{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:08:44Z","timestamp":1788872924793,"version":"build-2803163510"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interactions between plastic nanoparticles (PNPs) or nanoplastics and lipid membranes are governed by a coupled interplay of membrane composition and ionic environment, yet how lipid unsaturation and ion specificity regulate PNP diffusion remains poorly understood. Here, we investigate the effects of acyl-chain saturation and Hofmeister cations on the interactions of carboxylated polystyrene (PS) nanoparticles with phosphatidylcholine membranes composed of dipalmitoylphosphatidylcholine (DPPC), palmitoyloleoylphosphatidylcholine (POPC), and dioleoylphosphatidylcholine (DOPC) lipids. Langmuir isotherms show that lipid packing decreases with increasing unsaturation and that divalent cations, particularly Ca2+, induce pronounced membrane condensation across all lipid types, while monovalent cations produce weaker effects. To relate membrane structure to nanoparticle diffusion, we combine single-particle tracking (SPT) with fluorescence correlation spectroscopy super-resolution optical fluctuation imaging (fcsSOFI) as an analytical method to quantify nanoparticle confinement and diffusion on supported lipid bilayers. Salt addition modulates diffusion and confinement independently, in a manner that depends strongly on lipid identity. On POPC, confinement follows a divalent\/monovalent distinction consistent with the Hofmeister series, while diffusion remains unchanged. On DPPC, diffusion is reduced by all salts without systematic confinement changes. On DOPC, both properties are largely insensitive to ion identity. These results show that nanoplastic dynamics at membrane interfaces cannot be predicted from membrane fluidity alone and are governed by the interplay between membrane phase state, mechanical compliance, and ion-specific headgroup interactions.<\/jats:p>","DOI":"10.1021\/acs.analchem.6c02646","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:27:47Z","timestamp":1788247667000},"page":"25711-25720","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Membrane\nFluidity: Lipid Unsaturation and Hofmeister\nCations Govern Nanoplastic Dynamics at Membrane Interfaces"],"prefix":"10.1021","volume":"98","author":[{"given":"Cristina","family":"Lopez-Galicia","sequence":"first","affiliation":[{"name":"Georgia State University , , , ,","place":["Atlanta, Georgia, United States, 30303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diyali","family":"Sil","sequence":"additional","affiliation":[{"name":"Georgia State University , , , ,","place":["Atlanta, Georgia, United States, 30303"]},{"name":"Georgia State University , , , ,","place":["Atlanta, Georgia, United States, 30303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhane","family":"Norris","sequence":"additional","affiliation":[{"name":"Georgia State University , , , ,","place":["Atlanta, Georgia, United States, 30303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4839-2245","authenticated-orcid":true,"given":"Chayan","family":"Dutta","sequence":"additional","affiliation":[{"name":"Georgia State University , , , ,","place":["Atlanta, Georgia, United States, 30303"]},{"name":"Georgia State University , , , ,","place":["Atlanta, Georgia, United States, 30303"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"issue":"1","key":"2026090808080953000_cit1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/cphc.201900481","article-title":"Can nanoplastics alter cell membranes?","volume":"21","author":"Hollo\u0301czki","year":"2020","journal-title":"ChemPhysChem"},{"issue":"1","key":"2026090808080953000_cit2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12951-022-01321-z","article-title":"Distinct\nlipid membrane interaction and uptake of differentially charged nanoplastics\nin bacteria","volume":"20","author":"Dai","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"22","key":"2026090808080953000_cit3","doi-asserted-by":"publisher","first-page":"8846","DOI":"10.1021\/acs.analchem.3c05948","article-title":"Challenges and Recent\nAnalytical Advances in Micro\/Nanoplastic Detection","volume":"96","author":"Choi","year":"2024","journal-title":"Anal. Chem."},{"issue":"1","key":"2026090808080953000_cit4","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1039\/D5EN00599J","article-title":"Engineering\nplastic nanoparticles for super-resolution tracking of lipid membrane\ninteractions","volume":"13","author":"Osmanbasic","year":"2026","journal-title":"Environ. Sci.: Nano"},{"issue":"20","key":"2026090808080953000_cit5","doi-asserted-by":"publisher","first-page":"5428","DOI":"10.1021\/acs.jpclett.4c00806","article-title":"Variable Non-Gaussian\nTransport of Nanoplastic on Supported Lipid Bilayers in Saline Conditions","volume":"15","author":"Sil","year":"2024","journal-title":"J. Phys. Chem. Lett."},{"issue":"12","key":"2026090808080953000_cit6","doi-asserted-by":"publisher","first-page":"11541","DOI":"10.1021\/acsnano.6b07563","article-title":"Diffusion and Directionality\nof Charged\nNanoparticles on Lipid Bilayer Membrane","volume":"10","author":"Chen","year":"2016","journal-title":"ACS\nNano"},{"issue":"3","key":"2026090808080953000_cit7","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1021\/nl080080l","article-title":"Interaction of nanoparticles with\nlipid membrane","volume":"8","author":"Roiter","year":"2008","journal-title":"Nano Lett."},{"issue":"49","key":"2026090808080953000_cit8","doi-asserted-by":"publisher","first-page":"12378","DOI":"10.1021\/jp010118h","article-title":"Effect of unsaturated\nlipid chains on dimensions, molecular\norder and hydration of membranes","volume":"105","author":"Binder","year":"2001","journal-title":"J. Phys. 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Phys."},{"issue":"28","key":"2026090808080953000_cit32","doi-asserted-by":"publisher","first-page":"8391","DOI":"10.1021\/la5012007","article-title":"Charge-Dependent\nTransport Switching of Single Molecular Ions in a Weak Polyelectrolyte\nMultilayer","volume":"30","author":"Tauzin","year":"2014","journal-title":"Langmuir"},{"issue":"25","key":"2026090808080953000_cit33","doi-asserted-by":"publisher","first-page":"256101","DOI":"10.1103\/PhysRevLett.110.256101","article-title":"Intermittent\nmolecular hopping at\nthe solid-liquid interface","volume":"110","author":"Skaug","year":"2013","journal-title":"Phys. Rev. Lett."},{"issue":"10","key":"2026090808080953000_cit34","doi-asserted-by":"publisher","first-page":"101101","DOI":"10.1063\/5.0139719","article-title":"Single-molecule tracking\nof dye diffusion in synthetic\npolymers: A tutorial review","volume":"133","author":"Tran-Ba","year":"2023","journal-title":"J. Appl. 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Chem.\nLett."},{"key":"2026090808080953000_cit38","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.colsurfa.2011.12.059","article-title":"DPPC\u2013DOPC\nLangmuir monolayers modified by hydrophilic silica nanoparticles:\nPhase behaviour, structure and rheology","volume":"413","author":"Guzma\u0301n","year":"2012","journal-title":"Colloids\nSurf., A"},{"issue":"44","key":"2026090808080953000_cit39","doi-asserted-by":"publisher","first-page":"14188","DOI":"10.1021\/acs.jpcb.5b08985","article-title":"Oxidative degradation of the monolayer\nof 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) in low-level\nozone","volume":"119","author":"Qiao","year":"2015","journal-title":"J. Phys. Chem. 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Acta, Biomembr."},{"issue":"3","key":"2026090808080953000_cit45","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0304-4157(96)00009-3","article-title":"Lateral pressure\nin membranes","volume":"1286","author":"Marsh","year":"1996","journal-title":"Biochim. Biophys. Acta Rev. Biomembr."},{"issue":"1","key":"2026090808080953000_cit46","doi-asserted-by":"publisher","first-page":"3654237","DOI":"10.1155\/2017\/3654237","article-title":"Molecular\nDynamics of POPC Phospholipid Bilayers through the Gel to Fluid Phase\nTransition: An Incoherent Quasi-Elastic Neutron Scattering Study","volume":"2017","author":"Wanderlingh","year":"2017","journal-title":"J. Chem."},{"issue":"1","key":"2026090808080953000_cit47","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0005-2736(94)90253-4","article-title":"Hydration\nof DOPC bilayers by differential\nscanning calorimetry","volume":"1191","author":"Ulrich","year":"1994","journal-title":"Biochim. Biophys. 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Acta, Biomembr."},{"key":"2026090808080953000_cit51","doi-asserted-by":"publisher","DOI":"10.1101\/2025.10.11.681803","article-title":"Lipid\ntail chemistry regulates selective membrane interactions with DNA\nnanoprobes and DNA-based coacervates","author":"Li","year":"2025","journal-title":"bioRxiv"},{"issue":"6","key":"2026090808080953000_cit52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2518553123","article-title":"Hydration gradients\ndrive lipid self-segregation","volume":"123","author":"Labecka","year":"2026","journal-title":"Proc. Natl. Acad.\nSci. U. S. 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