{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:25:18Z","timestamp":1787063118012,"version":"build-2736575974"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"The State key program of Guangxi Natural Science Foundation Program","award":["2021JJD170019"],"award-info":[{"award-number":["2021JJD170019"]}]},{"name":"Capacity Building of Guangxi Key Laboratory of Automatic Detecting Technology and Instruments","award":["GuiKeLT2600640021"],"award-info":[{"award-number":["GuiKeLT2600640021"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["62564003"],"award-info":[{"award-number":["62564003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study designs and constructs a dielectric barrier discharge (DBD)\u2013field asymmetric ion mobility spectrometry (FAIMS) system. An innovative approach is adopted to fabricate a multi-channel DBD ion source using 3D printing technology. The printing material itself served as the discharge medium, enabling the simultaneous generation of four plasma jets, effectively enhancing the ionization efficiency. By optimizing the inlet positions of nitrogen and helium gases, the background ion signal intensity was reduced from 356.3 pA to 0, effectively eliminating the system background noise. Under the optimal working conditions, namely when the four-stream ion source operates at a helium gas flow rate of 0.5 L\/min, a discharge voltage of \u22125.1 kV, and a nitrogen gas flow rate of 1.2 L\/min, the detection sensitivity of FAIMS was significantly improved compared to the single-stream source. The nonlinear coefficient \u03b1 curve characteristics of the FAIMS spectrum were utilized to distinguish different samples. As a validation of the application prospect, exhaled gas samples from diabetic patients and healthy volunteers were collected and analyzed. The results showed that the characteristic signal intensity of acetone in the exhaled gas of diabetic patients was higher than that of healthy controls, and when the blood glucose level was 2.5 mmol\/L higher, the signal intensity was approximately 0.25 times higher. This preliminary study proves the potential of this system in non-invasive screening of diabetes.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c02170","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:02:20Z","timestamp":1785934940000},"page":"23613-23621","source":"Crossref","is-referenced-by-count":0,"title":["Research on\nthe FAIMS System Based on Multijet DBD\nIon Source and Background Noise Suppression"],"prefix":"10.1021","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8647-2950","authenticated-orcid":true,"given":"Xiaoxia","family":"Du","sequence":"first","affiliation":[{"name":"Guilin University of Electronic Technology , , ,","place":["Guilin, Guangxi, China, 541004"]},{"name":"Guilin University of Electronic Technology , , ,","place":["Guilin, Guangxi, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanglong","family":"Wang","sequence":"additional","affiliation":[{"name":"Guilin University of Electronic Technology , , ,","place":["Guilin, Guangxi, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Guilin University of Electronic Technology , , ,","place":["Guilin, Guangxi, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Guilin University of Electronic Technology , , ,","place":["Guilin, Guangxi, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Li","sequence":"additional","affiliation":[{"name":"Guilin University of Electronic Technology , , ,","place":["Guilin, Guangxi, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankun","family":"Shi","sequence":"additional","affiliation":[{"name":"Guilin University of Electronic Technology , , ,","place":["Guilin, Guangxi, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3483-9392","authenticated-orcid":true,"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Guilin University of Electronic Technology , , ,","place":["Guilin, Guangxi, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"issue":"12","key":"2026081809083599800_cit1","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1134\/S1061934824701430","article-title":"Rapid Detection of Acetone in Exhaled\nBreath for the Diagnosis of Diabetes Mellitus","volume":"79","author":"Platonov","year":"2024","journal-title":"J. Anal. Chem."},{"issue":"10","key":"2026081809083599800_cit2","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1073\/pnas.68.10.2374","article-title":"Quantitative analysis\nof urine vapor and breath by gas-liquid partition chromatography","volume":"68","author":"Pauling","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"8","key":"2026081809083599800_cit3","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1093\/clinchem\/31.8.1278","article-title":"Volatile\norganic compounds in exhaled air from patients with lung cancer","volume":"31","author":"Gordon","year":"1985","journal-title":"Clin. Chem."},{"issue":"1","key":"2026081809083599800_cit4","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.9211","article-title":"Application\nof zero-phase digital filtering for effective denoising of field asymmetric\nwaveform ion mobility spectrometry signal","volume":"36","author":"Li","year":"2022","journal-title":"Rapid\nCommun. Mass Spectrom."},{"issue":"2","key":"2026081809083599800_cit5","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.talanta.2008.12.012","article-title":"Effect of UV irradiation on detection of cocaine hydrochloride\nand crack vapors by IMIS and API-MS methods","volume":"78","author":"Kolomiets","year":"2009","journal-title":"Talanta"},{"key":"2026081809083599800_cit6","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.talanta.2018.04.035","article-title":"Ion mobility spectrometer with orthogonal X-Ray source\nfor increased sensitivity","volume":"185","author":"Bunert","year":"2018","journal-title":"Talanta"},{"issue":"5","key":"2026081809083599800_cit7","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1007\/s11090-019-10006-9","article-title":"Kinetic Modelling\nof Atmospheric\nPressure Corona Discharges in Humid Air","volume":"39","author":"Wang","year":"2019","journal-title":"Plasma\nChem. Plasma Process."},{"issue":"3\u20134","key":"2026081809083599800_cit8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1080\/03067318808081669","article-title":"Quantitative Assessment\nof a Corona Discharge Ion Source in Atmospheric Pressure Ionization-Mass\nSpectrometry for Ambient Air Monitoring","volume":"33","author":"Eiceman","year":"1988","journal-title":"Int.\nJ. Environ. Anal. Chem."},{"issue":"2","key":"2026081809083599800_cit9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/mas.21914","article-title":"Ion Chemistry\nin Dielectric\nBarrier Discharge Ionization: Recent Advances in Direct Gas Phase\nAnalyses","volume":"45","author":"Dryahina","year":"2026","journal-title":"Mass Spectrom. Rev."},{"key":"2026081809083599800_cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2023.125204","article-title":"Dual ionization sources\nhigh-field asymmetric waveform ion mobility\nspectrometry with combined ultraviolet lamp source and corona discharge\nsource","volume":"267","author":"Jin","year":"2024","journal-title":"Talanta"},{"issue":"1\u20132","key":"2026081809083599800_cit11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0021-9673(04)01478-5","article-title":"High-field\nasymmetric waveform ion mobility spectrometry: A new tool for mass\nspectrometry","volume":"1058","author":"Guevremont","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"2026081809083599800_cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2022.116970","article-title":"Analysis of liquid samples by Low-Temperature\nPlasma Ionization Source-ion mobility spectrometry","volume":"483","author":"Ismaili","year":"2023","journal-title":"Int. J. Mass Spectrom."},{"issue":"17","key":"2026081809083599800_cit13","doi-asserted-by":"publisher","first-page":"8932","DOI":"10.1021\/acs.analchem.5b02077","article-title":"Low-temperature plasma ionization\ndifferential ion\nmobility spectrometry","volume":"87","author":"Kuklya","year":"2015","journal-title":"Anal. Chem."},{"issue":"3","key":"2026081809083599800_cit14","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1109\/TPS.2021.3057417","article-title":"Mass Spectrometry Study on Ions Generated by Low-Temperature Plasma\nJet","volume":"49","author":"Chen","year":"2021","journal-title":"IEEE Trans. Plasma Sci."},{"issue":"16","key":"2026081809083599800_cit15","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1016\/j.chroma.2009.12.042","article-title":"Sorbent-based\nsampling methods for volatile and semi-volatile organic compounds\nin air: Part 1: Sorbent-based air monitoring options","volume":"1217","author":"Woolfenden","year":"2010","journal-title":"J. Chromatogr. A"},{"issue":"6","key":"2026081809083599800_cit16","first-page":"707","article-title":"Research progress on collection and\nanalysis methods\nof exhaled volatile organic compounds","volume":"41","author":"Yazhen","year":"2024","journal-title":"Environ.\nOccup. Med."},{"issue":"17","key":"2026081809083599800_cit17","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1080\/00032719.2023.2185784","article-title":"Integrated\nLithium Battery-Powered High-Field Asymmetric Ion Mobility Spectrometer\n(FAIMS) for Molecular Structure Fingerprinting and Deep Learning","volume":"56","author":"Tingting","year":"2023","journal-title":"Anal. Lett."},{"issue":"18","key":"2026081809083599800_cit18","doi-asserted-by":"publisher","first-page":"7649","DOI":"10.1021\/ac101413k","article-title":"High-Resolution\nDifferential Ion Mobility Separations Using Planar Analyzers at Elevated\nDispersion Fields","volume":"82","author":"Shvartsburg","year":"2010","journal-title":"Anal. Chem."},{"issue":"2","key":"2026081809083599800_cit19","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1006\/abio.1997.2069","article-title":"Method for\nthe collection and Assay of Volatile organic Compounds in Breath","volume":"247","author":"Phillips","year":"1997","journal-title":"Anal. Biochem."},{"issue":"2","key":"2026081809083599800_cit20","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1006\/abio.1997.2069","article-title":"Method for\nthe Collection and assay of volatile Organic Compounds in breath","volume":"247","author":"Phillips","year":"1997","journal-title":"Anal. Biochem."},{"key":"2026081809083599800_cit21","first-page":"2713","article-title":"Study on the\nEffect of He-N-2 Ratio in Mixed Carrier Gas on Separation of VOC Aliasing\nPeaks in FAIMS","volume":"39","author":"Hai-Xia","year":"2019","journal-title":"Spectrosc. Spectral Anal."},{"issue":"21","key":"2026081809083599800_cit22","doi-asserted-by":"publisher","first-page":"8749","DOI":"10.1021\/ac900880v","article-title":"Simulation of ion motion in FAIMS\nthrough combined\nuse of SIMION and modified SDS","volume":"81","author":"Prasad","year":"2009","journal-title":"Anal. Chem."},{"key":"2026081809083599800_cit23","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ijms.2019.04.008","article-title":"Characterization\nof ion transmission in UV-FAIMS by incorporating ion recombination","volume":"442","author":"Wang","year":"2019","journal-title":"Int. J. Mass Spectrom."},{"key":"2026081809083599800_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2023.117115","article-title":"Reducing ion diffusion\nat atmospheric\npressure through intermingled positive and negative ions","volume":"492","author":"Ewing","year":"2023","journal-title":"Int. J. Mass Spectrom."},{"issue":"10","key":"2026081809083599800_cit25","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1021\/jasms.4c00427","article-title":"Experiment and Simulation Study of Automatic Temperature Control\nFAIMS Chip","volume":"36","author":"Du","year":"2025","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"12","key":"2026081809083599800_cit26","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1063\/1.1149255","article-title":"Mass spectrometric\ncharacterization of a high-field asymmetric waveform ion mobility\nspectrometer","volume":"69","author":"Purves","year":"1998","journal-title":"Rev. Sci. Instrum."}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c02170","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/32\/23613\/66378452\/acs.analchem.6c02170.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/32\/23613\/66378452\/acs.analchem.6c02170.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:31:35Z","timestamp":1787059895000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/32\/23613\/5242142\/Research-on-the-FAIMS-System-Based-on-Multijet-DBD"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":26,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2026,8,3]]},"published-print":{"date-parts":[[2026,8,18]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c02170","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]}}}