{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:42:08Z","timestamp":1792784528810,"version":"4.5.0"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012452","name":"Chengdu Municipal Institute of Biology, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["E4S319"],"award-info":[{"award-number":["E4S319"]}],"id":[{"id":"10.13039\/501100012452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2026NSFSC0873"],"award-info":[{"award-number":["2026NSFSC0873"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["2022YFS0511"],"award-info":[{"award-number":["2022YFS0511"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22504139"],"award-info":[{"award-number":["22504139"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mass spectrometry imaging enables the spatially resolved analysis of molecular distributions in biological tissues. However, in situ untargeted metabolite identification remains challenging due to the inherent trade-off between spatial resolution and in situ tandem mass spectrometry (MS2) acquisition. Here, we developed clustering resampling mass spectrometry imaging (CR-MSI), a method that innovatively converts in situ MS2 acquisition from countless pixel scans to a few representative points testing. CR-MSI allows the acquisition of both spatial localization and structural fragmentation data for metabolites from a single tissue section. Additionally, we have engineered an integrated device that automates the CR-MSI workflow, transforming MS2 acquisition from an empirical, operator-dependent procedure to an objective, data-driven process. Moreover, the synchronization between MSI data acquisition and processing has improved the efficiency and overall MSI throughput. When applied to rat brain, CR-MSI collected 1,175 MS2 species, representing a 410% increase compared with conventional techniques. This approach will vastly enhance the structural elucidation of untargeted mass spectrometry imaging.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c02449","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:02:01Z","timestamp":1789621321000},"page":"28006-28016","source":"Crossref","is-referenced-by-count":0,"title":["<i>InSitu<\/i>\n                    Untargeted Metabolite Identification\nand Spatial Mapping by Clustering Resampling Mass Spectrometry Imaging"],"prefix":"10.1021","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-4331","authenticated-orcid":true,"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences , ,","place":["Chengdu, China, 610213"]},{"name":"State Administration for Market Regulation , , ,","place":["Chengdu, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoting","family":"Shi","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences , ,","place":["Chengdu, China, 610213"]},{"name":"State Administration for Market Regulation , , ,","place":["Chengdu, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Liu","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences , ,","place":["Chengdu, China, 610213"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 101408"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ye","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences , ,","place":["Chengdu, China, 610213"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 101408"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuolin","family":"Jin","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences , ,","place":["Chengdu, China, 610213"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 101408"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Gu","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences , ,","place":["Chengdu, China, 610213"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 101408"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences , ,","place":["Chengdu, China, 610213"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 101408"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ran","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences , ,","place":["Chengdu, China, 610213"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-1866","authenticated-orcid":true,"given":"Wenlin","family":"Wu","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Food Inspection , ,","place":["Chengdu, P. R. China, 611130"]},{"name":"State Administration for Market Regulation , , ,","place":["Beijing, China, 100029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-3095","authenticated-orcid":true,"given":"Bing","family":"Xia","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences , ,","place":["Chengdu, China, 610213"]},{"name":"State Administration for Market Regulation , , ,","place":["Chengdu, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3015-724X","authenticated-orcid":true,"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences , ,","place":["Chengdu, China, 610213"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 101408"]},{"name":"State Administration for Market Regulation , , ,","place":["Chengdu, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"29","key":"2026092909103788000_cit1","doi-asserted-by":"publisher","first-page":"15517","DOI":"10.1021\/acs.analchem.4c05249","article-title":"Mass Spectrometry Imaging","volume":"97","author":"Ko\u0308rber","year":"2025","journal-title":"Anal. Chem."},{"issue":"5767","key":"2026092909103788000_cit2","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1126\/science.1119426","article-title":"Ambient Mass Spectrometry","volume":"311","author":"Cooks","year":"2006","journal-title":"Science"},{"key":"2026092909103788000_cit3","doi-asserted-by":"publisher","first-page":"117055","DOI":"10.1016\/j.trac.2023.117055","article-title":"High-Throughput Mass\nSpectrometry Imaging of Biological Systems: Current Approaches and\nFuture Directions","volume":"163","author":"Jiang","year":"2023","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"9","key":"2026092909103788000_cit4","doi-asserted-by":"publisher","first-page":"100576","DOI":"10.1016\/j.mcpro.2023.100576","article-title":"Prospective on Imaging\nMass Spectrometry in Clinical Diagnostics","volume":"22","author":"Moore","year":"2023","journal-title":"Mol.\nCell. Proteomics"},{"key":"2026092909103788000_cit5","doi-asserted-by":"publisher","first-page":"115080","DOI":"10.1016\/j.bcp.2022.115080","article-title":"Spatial Analysis\nof Drug Absorption, Distribution, Metabolism, and Toxicology Using\nMass Spectrometry Imaging","volume":"201","author":"Spruill","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"21","key":"2026092909103788000_cit6","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.4155\/bio.11.232","article-title":"MALDI Imaging Mass Spectrometry:\nBridging Biology and Chemistry in Drug Development","volume":"3","author":"Castellino","year":"2011","journal-title":"Bioanalysis"},{"issue":"1","key":"2026092909103788000_cit7","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s00216-011-4990-7","article-title":"Mass Spectrometry Imaging\nwith High Resolution in Mass and Space (HR2MSI) for Reliable Investigation\nof Drug Compound Distributions on the Cellular Level","volume":"401","author":"Ro\u0308mpp","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"issue":"14","key":"2026092909103788000_cit8","doi-asserted-by":"publisher","first-page":"5648","DOI":"10.1021\/ac800617s","article-title":"MALDI-FTICR\nImaging Mass Spectrometry\nof Drugs and Metabolites in Tissue","volume":"80","author":"Cornett","year":"2008","journal-title":"Anal. Chem."},{"issue":"2","key":"2026092909103788000_cit9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00418-013-1127-4","article-title":"Qualitative and Quantitative\nMass Spectrometry Imaging of Drugs and\nMetabolites in Tissue at Therapeutic Levels","volume":"140","author":"Sun","year":"2013","journal-title":"Histochem. Cell Biol."},{"issue":"6","key":"2026092909103788000_cit10","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1002\/rcm.2397","article-title":"Matrix-Assisted\nLaser Desorption\/Ionization Imaging Mass Spectrometry for Direct Measurement\nof Clozapine in Rat Brain Tissue","volume":"20","author":"Hsieh","year":"2006","journal-title":"Rapid Commun.\nMass Spectrom."},{"issue":"6","key":"2026092909103788000_cit11","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1002\/rcm.3934","article-title":"Matrix-Assisted Laser Desorption\/Ionization\nMass Spectrometric Imaging of Complete Rat Sections Using a Triple\nQuadrupole Linear Ion Trap","volume":"23","author":"Hopfgartner","year":"2009","journal-title":"Rapid Commun. Mass\nSpectrom."},{"issue":"10","key":"2026092909103788000_cit12","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1002\/jms.525","article-title":"Direct Analysis of Drug Candidates in Tissue by Matrix-Assisted\nLaser Desorption\/Ionization Mass Spectrometry","volume":"38","author":"Reyzer","year":"2003","journal-title":"J. Mass Spectrom."},{"issue":"6","key":"2026092909103788000_cit13","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1021\/ac1029049","article-title":"High-Sensitivity MALDI-MRM-MS\nImaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit\nLungs and Granulomatous Lesions","volume":"83","author":"Prideaux","year":"2011","journal-title":"Anal. Chem."},{"key":"2026092909103788000_cit14","doi-asserted-by":"publisher","first-page":"105225","DOI":"10.1016\/j.envexpbot.2023.105225","article-title":"Visualized\nAnalysis of Amino Acids and Organic Acids\nin Wheat Caryopsis in Response to Multigenerational Effects of Elevated\nAtmospheric CO2 Concentration","volume":"207","author":"Li","year":"2023","journal-title":"Environ. Exp.\nBot."},{"issue":"1","key":"2026092909103788000_cit15","doi-asserted-by":"publisher","first-page":"2166700","DOI":"10.1080\/19490976.2023.2166700","article-title":"Microbiome and Spatially Resolved\nMetabolomics Analysis Reveal the Anticancer Role of Gut Akkermansia\nMuciniphila by Crosstalk with Intratumoral Microbiota and Reprogramming\nTumoral Metabolism in Mice","volume":"15","author":"Zhu","year":"2023","journal-title":"Gut Microbes"},{"issue":"6","key":"2026092909103788000_cit16","doi-asserted-by":"publisher","first-page":"101057","DOI":"10.1016\/j.xcrm.2023.101057","article-title":"Integrated Spatial Transcriptome\nand Metabolism Study Reveals Metabolic\nHeterogeneity in Human Injured Brain","volume":"4","author":"Zheng","year":"2023","journal-title":"Cell Rep.\nMed."},{"issue":"1","key":"2026092909103788000_cit17","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1038\/s41467-023-38360-5","article-title":"Spatially\nResolved Multi-Omics Highlights Cell-Specific Metabolic Remodeling\nand Interactions in Gastric Cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat. Commun."},{"issue":"9","key":"2026092909103788000_cit18","doi-asserted-by":"publisher","DOI":"10.1002\/jms.4882","article-title":"DDA-Imaging with\nStructural Identification of Lipid Molecules on an Orbitrap Velos\npro Mass Spectrometer","volume":"57","author":"Khalil","year":"2022","journal-title":"J. Mass Spectrom."},{"issue":"22","key":"2026092909103788000_cit19","doi-asserted-by":"publisher","first-page":"9393","DOI":"10.1021\/ac102017q","article-title":"Imaging\nMS Methodology for More Chemical Information\nin Less Data Acquisition Time Utilizing a Hybrid Linear Ion Trap\u2013orbitrap\nMass Spectrometer","volume":"82","author":"Perdian","year":"2010","journal-title":"Anal. Chem."},{"issue":"1","key":"2026092909103788000_cit20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s13361-014-1013-x","article-title":"Comprehensive Lipidome Analysis by\nShotgun Lipidomics\non a Hybrid Quadrupole-Orbitrap-Linear Ion Trap Mass Spectrometer","volume":"26","author":"Almeida","year":"2015","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"7","key":"2026092909103788000_cit21","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/s41592-018-0010-6","article-title":"Automated,\nParallel Mass Spectrometry Imaging and Structural Identification of\nLipids","volume":"15","author":"Ellis","year":"2018","journal-title":"Nat. Methods"},{"issue":"12","key":"2026092909103788000_cit22","doi-asserted-by":"publisher","first-page":"5378","DOI":"10.1021\/acs.jproteome.5b00932","article-title":"Parallel Accumulation\u2013Serial\nFragmentation (PASEF): Multiplying Sequencing Speed and Sensitivity\nby Synchronized Scans in a Trapped Ion Mobility Device","volume":"14","author":"Meier","year":"2015","journal-title":"J. Proteome Res."},{"issue":"1","key":"2026092909103788000_cit23","doi-asserted-by":"publisher","first-page":"7495","DOI":"10.1038\/s41467-023-43298-9","article-title":"On-Tissue\nDataset-Dependent MALDI-TIMS-MS2 Bioimaging","volume":"14","author":"Heuckeroth","year":"2023","journal-title":"Nat. Commun."},{"issue":"13","key":"2026092909103788000_cit24","doi-asserted-by":"publisher","first-page":"6758","DOI":"10.1021\/acs.analchem.6b01060","article-title":"LESA FAIMS\nMass Spectrometry for the Spatial Profiling of Proteins from Tissue","volume":"88","author":"Griffiths","year":"2016","journal-title":"Anal. Chem."},{"issue":"14","key":"2026092909103788000_cit25","doi-asserted-by":"publisher","first-page":"7765","DOI":"10.1021\/acs.analchem.7b01782","article-title":"MALDI MS\nGuided Liquid Microjunction Extraction for Capillary Electrophoresis\u2013Electrospray\nIonization MS Analysis of Single Pancreatic Islet Cells","volume":"89","author":"Comi","year":"2017","journal-title":"Anal. Chem."},{"issue":"3","key":"2026092909103788000_cit26","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1021\/acs.jproteome.1c00641","article-title":"Multimodal Mass\nSpectrometry Imaging of Rat Brain Using IR-MALDESI and NanoPOTS-LC-MS\/MS","volume":"21","author":"Pace","year":"2022","journal-title":"J. Proteome Res."},{"issue":"22","key":"2026092909103788000_cit27","doi-asserted-by":"publisher","first-page":"11242","DOI":"10.1021\/acs.analchem.5b02115","article-title":"Pulsed Direct\nCurrent Electrospray:\nEnabling Systematic Analysis of Small Volume Sample by Boosting Sample\nEconomy","volume":"87","author":"Wei","year":"2015","journal-title":"Anal. Chem."},{"issue":"42","key":"2026092909103788000_cit28","doi-asserted-by":"publisher","first-page":"9907","DOI":"10.1002\/anie.201103687","article-title":"Induced\nNanoelectrospray Ionization for Matrix-Tolerant\nand High-Throughput Mass Spectrometry","volume":"50","author":"Huang","year":"2011","journal-title":"Angew.\nChem., Int. Ed."},{"issue":"23","key":"2026092909103788000_cit29","doi-asserted-by":"publisher","first-page":"6893","DOI":"10.1002\/anie.201501895","article-title":"On-Demand Ambient\nIonization of Picoliter Samples Using Charge Pulses","volume":"54","author":"Li","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026092909103788000_cit30","doi-asserted-by":"publisher","first-page":"128728","DOI":"10.1016\/j.talanta.2025.128728","article-title":"Automated Single-Cell\nAnalysis by Single-Cell Side-Orifice\nFlow Cytometry Chain Electrospray Ionization Mass Spectrometry","volume":"297","author":"Wang","year":"2026","journal-title":"Talanta"},{"key":"2026092909103788000_cit31","doi-asserted-by":"publisher","first-page":"126410","DOI":"10.1016\/j.talanta.2024.126410","article-title":"Chain Electrospray\nIonization Mass Spectrometry for Ultra-Low Volume Sample Analysis","volume":"277","author":"Wang","year":"2024","journal-title":"Talanta"},{"issue":"4","key":"2026092909103788000_cit32","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41592-019-0344-8","article-title":"SIRIUS 4:\nA Rapid Tool for Turning Tandem Mass Spectra into Metabolite Structure\nInformation","volume":"16","author":"Du\u0308hrkop","year":"2019","journal-title":"Nat. Methods"},{"issue":"19","key":"2026092909103788000_cit33","doi-asserted-by":"publisher","first-page":"10146","DOI":"10.1021\/acs.analchem.5b02998","article-title":"Mapping\nDrug Distribution in Brain\nTissue Using Liquid Extraction Surface Analysis Mass Spectrometry\nImaging","volume":"87","author":"Swales","year":"2015","journal-title":"Anal. Chem."},{"issue":"3","key":"2026092909103788000_cit34","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1021\/acs.analchem.2c04045","article-title":"Divide and Conquer: A Flexible Deep\nLearning Strategy for Exploring\nMetabolic Heterogeneity from Mass Spectrometry Imaging Data","volume":"95","author":"Guo","year":"2023","journal-title":"Anal. Chem."},{"issue":"42","key":"2026092909103788000_cit35","doi-asserted-by":"publisher","first-page":"14522","DOI":"10.1021\/acs.analchem.2c01456","article-title":"iSegMSI: An\nInteractive Strategy\nto Improve Spatial Segmentation of Mass Spectrometry Imaging Data","volume":"94","author":"Guo","year":"2022","journal-title":"Anal. Chem."},{"issue":"44","key":"2026092909103788000_cit36","doi-asserted-by":"publisher","first-page":"24697","DOI":"10.1021\/acs.analchem.5c04885","article-title":"MSInet: A Self-Supervised CNN Framework\nIntegrating Global and Local Context for Robust Mass Spectrometry\nImaging Segmentation","volume":"97","author":"Shah","year":"2025","journal-title":"Anal. Chem."},{"issue":"40","key":"2026092909103788000_cit37","doi-asserted-by":"publisher","first-page":"13927","DOI":"10.1021\/acs.analchem.2c02990","article-title":"Data-Driven Deciphering of Latent Lesions in Heterogeneous\nTissue Using Function-Directed t-SNE of Mass Spectrometry Imaging\nData","volume":"94","author":"Wang","year":"2022","journal-title":"Anal. Chem."},{"issue":"4","key":"2026092909103788000_cit38","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.cell.2020.04.007","article-title":"The Allen\nMouse Brain Common Coordinate Framework: A 3D Reference Atlas","volume":"181","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"2026092909103788000_cit39","first-page":"2673","article-title":"Review: Taurine: A \u201cVery Essential\u201d\nAmino Acid","volume":"18","author":"Ripps","year":"2012","journal-title":"Mol. Vis."},{"issue":"1","key":"2026092909103788000_cit40","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1152\/physrev.1992.72.1.101","article-title":"Physiological\nActions of Taurine","volume":"72","author":"Huxtable","year":"1992","journal-title":"Physiol. Rev."},{"issue":"S154","key":"2026092909103788000_cit41","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1600-0404.1994.tb05407.x","article-title":"Effects of Arginine,\nS-Adenosylmethionine and Polyamines\non Nerve Regeneration","volume":"89","author":"Cestaro","year":"1994","journal-title":"Acta Neurol. Scand."},{"issue":"1","key":"2026092909103788000_cit42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0898-6568(96)00089-7","article-title":"Modulation\nand Block of Ion Channels: A New Biology of Polyamines","volume":"9","author":"Williams","year":"1997","journal-title":"Cell. Signalling"},{"issue":"1","key":"2026092909103788000_cit43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/tra.12230","article-title":"Phospholipid\nSynthesis and Transport in Mammalian Cells","volume":"16","author":"Vance","year":"2015","journal-title":"Traffic"},{"key":"2026092909103788000_cit44","article-title":"Corpus Callosum","volume-title":"StatPearls","author":"Goldstein","year":"2026"},{"issue":"1","key":"2026092909103788000_cit45","doi-asserted-by":"publisher","first-page":"100360","DOI":"10.1016\/j.xinn.2022.100360","article-title":"Myelin Lipid Metabolism and Its Role\nin Myelination and Myelin Maintenance","volume":"4","author":"Barnes-Ve\u0301lez","year":"2023","journal-title":"Innovation"},{"issue":"18","key":"2026092909103788000_cit46","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1002\/1873-3468.12788","article-title":"From Peroxisomal Disorders to Common\nNeurodegenerative Diseases \u2013 the Role of Ether Phospholipids\nin the Nervous System","volume":"591","author":"Dorninger","year":"2017","journal-title":"FEBS Lett."},{"issue":"2","key":"2026092909103788000_cit47","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s13238-017-0423-5","article-title":"Structural and Functional\nRoles of Ether Lipids","volume":"9","author":"Dean","year":"2018","journal-title":"Protein Cell"},{"issue":"1","key":"2026092909103788000_cit48","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nmeth.4512","article-title":"Identifying Metabolites\nby Integrating Metabolome Databases with\nMass Spectrometry Cheminformatics","volume":"15","author":"Lai","year":"2018","journal-title":"Nat. Methods"}],"container-title":["Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.6c02449","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/38\/28006\/68539377\/acs.analchem.6c02449.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancham\/article-pdf\/98\/38\/28006\/68539377\/acs.analchem.6c02449.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:27:35Z","timestamp":1790688455000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancham\/article\/98\/38\/28006\/5431754\/InSitu-Untargeted-Metabolite-Identification-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":48,"journal-issue":{"issue":"38","published-online":{"date-parts":[[2026,9,17]]},"published-print":{"date-parts":[[2026,9,29]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.analchem.6c02449","relation":{},"ISSN":["0003-2700","1520-6882"],"issn-type":[{"value":"0003-2700","type":"print"},{"value":"1520-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]}}}