31","doi-asserted-by":"publisher","first-page":"28014","DOI":"10.1021\/jacs.4c04934","article-title":"Label-Free Mapping of Multivalent\nBinding Pathways with Ligand-Receptor-Anchored Nanopores","volume":"146","author":"Ma","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"40","key":"2026100608080824400_cit32","doi-asserted-by":"publisher","first-page":"13226","DOI":"10.1002\/anie.201808537","article-title":"Ultrasmall Nanopipette:\nToward Continuous Monitoring of Redox Metabolism at Subcellular Level","volume":"57","author":"Song","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"issue":"48","key":"2026100608080824400_cit33","doi-asserted-by":"publisher","first-page":"15646","DOI":"10.1021\/ja044948v","article-title":"DNA - Nanotube Artificial\nIon Channels","volume":"126","author":"Harrell","year":"2004","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"2026100608080824400_cit34","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.1021\/acs.nanolett.8b01281","article-title":"Highly Sensitive Biosensing with\nSolid-State Nanopores Displaying Enzymatically Reconfigurable Rectification\nProperties","volume":"18","author":"Pe\u0301rez-Mitta","year":"2018","journal-title":"Nano Lett."},{"key":"2026100608080824400_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.159473","article-title":"Photo-Responsive Supramolecular\nHydrogels\nto Enhance Pesticide Bioavailability through Multiple Structural Transformations","volume":"505","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"40","key":"2026100608080824400_cit36","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202509239","article-title":"Cation-Engineered Gradient\nInterfacial Structure toward Dendrite-Free and Shuttle-Free Aqueous\nZn-Iodine Batteries","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."},{"issue":"3","key":"2026100608080824400_cit37","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1021\/acscatal.3c05560","article-title":"Unveiling\nthe Full Dynamical and\nReactivity Profiles of Acetylcholinesterase: A Comprehensive All-Atom\nInvestigation","volume":"14","author":"Ce\u0301lerse","year":"2024","journal-title":"ACS Catal."},{"issue":"1","key":"2026100608080824400_cit38","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41565-025-02052-6","article-title":"Lumen Charge Governs Gated Ion Transport\nin \u03b2-Barrel Nanopores","volume":"21","author":"Mayer","year":"2026","journal-title":"Nat. Nanotechnol."},{"issue":"28","key":"2026100608080824400_cit39","doi-asserted-by":"publisher","first-page":"9902","DOI":"10.1021\/ja505302q","article-title":"DNA-Modified Polymer\nPores Allow pH- and Voltage-Gated Control of Channel Flux","volume":"136","author":"Buchsbaum","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"2026100608080824400_cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2021.116320","article-title":"Recent Advances\nin Colorimetric Strategies for Acetylcholinesterase\nAssay and Their Applications","volume":"142","author":"Liu","year":"2021","journal-title":"TrAC, Trends Anal.\nChem."},{"issue":"1","key":"2026100608080824400_cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41765-x","article-title":"Biomimetic Single Al-OH\nSite with High Acetylcholinesterase-like\nActivity and Self-Defense Ability for Neuroprotection","volume":"14","author":"Xu","year":"2023","journal-title":"Nat. Commun."},{"key":"2026100608080824400_cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116048","article-title":"Structural\nElucidation of a Pectin from Roots of Polygala Tenuifolia and Its\nNeuritogenesis Inducing Activity in PC12 Cells","volume":"236","author":"Zeng","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"26","key":"2026100608080824400_cit43","doi-asserted-by":"publisher","first-page":"8345","DOI":"10.1021\/ja800266p","article-title":"Gating of Single Synthetic Nanopores\nby Proton-Driven DNA Molecular Motors","volume":"130","author":"Xia","year":"2008","journal-title":"J. Am.\nChem. Soc."},{"issue":"12","key":"2026100608080824400_cit44","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1021\/ar400024p","article-title":"Asymmetric Ion Transport through\nIon-Channel-Mimetic Solid-State Nanopores","volume":"46","author":"Guo","year":"2013","journal-title":"Acc.\nChem. Res."},{"issue":"26","key":"2026100608080824400_cit45","doi-asserted-by":"publisher","first-page":"11693","DOI":"10.1021\/jacs.2c03436","article-title":"Rectified and Salt Concentration Dependent Wetting\nof Hydrophobic Nanopores","volume":"144","author":"Polster","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"35","key":"2026100608080824400_cit46","doi-asserted-by":"publisher","first-page":"10850","DOI":"10.1021\/ja047675c","article-title":"Conical-Nanotube\nIon-Current Rectifiers: The Role of Surface Charge","volume":"126","author":"Siwy","year":"2004","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"2026100608080824400_cit47","doi-asserted-by":"publisher","first-page":"3854","DOI":"10.1002\/ange.201512025","article-title":"Effect of\nElectrolyte Concentration\non the Stern Layer Thickness at a Charged Interface","volume":"128","author":"Brown","year":"2016","journal-title":"Angew. 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