{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:13:45Z","timestamp":1786461225954,"version":"build-2736575974"},"reference-count":117,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"Vellore Institute of Technology","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,11]]},"DOI":"10.1021\/acs.analchem.6c02151","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:15:13Z","timestamp":1785849313000},"page":"22570-22585","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive\nReview of Electrochemical Biosensors\nfor the Detection of Breast Cancer through Protein Biomarkers"],"prefix":"10.1021","volume":"98","author":[{"given":"Rehana","family":"K","sequence":"first","affiliation":[{"name":"School of Bio Sciences and Technology, Vellore Institute of Technology , , , ,","place":["Vellore, Tamil Nadu, India, 632014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sithara","family":"Thomas","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Centre at Houston (UTHealth Houston) , , , ,","place":["Houston, Texas, United States, 77030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namo","family":"Dubey","sequence":"additional","affiliation":[{"name":"School of Bio Sciences and Technology, Vellore Institute of Technology , , ,","place":["Vellore, Tamil Nadu, India, 632014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkajyoti","family":"Dutta","sequence":"additional","affiliation":[{"name":"School of Bio Sciences and Technology, Vellore Institute of Technology , , , ,","place":["Vellore, Tamil Nadu, India, 632014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9750-6694","authenticated-orcid":true,"given":"Syama","family":"H P","sequence":"additional","affiliation":[{"name":"School of Bio Sciences and Technology, Vellore Institute of Technology , , , ,","place":["Vellore, Tamil Nadu, India, 632014"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"1","key":"2026081109075231300_cit1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics,\n2023","volume":"73","author":"Siegel","year":"2023","journal-title":"Ca-Cancer J. Clin."},{"key":"2026081109075231300_cit2","unstructured":"American Cancer Society.\n          . Breast Cancer Facts\n& Figures 2023\u201320242024https:\/\/www.cancer.org."},{"key":"2026081109075231300_cit3","unstructured":"World Health Organisation.\n          . Breast cancer2025https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/breast-cancer."},{"issue":"3","key":"2026081109075231300_cit4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1001\/jama.2023.25881","article-title":"Analysis\nof breast cancer\nmortality in the US\u25001975 to 2019","volume":"331","author":"Caswell-Jin","year":"2024","journal-title":"JAMA"},{"issue":"10","key":"2026081109075231300_cit5","doi-asserted-by":"publisher","first-page":"NC09","DOI":"10.7860\/JCDR\/2014\/9237.4971","article-title":"Triple test\nin carcinoma breast","volume":"8","author":"Kharkwal","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"2026081109075231300_cit6","unstructured":"Ko\u0308sters, J. P.; G\u00f8tzsche, P. C.; Cochrane Breast Cancer Group.. Regular self-examination\nor clinical examination for early detection of breast cancerCochrane Database Syst. Rev.199610.1002\/14651858.cd003373."},{"key":"2026081109075231300_cit7","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1002\/cncr.32887","article-title":"Breast cancer early\ndetection: A phased approach to implementation","volume":"126","author":"Ginsburg","year":"2020","journal-title":"Cancer"},{"issue":"19","key":"2026081109075231300_cit8","doi-asserted-by":"publisher","first-page":"10869","DOI":"10.1073\/pnas.191367098","article-title":"Gene expression\npatterns\nof breast carcinomas distinguish tumor subclasses with clinical implications","volume":"98","author":"S\u00f8rlie","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026081109075231300_cit9","unstructured":"FDA\u2013NIH Biomarker Working Group.\n          . BEST\n(Biomarkers, EndpointS, and other Tools) Resource [Internet] Silver\nSpring, MD: U.S. Food and Drug Administration. 2016."},{"key":"2026081109075231300_cit10","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.bios.2016.08.028","article-title":"Biosensors for breast\ncancer diagnosis: A review of bioreceptors, biotransducers and signal\namplification strategies","volume":"88","author":"Mittal","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"2026081109075231300_cit11","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2018.0077","article-title":"Prostate-specific antigen\nglycoprofiling as diagnostic and prognostic biomarker of prostate\ncancer","volume":"9","author":"Tkac","year":"2019","journal-title":"Interface Focus"},{"key":"2026081109075231300_cit12","doi-asserted-by":"publisher","DOI":"10.3389\/fmedt.2024.1360510","article-title":"Multiplex\nelectrochemical\nsensing platforms for the detection of breast cancer biomarkers","volume":"6","author":"O\u2019Brien","year":"2024","journal-title":"Front. Med. Technol."},{"issue":"12","key":"2026081109075231300_cit13","doi-asserted-by":"publisher","first-page":"30011","DOI":"10.3390\/s151229783","article-title":"Microfluidics integrated\nbiosensors: A leading technology towards lab-on-a-chip and sensing\napplications","volume":"15","author":"Luka","year":"2015","journal-title":"Sensors"},{"issue":"2","key":"2026081109075231300_cit14","doi-asserted-by":"publisher","DOI":"10.1140\/epjb\/e2016-60799-9","article-title":"Generalised Drude scattering rate from the memory function formalism:\nan independent verification of the Sharapov-Carbotte result","volume":"89","author":"Bhalla","year":"2016","journal-title":"Eur. Phys. J. B"},{"issue":"4","key":"2026081109075231300_cit15","doi-asserted-by":"publisher","DOI":"10.3390\/s21041109","article-title":"A review on biosensors and recent\ndevelopment of nanostructured materials-enabled\nbiosensors","volume":"21","author":"Naresh","year":"2021","journal-title":"Sensors"},{"issue":"1","key":"2026081109075231300_cit16","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1021\/acs.analchem.1c04475","article-title":"Electrochemical\nbiosensors for the analysis of breast cancer biomarkers:\nfrom design to application","volume":"94","author":"Jing","year":"2022","journal-title":"Anal. Chem."},{"key":"2026081109075231300_cit17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-323-44923-6.00001-7","article-title":"Nanomaterials in biosensors: Fundamentals and applications","volume":"1","author":"Malhotra","year":"2017","journal-title":"Nanomater. Biosens."},{"issue":"3","key":"2026081109075231300_cit18","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.3390\/s80314000","article-title":"Electrochemical biosensors-sensor\nprinciples and architectures","volume":"8","author":"Grieshaber","year":"2008","journal-title":"Sensors"},{"issue":"6\u20137","key":"2026081109075231300_cit19","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0956-5663(01)00313-X","article-title":"Mediated biosensors","volume":"17","author":"Chaubey","year":"2002","journal-title":"Biosens.\nBioelectron."},{"issue":"1\u20132","key":"2026081109075231300_cit20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0009-8981(03)00241-9","article-title":"Biosensors\nin clinical chemistry","volume":"334","author":"D\u2019Orazio","year":"2003","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"2026081109075231300_cit21","doi-asserted-by":"publisher","DOI":"10.1038\/srep01696","article-title":"Direct growth\nof vertically-oriented graphene for field-effect transistor biosensor","volume":"3","author":"Mao","year":"2013","journal-title":"Sci. Rep."},{"issue":"11","key":"2026081109075231300_cit22","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/elan.200390114","article-title":"Probing biomolecular\ninteractions at conductive and\nsemiconductive surfaces by impedance spectroscopy: routes to impedimetric\nimmunosensors, DNA-sensors, and enzyme biosensors","volume":"15","author":"Katz","year":"2003","journal-title":"Electroanalysis"},{"key":"2026081109075231300_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelechem.2020.114573","article-title":"Carbon-based\nnanodots as effective electrochemical sensing tools toward the simultaneous\ndetection of bioactive compounds in complex matrices","volume":"878","author":"Montes","year":"2020","journal-title":"J. Electroanal. Chem."},{"issue":"1","key":"2026081109075231300_cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s44373-025-00027-9","article-title":"Voltammetric\nsensors modified with\nnanomaterials: Applications in rapid detection of bioactive compounds\nfor health and safety monitoring","volume":"2","author":"Harun-Ur-Rashid","year":"2025","journal-title":"Discover Electrochem."},{"key":"2026081109075231300_cit25","doi-asserted-by":"crossref","DOI":"10.1002\/9780470511305","volume-title":"Chemical Sensors and\nBiosensors","author":"Eggins","year":"2002"},{"issue":"5","key":"2026081109075231300_cit26","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1081\/AL-100103209","article-title":"Electrochemical\nbiosensors: recommended definitions and classification","volume":"34","author":"The\u0301venot","year":"2001","journal-title":"Anal. Lett."},{"key":"2026081109075231300_cit27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0003-2670(00)86394-1","article-title":"Multi-analyte miniature conductance\nbiosensor","volume":"231","author":"Cullen","year":"1990","journal-title":"Anal. Chim. Acta"},{"issue":"8\u20139","key":"2026081109075231300_cit28","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/0013-4686(94)E0054-4","article-title":"Conducting\npolymer-based biosensors","volume":"39","author":"Contractor","year":"1994","journal-title":"Electrochim. Acta"},{"key":"2026081109075231300_cit29","first-page":"433","article-title":"Clinical Applications\nof Micro-and Nanoscale Biosensors","volume-title":"Biomedical\nNanostructures","author":"Morrison","year":"2008"},{"issue":"4","key":"2026081109075231300_cit30","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1074\/jbc.274.4.2344","article-title":"Redesigning\nthe substrate specificity of an enzyme by cumulative effects of the\nmutations of non-active site residues","volume":"274","author":"Oue","year":"1999","journal-title":"J. Biol.\nChem."},{"key":"2026081109075231300_cit31","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.snb.2018.02.116","article-title":"In vivo \u201creal-time\u201d\nmonitoring of glucose in the brain with an amperometric enzyme-based\nbiosensor based on gold coated tungsten (W-Au) microelectrodes","volume":"263","author":"Cordeiro","year":"2018","journal-title":"Sens. Actuators, B"},{"issue":"2","key":"2026081109075231300_cit32","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1016\/j.jaci.2009.09.046","article-title":"Structure and function\nof immunoglobulins","volume":"125","author":"Schroeder","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026081109075231300_cit33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1039\/9781788016162-00001","article-title":"Introduction\nto immunosensors","volume-title":"Immunosensors","author":"Lim","year":"2019"},{"key":"2026081109075231300_cit34","doi-asserted-by":"publisher","first-page":"210","DOI":"10.4236\/ajac.2012.33030","article-title":"Biosensors\nfor pesticide detection:\nnew trends","volume":"2012","author":"Audrey","year":"2012","journal-title":"Am. J. Anal. Chem."},{"issue":"24","key":"2026081109075231300_cit35","doi-asserted-by":"publisher","DOI":"10.3390\/s21248491","article-title":"Recent advances in aptasensors for cytokine detection: A review","volume":"21","author":"Kim","year":"2021","journal-title":"Sensors"},{"issue":"1","key":"2026081109075231300_cit36","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s00216-001-1189-3","article-title":"Aptasensors\u2013the\nfuture of biosensing?","volume":"372","author":"O\u2019Sullivan","year":"2002","journal-title":"Anal. Bioanal. Chem."},{"issue":"11","key":"2026081109075231300_cit37","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1039\/c4an00132j","article-title":"Aptamer-based biosensors\nfor biomedical diagnostics","volume":"139","author":"Zhou","year":"2014","journal-title":"Analyst"},{"key":"2026081109075231300_cit38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/B978-0-12-815743-5.00002-0","article-title":"Aptamer Technology\nfor the\nDetection of Foodborne Pathogens and Toxins","volume-title":"Advanced Biosensors for Health Care Applications","author":"Kumar","year":"2019"},{"issue":"7","key":"2026081109075231300_cit39","doi-asserted-by":"publisher","DOI":"10.3390\/s17071623","article-title":"The application\nof whole cell-based biosensors for use in environmental analysis and\nin medical diagnostics","volume":"17","author":"Gui","year":"2017","journal-title":"Sensors"},{"issue":"2","key":"2026081109075231300_cit40","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1021\/acssensors.8b01163","article-title":"Whole-cell biosensor\nwith tunable limit of detection enables low-cost agglutination assays\nfor medical diagnostic applications","volume":"4","author":"Kylilis","year":"2019","journal-title":"ACS Sens."},{"issue":"3","key":"2026081109075231300_cit41","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1021\/acssynbio.9b00448","article-title":"Development of high-performance\nwhole cell biosensors aided by statistical modeling","volume":"9","author":"Berepiki","year":"2020","journal-title":"ACS Synth. Biol."},{"key":"2026081109075231300_cit42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/10_2009_17","article-title":"Electrochemical\nCell-based Sensors","volume-title":"Whole Cell Sensing\nSystems I: Reporter Cells and Devices","author":"Ron","year":"2010"},{"issue":"45","key":"2026081109075231300_cit43","doi-asserted-by":"publisher","first-page":"27194","DOI":"10.1039\/D0RA04736H","article-title":"Cerium oxide nanoparticles:\nproperties, biosynthesis and biomedical application","volume":"10","author":"Singh","year":"2020","journal-title":"RSC Adv."},{"issue":"4","key":"2026081109075231300_cit44","doi-asserted-by":"publisher","DOI":"10.3390\/polym17040545","article-title":"Electrochemical\nBiosensors by Means of Molecularly Imprinted Polymers (MIPs) Cortisol\nRecognition","volume":"17","author":"Nampeng","year":"2025","journal-title":"Polymers"},{"issue":"1","key":"2026081109075231300_cit45","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1021\/acs.analchem.5b03804","article-title":"Applications\nof molecularly imprinted polymer nanoparticles\nand their advances toward industrial use: a review","volume":"88","author":"Wackerlig","year":"2016","journal-title":"Anal. Chem."},{"key":"2026081109075231300_cit46","volume-title":"Carcinoembryonic Antigen","author":"Kankanala","year":"2024"},{"issue":"12","key":"2026081109075231300_cit47","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1002\/1097-0142(19871215)60:123.0.co;2-l","article-title":"Carcinoembryonic antigen\nestimation\nin nipple discharge as an adjunctive tool in the diagnosis of early\nbreast cancer","volume":"60","author":"Inaji","year":"1987","journal-title":"Cancer"},{"issue":"6","key":"2026081109075231300_cit48","doi-asserted-by":"publisher","first-page":"529","DOI":"10.5306\/wjco.v13.i6.529","article-title":"Significance\nof serum carcinoembryonic antigen in metastatic breast cancer patients:\nA prospective study","volume":"13","author":"Anoop","year":"2022","journal-title":"World J. Clin. Oncol."},{"issue":"1","key":"2026081109075231300_cit49","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5529106","article-title":"Association of Preoperative Serum\nLevels of CEA and CA15\u20133 With Molecular Subtypes of Breast\nCancer","volume":"2021","author":"Zhao","year":"2021","journal-title":"Dis. Markers"},{"key":"2026081109075231300_cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2019.111439","article-title":"Gold and silver bio\/nano-hybrids-based\nelectrochemical immunosensor for ultrasensitive detection of carcinoembryonic\nantigen","volume":"141","author":"Nakhjavani","year":"2019","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"2026081109075231300_cit51","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.aca.2010.05.033","article-title":"Nanosilver-doped DNA polyion complex\nmembrane for electrochemical\nimmunoassay of carcinoembryonic antigen using nanogold-labeled secondary\nantibodies","volume":"673","author":"Wu","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"2026081109075231300_cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2023.115234","article-title":"Facile\npreparation of Ru nanoassemblies for electrochemical immunoassay of\ncarcinoembryonic antigen in clinical serum","volume":"676","author":"Sun","year":"2023","journal-title":"Anal. Biochem."},{"issue":"1\u20132","key":"2026081109075231300_cit53","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jelechem.2009.01.016","article-title":"Enhancement of carcinoembryonic\nantibody immobilization on gold electrode modified by gold nanoparticles\nand SiO2\/Thionine nanocomposite","volume":"628","author":"Zhuo","year":"2009","journal-title":"J. Electroanal.\nChem."},{"issue":"1\u20132","key":"2026081109075231300_cit54","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jelechem.2008.10.031","article-title":"Electrochemical\namperometric immunoassay for carcinoembryonic antigen based on bi-layer\nnano-Au and nickel hexacyanoferrates nanoparticles modified glassy\ncarbon electrode","volume":"626","author":"Yuan","year":"2009","journal-title":"J. Electroanal. Chem."},{"key":"2026081109075231300_cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.340455","article-title":"Fabrication of a novel electrochemical immunosensor\nfor the sensitive detection of carcinoembryonic antigen using a double\nsignal attenuation strategy","volume":"1232","author":"Wang","year":"2022","journal-title":"Anal. Chim. Acta"},{"issue":"1","key":"2026081109075231300_cit56","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.aca.2010.03.020","article-title":"An electrochemical\nimmunosensor for carcinoembryonic antigen enhanced by self-assembled\nnanogold coatings on magnetic particles","volume":"665","author":"Li","year":"2010","journal-title":"Anal.\nChim. Acta"},{"issue":"1","key":"2026081109075231300_cit57","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.bios.2012.07.046","article-title":"Bimetallic\nAuPt nanochains: synthesis and their application in electrochemical\nimmunosensor for the detection of carcinoembryonic antigen","volume":"39","author":"Cao","year":"2013","journal-title":"Biosens. Bioelectron."},{"issue":"12","key":"2026081109075231300_cit58","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/nrc2761","article-title":"Mucins\nin cancer: function, prognosis and therapy","volume":"9","author":"Kufe","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"2026081109075231300_cit59","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/0046-8177(95)90146-9","article-title":"Prognostic\nsignificance of MUC1 epithelial mucin expression in breast cancer","volume":"26","author":"McGuckin","year":"1995","journal-title":"Hum. Pathol."},{"issue":"10","key":"2026081109075231300_cit60","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/modpathol.3800445","article-title":"Expression of mucins\n(MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance\nin human breast cancer","volume":"18","author":"Rakha","year":"2005","journal-title":"Mod. Pathol."},{"issue":"7","key":"2026081109075231300_cit61","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1073\/pnas.85.7.2320","article-title":"Isolation\nand sequencing of a cDNA coding for the human DF3 breast carcinoma-associated\nantigen","volume":"85","author":"Siddiqui","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"39","key":"2026081109075231300_cit62","doi-asserted-by":"publisher","first-page":"33374","DOI":"10.1074\/jbc.M506047200","article-title":"The MUC1 SEA module\nis a self-cleaving domain","volume":"280","author":"Levitin","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"22","key":"2026081109075231300_cit63","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1039\/D4TB00454J","article-title":"Precision\nin cancer\ndiagnostics: ultra-sensitive detection of MCF-7 breast cancer cells\nby gold nanostructure-enhanced electrochemical biosensing","volume":"12","author":"Rahmanipour","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"2026081109075231300_cit64","doi-asserted-by":"publisher","first-page":"33606","DOI":"10.1021\/acsami.5c05585","article-title":"Detection with active capture of Breast Cancer marker MUC1 using\nan MXene-based electrochemical actuator","volume":"23","author":"Huang","year":"2025","journal-title":"ACS\nAppl. Mater. Interfaces"},{"key":"2026081109075231300_cit65","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.aca.2019.10.003","article-title":"Competitive\nelectrochemical aptasensor based on a cDNA-ferrocene\/MXene\nprobe for detection of breast cancer marker Mucin1","volume":"1094","author":"Wang","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"2026081109075231300_cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.120369","article-title":"TiO2 nanotubes\/reduced GO nanoparticles for sensitive\ndetection of breast cancer cells and photothermal performance","volume":"208","author":"Safavipour","year":"2020","journal-title":"Talanta"},{"key":"2026081109075231300_cit67","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.2147\/IJN.S127086","article-title":"New generation of electrochemical\nimmunoassay based\non polymeric nanoparticles for early detection of breast cancer","volume":"12","author":"Mouffouk","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"2026081109075231300_cit68","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.aca.2019.11.005","article-title":"An electrochemical aptasensor for analysis of MUC1\nusing gold-platinum bimetallic nanoparticles deposited on carboxylated\ngraphene oxide","volume":"1097","author":"Bharti","year":"2020","journal-title":"Anal. Chim. Acta"},{"issue":"6","key":"2026081109075231300_cit69","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.clbc.2022.04.007","article-title":"Elevated CA\n15.3 in newly diagnosed\nbreast cancer: a retrospective study","volume":"22","author":"Heylen","year":"2022","journal-title":"Clin.\nBreast Cancer"},{"issue":"4","key":"2026081109075231300_cit70","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1177\/172460080001500410","article-title":"CA 15\u20133: a prognostic marker in breast cancer","volume":"15","author":"Duffy","year":"2000","journal-title":"Int. J. Biol. Markers"},{"issue":"7","key":"2026081109075231300_cit71","first-page":"1021","article-title":"Biomarkers in breast cancer [Article in Japanese]","volume":"31","author":"Kurebayashi","year":"2004","journal-title":"Gan to Kagaku Ryoho"},{"issue":"22","key":"2026081109075231300_cit72","doi-asserted-by":"publisher","first-page":"15347","DOI":"10.1039\/D4RA02051K","article-title":"An electrochemically synthesized\nmolecularly imprinted polymer for highly selective detection of breast\ncancer biomarker CA 15\u20133: a promising point-of-care biosensor","volume":"14","author":"Oliveira","year":"2024","journal-title":"RSC Adv."},{"key":"2026081109075231300_cit73","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.bios.2018.03.011","article-title":"Disposable electrochemical\ndetection of breast cancer tumour marker CA 15\u20133 using poly\n(Toluidine Blue) as imprinted polymer receptor","volume":"109","author":"Ribeiro","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"2026081109075231300_cit74","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-017-2532-5","article-title":"Electrochemical\nimmunosensor for\nthe breast cancer marker CA 15\u20133 based on the catalytic activity\nof a CuS\/reduced graphene oxide nanocomposite towards the electrooxidation\nof catechol","volume":"185","author":"Amani","year":"2018","journal-title":"Microchim. Acta"},{"issue":"20","key":"2026081109075231300_cit75","doi-asserted-by":"publisher","first-page":"25601","DOI":"10.1021\/acsami.3c15531","article-title":"Electrochemical\nDetection of a Breast Cancer Biomarker with an Amine-Functionalized\nNanocomposite Pt\u2013Fe3O4\u2013MWCNTs\u2013NH2 as a Signal-Amplifying\nLabel","volume":"16","author":"Patil","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"7","key":"2026081109075231300_cit76","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-024-06448-4","article-title":"Atomically Co-dispersed nitrogen-doped carbon for sensitive\nelectrochemical immunoassay of breast cancer biomarker CA15\u20133","volume":"191","author":"Han","year":"2024","journal-title":"Microchim. Acta"},{"key":"2026081109075231300_cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2025.127746","article-title":"CA 15\u20133-specific\nmolecularly imprinted polymer nanoparticles-based voltammetric sensor\nfor breast cancer monitoring","volume":"288","author":"Akkapinyo","year":"2025","journal-title":"Talanta"},{"issue":"11","key":"2026081109075231300_cit78","doi-asserted-by":"publisher","DOI":"10.3390\/bios12110921","article-title":"Construction\nof aptamer-based nanobiosensor for breast cancer biomarkers detection\nutilizing g-C3N4\/magnetic nano-structure","volume":"12","author":"Pourmadadi","year":"2022","journal-title":"Biosensors"},{"issue":"3","key":"2026081109075231300_cit79","doi-asserted-by":"publisher","DOI":"10.3390\/bios13030317","article-title":"Dual-mode sensing platform\nfor cancer antigen 15\u20133 determination based on a silica nanochannel\narray using electrochemiluminescence and electrochemistry","volume":"13","author":"Huang","year":"2023","journal-title":"Biosensors"},{"issue":"1","key":"2026081109075231300_cit80","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-78836-y","article-title":"Highly efficient electrochemical biosensing platform\nin breast cancer detection based on MOF-COF@ Au core-shell like nanostructure","volume":"14","author":"Dezhakam","year":"2024","journal-title":"Sci. Rep."},{"issue":"2","key":"2026081109075231300_cit81","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/PAP.0000000000000015","article-title":"HER2 in breast cancer: a review and update","volume":"21","author":"Krishnamurti","year":"2014","journal-title":"Adv. Anat. Pathol."},{"issue":"2","key":"2026081109075231300_cit82","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ctrv.2011.03.008","article-title":"HER2 shedding and\nserum HER2 extracellular domain: biology and clinical utility in breast\ncancer","volume":"38","author":"Tse\u0301","year":"2012","journal-title":"Cancer Treat. Rev."},{"issue":"12","key":"2026081109075231300_cit83","doi-asserted-by":"publisher","first-page":"5570","DOI":"10.1128\/mcb.8.12.5570-5574.1988","article-title":"Different\nstructural alterations upregulate in vitro tyrosine kinase activity\nand transforming potency of the erbB-2 gene","volume":"8","author":"Segatto","year":"1988","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"2026081109075231300_cit84","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-03035-w","article-title":"Accurate HER2 determination\nin breast cancer: a prominent COF-immobilized\nenzyme-enhanced electrochemical aptasensor employing 4-acetamidophenol\nas an efficient mediator","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"38","key":"2026081109075231300_cit85","doi-asserted-by":"publisher","first-page":"34177","DOI":"10.1021\/acsomega.2c03532","article-title":"Morphology-tuned\nelectrochemical immunosensing of a breast cancer biomarker using hierarchical\npalladium nanostructured interfaces","volume":"7","author":"Joshi","year":"2022","journal-title":"ACS Omega"},{"key":"2026081109075231300_cit86","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2023.108589","article-title":"Nitrogen-enhanced\ncarbon quantum dots mediated immunosensor\nfor electrochemical detection of HER2 breast cancer biomarker","volume":"155","author":"Amir","year":"2024","journal-title":"Bioelectrochemistry"},{"key":"2026081109075231300_cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117030","article-title":"Employing Pd nanoparticles\ndecorated on halloysite nanotube\/carbon composite for electrochemical\naptasensing of HER2 in breast cancer patients","volume":"237","author":"Bi","year":"2023","journal-title":"Environ. Res."},{"issue":"25","key":"2026081109075231300_cit88","doi-asserted-by":"publisher","first-page":"6667","DOI":"10.1007\/s00216-019-02040-5","article-title":"Electrochemical\naptasensor for the detection of HER2 in human serum to assist in the\ndiagnosis of early-stage breast cancer","volume":"411","author":"Bezerra","year":"2019","journal-title":"Anal.\nBioanal. Chem."},{"key":"2026081109075231300_cit89","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2024.126130","article-title":"A ratiometric electrochemical\nbiosensor based on ARGET ATRP for detection\nof HER2 gene","volume":"275","author":"Feng","year":"2024","journal-title":"Talanta"},{"key":"2026081109075231300_cit90","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.113118","article-title":"An ultrasensitive\ndual-signal ratio electrochemical\naptamer biosensor for the detection of HER2","volume":"222","author":"Zhang","year":"2023","journal-title":"Colloids Surf., B"},{"issue":"21","key":"2026081109075231300_cit91","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.1039\/c3tb21699c","article-title":"Graphene oxide reduced directly by\nredox probes for multiplexed detection of tumor markers","volume":"2","author":"Liu","year":"2014","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"2026081109075231300_cit92","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1039\/C1AN15698E","article-title":"Sensitive\nelectrochemical immunosensor array for the simultaneous detection\nof multiple tumor markers","volume":"137","author":"Qi","year":"2012","journal-title":"Analyst"},{"key":"2026081109075231300_cit93","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.aca.2020.07.021","article-title":"Multiplexed label-free\nelectrochemical immunosensor for breast cancer precision medicine","volume":"1130","author":"Cotchim","year":"2020","journal-title":"Anal. Chim. Acta"},{"issue":"33","key":"2026081109075231300_cit94","doi-asserted-by":"publisher","first-page":"13690","DOI":"10.1021\/acs.analchem.4c02674","article-title":"Potential-resolved\nratio electrochemiluminescence biosensor based on perylene diimide-MOF\nand DNA nanoflowers\u2013CdS quantum dots for detection of dual\ntargets","volume":"96","author":"Zhang","year":"2024","journal-title":"Anal. Chem."},{"key":"2026081109075231300_cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112260","article-title":"A gold nanoparticle-dye\/poly\n(3-aminobenzylamine)\/two-dimensional MoSe2\/graphene oxide electrode\ntowards label-free electrochemical biosensor for simultaneous dual-mode\ndetection of cancer antigen 15\u20133 and microRNA-21","volume":"210","author":"Pothipor","year":"2022","journal-title":"Colloids Surf., B"},{"issue":"33","key":"2026081109075231300_cit96","doi-asserted-by":"publisher","first-page":"6576","DOI":"10.1039\/D1TB00940K","article-title":"A label-free\nmultiplex electrochemical\nbiosensor for the detection of three breast cancer biomarker proteins\nemploying dye\/metal ion-loaded and antibody-conjugated polyethyleneimine-gold\nnanoparticles","volume":"9","author":"Kuntamung","year":"2021","journal-title":"J. Mater. Chem. B"},{"issue":"9","key":"2026081109075231300_cit97","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-018-2918-z","article-title":"Dual-aptamer-based electrochemical sandwich biosensor\nfor MCF-7 human breast cancer cells using silver nanoparticle labels\nand a poly(glutamic acid)\/MWNT nanocomposite","volume":"185","author":"Yazdanparast","year":"2018","journal-title":"Microchim. Acta"},{"key":"2026081109075231300_cit98","doi-asserted-by":"publisher","first-page":"5743","DOI":"10.1021\/acsabm.5c00452","article-title":"Using Ru-PdO@ MXenes-Nanostructured\nElectrochemical Immunosensing System for Selective Detection of Multiple\nBreast Biomarkers (HER2 and MUC1)","volume":"8","author":"Sawy","year":"2025","journal-title":"ACS Appl.\nBio Mater."},{"issue":"16","key":"2026081109075231300_cit99","doi-asserted-by":"publisher","first-page":"9001","DOI":"10.1021\/acs.chemrev.6b00220","article-title":"Electrochemical methods for the analysis\nof clinically relevant biomolecules","volume":"116","author":"Labib","year":"2016","journal-title":"Chem. Rev."},{"key":"2026081109075231300_cit100","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.bios.2015.08.037","article-title":"Biosensors and bioelectronics on\nsmartphone for portable biochemical detection","volume":"75","author":"Zhang","year":"2016","journal-title":"Biosens. Bioelectron."},{"issue":"7101","key":"2026081109075231300_cit101","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nature05058","article-title":"The origins and the future of microfluidics","volume":"442","author":"Whitesides","year":"2006","journal-title":"Nature"},{"key":"2026081109075231300_cit102","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.bios.2015.08.037","article-title":"Biosensors and Bioelectronics\non\nsmartphone for portable biochemical detection","volume":"75","author":"Zhang","year":"2016","journal-title":"Biosens. Bioelectron."},{"issue":"12","key":"2026081109075231300_cit103","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-025-07523-0","article-title":"Smartphone-based\nbiosensing: a review of optical imaging, microfluidic integration,\nand AI-enhanced analysis","volume":"192","author":"Avci","year":"2025","journal-title":"Microchim. Acta"},{"issue":"11","key":"2026081109075231300_cit104","doi-asserted-by":"publisher","first-page":"5304","DOI":"10.1021\/ac401058v","article-title":"Multiplexed electrochemical protein\ndetection and translation\nto personalized cancer diagnostics","volume":"85","author":"Rusling","year":"2013","journal-title":"Anal. Chem."},{"issue":"4","key":"2026081109075231300_cit105","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s41587-019-0045-y","article-title":"Wearable biosensors\nfor healthcare monitoring","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"2026081109075231300_cit106","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1373\/clinchem.2008.105601","article-title":"National\nAcademy of Clinical Biochemistry laboratory medicine practice guidelines\nfor use of tumor markers in testicular, prostate, colorectal, breast,\nand ovarian cancers","volume":"54","author":"Sturgeon","year":"2008","journal-title":"Clin. Chem."},{"issue":"1","key":"2026081109075231300_cit107","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-019-1014-6","article-title":"A new concordant\npartial AUC and partial c statistic for imbalanced data in the evaluation\nof machine learning algorithms","volume":"20","author":"Carrington","year":"2020","journal-title":"BMC Med. Inf.\nDecis. Making"},{"key":"2026081109075231300_cit108","doi-asserted-by":"publisher","DOI":"10.1016\/j.coelec.2025.101776","article-title":"Electrochemical\nbiosensors: A prospective\ninsight to recent developments and future directions","volume":"54","author":"Goswami","year":"2025","journal-title":"Curr. Opin. Electrochem."},{"issue":"4","key":"2026081109075231300_cit109","doi-asserted-by":"publisher","DOI":"10.3390\/s21041109","article-title":"A review on biosensors\nand recent\ndevelopment of nanostructured materials enabled biosensors","volume":"21","author":"Naresh","year":"2021","journal-title":"Sensors"},{"issue":"2","key":"2026081109075231300_cit110","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020423","article-title":"Antifouling (bio) materials for electrochemical (bio)\nsensing","volume":"20","author":"Campuzano","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"2026081109075231300_cit111","doi-asserted-by":"publisher","first-page":"4572","DOI":"10.1021\/acsomega.3c07660","article-title":"Methods of\nprotection of electrochemical sensors against biofouling in cell culture\napplications","volume":"9","author":"Jarosin\u0301ska","year":"2024","journal-title":"ACS Omega"},{"issue":"8","key":"2026081109075231300_cit112","doi-asserted-by":"publisher","first-page":"315","DOI":"10.22270\/jddt.v15i8.7171","article-title":"Advancements,\nChallenges,\nand Future Directions in Biosensor Technology for Healthcare and Diagnostics","volume":"15","author":"Bhaskar","year":"2025","journal-title":"J. Drug Delivery Ther."},{"issue":"71","key":"2026081109075231300_cit113","doi-asserted-by":"publisher","first-page":"13359","DOI":"10.1039\/D5CC02322J","article-title":"Maximising\nthe translation potential of electrochemical biosensors","volume":"61","author":"Docherty","year":"2025","journal-title":"Chem. Commun."},{"key":"2026081109075231300_cit114","doi-asserted-by":"publisher","DOI":"10.1016\/j.coelec.2025.101745","article-title":"Implantable electrochemical\nbiosensors: Challenges, strategies, and applications","volume":"54","author":"Ben-Aissa","year":"2025","journal-title":"Curr. Opin. Electrochem."},{"issue":"10","key":"2026081109075231300_cit115","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26102940","article-title":"Electrochemical biosensors in food\nsafety: challenges\nand perspectives","volume":"26","author":"Curulli","year":"2021","journal-title":"Molecules"},{"issue":"11","key":"2026081109075231300_cit116","doi-asserted-by":"publisher","first-page":"8480","DOI":"10.1039\/D4RA08220F","article-title":"Recent advances of silver nanoparticle-based\npolymer\nnanocomposites for biomedical applications","volume":"15","author":"Harun-Ur-Rashid","year":"2025","journal-title":"RSC Adv."},{"key":"2026081109075231300_cit117","volume-title":"Advanced\nBiosensors for Health Care Applications","author":"Khan","year":"2019"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c02151","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/31\/22570\/66323335\/acs.analchem.6c02151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/31\/22570\/66323335\/acs.analchem.6c02151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T13:17:06Z","timestamp":1786454226000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/31\/22570\/5236319\/A-Comprehensive-Review-of-Electrochemical"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":117,"journal-issue":{"issue":"31","published-online":{"date-parts":[[2026,7,28]]},"published-print":{"date-parts":[[2026,8,11]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c02151","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}